392-56-3, molecular formula is C6F6, molweight is 186.0546(g/mol), MDLNum is MFCD00000288. In this document, Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory. Product Details of 392-56-3.
Based on the Gaussian-based quantitative structure-activity relationship (QSAR) and virtual screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEls) having antioxidant potential were designed synthesized, characterized, and evaluated for their ability to enhance learning and memory. The synthesized phenyl benzoxazole derivatives exhibited significant antioxidant potential and AChE inhibitory activity, whereas the antioxidant potential of compound 34 (49.6%) was observed significantly better than standard donepezil (<10%) and parallel to ascorbic acid (56.6%). Enzyme kinetics study of most potent compound 34 (AChE IC50 = 0.363 +/- 0.017 mu M; Ki = 0.19 +/- 0.03 mu M) revealed the true nature and competitive type of inhibition on AChE. The compound 34 was further assessed for in vivo and ex vivo studies and the results showed the significant reversal of cognitive deficits and antioxidant potential at the dose of 5 mg/kg comparable to standard drug donepezil. (C) 2018 Elsevier Masson SAS. All rights reserved. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 392-56-3 help many people in the next few years. Product Details of 392-56-3.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem