Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.132244-31-6,5-Bromobenzo[d]oxazole,as a common compound, the synthetic route is as follows.

Benzoxazole (1.0 mmol), N,N-disubstituted formamide (15 mmol), TBAI (0.2 equiv/74 mg), TBHP (70% aqueous solution, 10 mmol/1.37 mL), and acetic acid (5.0 equiv) in 1,2-dichloroethane (3.0 mL) were added to a reaction vessel in air. The reaction mixture was heated in an oil bath at 90 C for 12 h. After completion of the reaction, the mixture was quenched by addition of a saturated solution of sodium disulfite (4.0 mL, for removal of excess TBHP) and a saturated solution of sodium hydrogen carbonate (4.0 mL). Then the mixture was extracted with ethyl acetate (3 ¡Á 15 mL), combined organic phases were dried over anhydrous Na2SO4 and the organic solvent was removed under vacuum. The crude residue was purified by chromatography on a silica gel column affording the desired product.

132244-31-6, The synthetic route of 132244-31-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Rui; Liu, Hong; Yue, Liang; Zhang, Xiao-Ke; Tan, Qiu-Yuan; Pan, Ruo-Lin; Tetrahedron Letters; vol. 55; 14; (2014); p. 2233 – 2237;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

2382-96-9, Benzo[d]oxazole-2-thiol is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of thiol (1 mmol), H2O2 (0.4 mL) and catalyst(0.01 g) was stirred in ethanol at room temperature for thecertain period of time. The reaction was monitored byTLC. After completion of the reaction, the catalyst wasseparated by simple filtration and the mixture was washedwith CH2Cl2 (5 9 2 mL), and next, the product wasextracted with CH2Cl2 (5 mL 9 4). The organic layer wasdried over anhydrous Na2SO4 (1.5 g). After the evaporationof dicoloromethan gave the pure products in 85-98 %yields., 2382-96-9

2382-96-9 Benzo[d]oxazole-2-thiol 712377, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Article; Hajjami, Maryam; Yousofvand, Zakieh; Catalysis Letters; vol. 145; 9; (2015); p. 1733 – 1740;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2382-96-9,Benzo[d]oxazole-2-thiol,as a common compound, the synthetic route is as follows.

[00318] To a DMF (5 ml) solution of this amide (90 mg, 0.25 mmol) and 2-mercaptobenzoxazole (38 mg, 0.25 mmol) were added potassium carbonate (42 mg, 0.30 mmol) and 18-crown-6 (7 mg, 0.03 mmol), and the mixture was stirred at 80 C. for 3 hours. The reaction mixture was allowed to cool, and then extracted with ethyl acetate. The organic layer was washed with water and then with a saturated aqueous solution of sodium chloride, and dried over sodium sulfate. Subsequently, the solvent was distilled off, and the resulting residue was recrystallized from a mixture of ethyl acetate-hexane to obtain 83 mg (yield 77%) of the desired compound as a colorless powdery crystal. [00319] Melting point: 84-85 C. [00320] IR (KBr) cm-1: 3465, 3276, 2926, 1664, 1505. [00321] 1H-NMR (CDCl3) delta: 1.35-1.53 (8H, m), 1.72-1.77 (2H, m), 1.80-1.87 (2H, m), 2.42 (2H, t, J=7.3 Hz). 2.63 (3H, s), 3.31 (2H, t, J=7.4 Hz), 7.06 (1H, dd, J=8.0, 4.7 Hz), 7.21-7.30 (3H, m), 7.43 (1H, dd, J=7.0, 0.6 Hz), 7.59 (1H, dd, J=7.6, 0.6 Hz), 8.25 (1H, d, J=4.7 Hz), 8.31 (1H, d, J=7.8 Hz). [00322] EIMS m/z (relative intensity): 429 (M+), 297 (100). [00323] Elemental analysis: as C22H27N3O2S2; calculated: C, 61.51; H, 6.33; N, 9.78; S, 14.93. found: C, 61.51; H, 6.28; N, 9.64; S, 14.99.

2382-96-9, The synthetic route of 2382-96-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kowa Company, Ltd.; US6849647; (2005); B1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

864274-04-4, 2-Methylbenzo[d]oxazole-6-carbaldehyde is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

864274-04-4, To a solution of compound 66 (50 mg, 174.6 imo1, 1 eq) in 1 mL of MeOH was added 2-methyl-1,3-benzoxazole-6-carbaldehyde (30.9 mg, 192.1 imol, 1.1 eq) and HOAc (1.1 mg,17.5 imol, 0.1 eq). The mixture was stirred for 0.5 hour at 25¡ãC. Then NaBH3CN (16.5 mg, 261.9 imol, 1.5 eq) was added and the mixture was stirred for 11.5 hours. The reaction mixture was filtered and the filtrate was purified by prep-HPLC (neutral condition) to get 30.9 mg ofcompound 530 (40.6percent yield, 99.1percent purity) as a white solid.?H NMR (400MHz, CHLOROFORM-cl) oe ppm 11.34 – 11.21 (m, 1H), 7.77 – 7.70 (m, 1H),7.53-7.48 (m, 2H), 7.42 (d,J=5.5 Hz, 1H), 7.27 (brs, 2H), 7.21- 7.19(m, 1H), 5.91 -5.85 (m,1H), 4.54 (br t, J=11.9 Hz, 1H), 4.24 (q, J=6.9 Hz, 1H), 3.91 – 3.89 (m, 2H), 3.55 (q, J7.0 Hz,1H), 2.79-2.76 (m, 1H), 2.57 (s, 3H), 2.31 -2.11 (m, 1H), 1.97- 1.82 (m, 3H), 1.54- 1.47 (m,3H), 1.29 (t, J=7.0 Hz, 3H), 1.27 – 1.09 (m, 1H).LCMS (ESI+): m/z 432.2 (M+H)

The synthetic route of 864274-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4570-41-6,Benzo[d]oxazol-2-amine,as a common compound, the synthetic route is as follows.,4570-41-6

The Schiff base, N-((thiophen-2-yl)methyleneimino)benzoxazole (Htbi) was isolated as an orange crystalline substance from the equimolar condensation reaction between 2-aminobenzoxazole (0.250 g; 1.86 mmol) and 2-thiophenecarboxaldehyde (0.209; 1.86 mmol). The reaction was conducted in 40 cm3 of dry toluene and in the presence 3 drops of piperidine, under nitrogen for 6 hours followed by reducing the reaction mixture to 5 cm3 and cooling it in an ice-bath to induce crystallization. The reducing agent, sodium borohydride (0.025 g, 0.66 mmol) in ethanol ethanol (10 cm3) was added dropwise to a stirring solution of ethanol (20 cm3) containing 0.15 g of Htbi (0.66 mmol) at room temperature. The reaction mixture was then refluxed for an hour and thereafter cooled to room temperature by adding an equal volume of cold distilled water. A white precipitate instantaneously formed which was collected, washed with distilled water and dried under vacuum. Yield = 88percent,

4570-41-6 Benzo[d]oxazol-2-amine 20707, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Article; Booysen, Irvin Noel; Adebisi, Abimbola; Akerman, Matthew Piers; Inorganica Chimica Acta; vol. 433; (2015); p. 13 – 20;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.132244-31-6,5-Bromobenzo[d]oxazole,as a common compound, the synthetic route is as follows.

A solution of [5-FORMYL-2-METHOXYBENZENEBORONIC] acid (1 g, 5.6 mmol), 2- methyl-5-bromobenzoxazole (1 g, 4.72 mmol) and [K2CO3] (1.63 g, 11.8 mmol) in ethanol (20 mL) and toluene (40 mL) was degassed prior to addition of Pd [(PH3)] 4 (55 mg, 0.047 mmol). The mixture was refluxed for 20 hours then cooled and filtered through diatomaceous earth. The filtrate was concentrated in vacuo, extracted with ethyl acetate, washed with water and the organic layer dried over sodium sulphate. The crude was purified by column chromatography (heptane/ethyl acetate 7/3 to [6/4)] to give 1.13 g of title compound. [CL5HLLNO3] Mass (calculated): [253]; (found): [[M+H+]] : 254,295. [NMR (400 MHZ, CDC13) : 2.6 (3H, S, CH3) ; 3.95 (3H, S, CH30) ; 7.15 (1H, D, , J = 8 HZ, ARYL-H); 7.55 (1H, D, , J = 8 HZ, ARYL-H); 7.65 (1H, D, , J = 8 HZ, ARYL-H);] 7.85-7. 95 (2H, aryl-H); 8 [(1H,] s, aryl-H); 8.15 [(1H,] s, aryl-H); 10.0 [(1H,] s, CHO)., 132244-31-6

132244-31-6 5-Bromobenzo[d]oxazole 21749504, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN INC.; WO2003/99776; (2003); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

90322-32-0, 2-Methylbenzo[d]oxazole-5-carboxylic acid is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90322-32-0

Following general procedure B, Compound (i?-32 was prepared from compound B-129 (69 mg, 0.39 mmol) and compound (i?)-A-104 (50 mg, 0.32 mmol), with a reaction time of 12 hours. The product was purified by prep-HPLC [Instrument: GX-C; Column: Phenomenex Gemini CI 8 150×30 mm, particle size: 5 mupiiota; Mobile phase: 35-65percent acetonitrile in H20 (add 0.5percent NH3 H20, v/v)] to give: (R)-N-(2,2 -dimethylquinuclidin-3 -yl) -2-methylbenzo [d] oxazole -5 -carboxamide (compound (i?)-32) (30 mg, 30percent yield) as a white solid: cSFC analytical (A) tR=2.44 min., purity: 96.08percent; LCMS (J): tR=0.995 min., 314.1 m/z (M+1); -NMR (CD3OD, 400 MHz): delta 8.10 (s, IH), 7.87-7.85 (m, IH), 7.67 (d, J=8.8 Hz, IH), 4.07 (s, IH), 3.33-3.33 (m, 2H), 2.85-2.85 (m, 2H), 2.69 (s, 3H), 2.09-2.09 (m, IH), 1.97-1.86 (m, 3H), 1.67-1.64 (m, IH), 1.51 (s, 3H), 1.32 (s, 3H).

90322-32-0 2-Methylbenzo[d]oxazole-5-carboxylic acid 23282284, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; KOENIG, Gerhard; MCRINER, Andrew, J.; (400 pag.)WO2016/100184; (2016); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59-49-4,2-Benzoxazolinone,as a common compound, the synthetic route is as follows.

2j: 3-(3-Chloro-propyl)-3H-benzoxazol-2-one Sodium hydride (60% in oil dispersion) (155 mmol) was washed with diethyl ether under an argon atmosphere, then suspended in DMF (75 mL). 3H-Benzoxazol-2-one (148 mmol) was dissolved in DMF (150 mL) and added drop wise to the slurry. After stirring for ca. 30 min. the mixture was homogenous and was then cooled to -5 C on an acetone-ice bath. 1-Bromo- 3-chloropropane (296 mmol) was dissolved in DMF (50 mL) and added drop wise to the cold solution. The reaction mixture was allowed to come to room temperature and stirring was continued for 18h. Poured into H2O, the aqueous phase was extracted x3 with ethyl acetate.The combined organic fractions were washed x2 with NH4Cl (aq., sat.) dried on MgSO4 and the solvent was removed by evaporation to yield an oil which solidified on standing. The obtained solid was washed with diethyl ether and dried in vacuo. The product was udes without further purification.Yield = 54%1H NMR (D6-DMSO): 2.16 (qui, 2H); 3.71 (t, 2H); 3.96 (t, 2H); 7.14 (t, IH); 7.24 (t, IH);7.29-7.36 (2H)., 59-49-4

The synthetic route of 59-49-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; H. LUNDBECK A/S; WO2009/106534; (2009); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59-49-4,2-Benzoxazolinone,as a common compound, the synthetic route is as follows.

To a mixture of 3H-benzooxazol-2-one (20 g, 0.15 mol) in DCM (500 mL) was added bromine (8.34 mL, 0.16 mol). After stirring at room temperature for 19.5 h, the orange precipitate that had formed was filtered off and washed with DCM until the orange color was washed out. The filtrate was concentrated to approximately 33% of its original volume and filtered and washed as before. The combined solids weighed 28.36 g and contained ca. 8-9% starting material., 59-49-4

59-49-4 2-Benzoxazolinone 6043, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/86705; (2006); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

The benzoxazole compound, cas is 2382-96-9 name is Benzo[d]oxazole-2-thiol, mainly used in chemical industry, its synthesis route is as follows.,2382-96-9

General procedure: In a typical procedure, a solution of thiol (1 mmol) and Fe3O4/AMPD/Ni (0.005 g) was added to a round-bottomed flask containing H2O2 (0.5 mL) and 2 mL of ethanol and stirred at room temperature for an appropriate time. After completion of the addition, Fe3O4/AMPD/Ni catalyst was easily separated by a simple magnet, and then the product was extracted with ethyl acetate and dried over anhydrous Na2SO4 to give the pure disulfides.

As the rapid development of chemical substances, we look forward to future research findings about 2382-96-9

Reference£º
Article; Tamoradi, Taiebeh; Mehraban-Esfandiari, Bita; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash; Research on Chemical Intermediates; vol. 44; 2; (2018); p. 1363 – 1380;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem