Why do aromatic interactions matter? In this blog, let’s explore why it’s so important to understand aromatic interactions using C12H7Br2N as examples. Computed Properties of https://www.ambeed.com/products/6825-20-3.html
An efficient Palladium/Copper bimetallic co-catalyzed direct 2-arylation of benzoxazoles with aryl chlorides is presented. The Pd(OAc)(2)/Cul/NiXantphos-based catalyst enables the installation of various aryl and heteroaryl groups in good to excellent yields (75-99%). Preliminary mechanism investigation indicates that Pd/Nixantphos complex activates C-Cl bond of aryl chlorides via oxidative addition, and Cu/Nixantphos complex chelates with nitrogen atom to lower the pK(a) of the 2-H in benzoxazoles. (C) 2019 Elsevier Ltd. All rights reserved.
Computed Properties of https://www.ambeed.com/products/6825-20-3.html, This is part of our series highlighting examples of C12H7Br2N in action by scientists around the world.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem