New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. In an article, author is Lukowska-Chojnacka, Edyta, once mentioned the application of 392-56-3, Category: benzoxazole, Name is Hexafluorobenzene, molecular formula is C6F6, molecular weight is 186.0546, category is benzoxazole. Now introduce a scientific discovery about this category.
Novel benzoxazole derivatives were synthesized, and their antitubercular activity against sensitive and drug-resistant Mycobacterium tuberculosis strains (M.tuberculosis H(37)Rv, M.tuberculosis sp. 210, M.tuberculosis sp. 192, Mycobacterium scrofulaceum, Mycobacterium intracellulare, Mycobacterium fortuitum, Mycobacterium avium, and Mycobacterium kansasii) was evaluated. The chemical step included preparation of ketones, alcohols, and esters bearing benzoxazole moiety. All racemic mixtures of alcohols and esters were separated in Novozyme SP 435-catalyzed transesterification and hydrolysis, respectively. The transesterification reactions were carried out in various organic solvents (tert-butyl methyl ether, toluene, diethyl ether, and diisopropyl ether), and depending on the solvent, the enantioselectivity of the reactions ranged from 4 to >100. The enzymatic hydrolysis of esters was performed in 2 phase tert-butyl methyl ether/phosphate buffer (pH=7.2) system and provided also enantiomerically enriched products (ee 88-99%). The antitubercular activity assay has shown that synthesized compounds exhibit an interesting antitubercular activity. Racemic mixtures of alcohols, (+/-)-4-(1,3-benzoxazol-2-ylsulfanyl)butan-2-ol ((+/-)-3a), (+/-)-4-[(5-bromo-1,3-benzoxazol-2-yl)sulfanyl]butan-2-ol ((+/-)-3b), and (+/-)-4-[(5,7-dibromo-1,3-benzoxazol-2-yl)sulfanyl]butan-2-ol ((+/-)-3c), displayed as high activity against M.scrofulaceum, M.intracellulare, M.fortuitum, and M.kansasii as commercially available antituberculosis drug-Isoniazid. Moreover, these compounds exhibited twice higher activity toward M.avium (MIC 12.5) compared with Isoniazid (MIC 50).
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 392-56-3 is helpful to your research. Category: benzoxazole.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem