Application of Tris[2-(dimethylamino)ethyl]amine

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The benzoxazole compound, cas is 59-49-4 name is 2-Benzoxazolinone, mainly used in chemical industry, its synthesis route is as follows.,59-49-4

Example 251A 6-bromo-1,3-benzoxazol-2(3H)-one A mixture of 2-benzoxazolinone (3.00 g, 22.2 mmol), 1,3-dibromo-5,5-dimethylhydantoin (3.49 g, 12.2 mmol), and trifluoromethanesulfonic acid (5.00 g, 33.3 mmol) in dichloromethane (100 mL) at room temperature was protected from light, stirred for 1 hour, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product.

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Reference£º
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/86887; (2002); A1;,
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Downstream synthetic route of 2382-96-9

The synthetic route of 2382-96-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2382-96-9,Benzo[d]oxazole-2-thiol,as a common compound, the synthetic route is as follows.

General procedure: In a typical procedure, a solution of thiol (1 mmol) and Fe3O4/AMPD/Ni (0.005 g) was added to a round-bottomed flask containing H2O2 (0.5 mL) and 2 mL of ethanol and stirred at room temperature for an appropriate time. After completion of the addition, Fe3O4/AMPD/Ni catalyst was easily separated by a simple magnet, and then the product was extracted with ethyl acetate and dried over anhydrous Na2SO4 to give the pure disulfides., 2382-96-9

The synthetic route of 2382-96-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tamoradi, Taiebeh; Mehraban-Esfandiari, Bita; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash; Research on Chemical Intermediates; vol. 44; 2; (2018); p. 1363 – 1380;,
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Introduction of a new synthetic route about 59-49-4

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2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4

40.0 g (0.30 mol) of 2-benzoxazolinone were dissolved with stirring at room temperature in 600.0 ml (0.30 mole) of 68% nitric acid. It was then heated to 50 C. and stirred at this temperature for three hours. The reaction was stirred for a further 16 h at room temperature. After completion of the reaction, the mixture was poured into about 2.0 l of ice water, precipitated substance was filtered off, washed neutral and dried. After drying, 6-nitro-3H-1,3-benzoxazol-2-one (39.1 g, 72%) was obtained as a pale yellow solid. 1H-NMR (300 MHz, d6-DMSO): delta=7.25 (d, 1H, 4-H), 8.10 (d, 1H, 5-H), 8.17 (s, 1H, 7-H), 12.43 (br s, 1H, NH).

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Reference£º
Patent; Henkel AG & Co. KGaA; Gebert-Schwarzwaelder, Antje; Nemitz, Ralph; Kroos, Astrid; Koenen, Annika; (20 pag.)US2019/167551; (2019); A1;,
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Some tips on 2382-96-9

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2382-96-9, Benzo[d]oxazole-2-thiol is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To an oven dried flask equipped with a stir bar cooled under argon was added benzo[d]oxazole- 2(3H)-thione (0.375 grams, 2.48 mmol) and K2C03 (1.37, 9.92 mmol). The was taken up in 20.0 mL anhydrous acetone. After stirring for approximately minutes at room temperature, methyl iodide (0.25 mL, 3.97 mmol) was added. The solution continued to stir at room temperature overnight. The next day the solution was filtered through a plug of celite, and rinsed with dichloromethane and ethyl acetate. The solution was then concentrated. It was then taken up in ethyl acetate, filtered, and concentrated again. It was then used without further purification. Calculated mass for Chemical Formula: C8H7NOS Exact Mass: 165.02 observed 166.1 (M+l, MM API/ESI)., 2382-96-9

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Reference£º
Patent; MUSC FOUNDATION FOR RESEARCH DEVELOPMENT; U.S. DEPARTMENT OF VETERANS AFFAIRS; LINDSEY, Christopher, C.; BEESON, Craig, C.; SCHNELLMANN, Rick, G.; (51 pag.)WO2018/85491; (2018); A1;,
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Introduction of a new synthetic route about 2382-96-9

With the rapid development of chemical substances, we look forward to future research findings about 2382-96-9

Benzo[d]oxazole-2-thiol, cas is 2382-96-9, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,2382-96-9

General procedure: A mixture of thiols (1 mmol), UHP (5 mmol), and Co orFeMCM-41 (20 mg) was stirred at room temperature inethanol and the progress of the reaction was monitored by TLC.After completion of the reaction, the catalyst was removed andthe products were extracted with CH2Cl2 (3 ¡Á 10 mL). Theresults are shown in Table 7.

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Article; Noori, Nourolah; Nikoorazm, Mohsen; Ghorbani-Choghamarani, Arash; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 10; (2016); p. 1388 – 1395;,
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Introduction of a new synthetic route about 59-49-4

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4

The reaction mixture was purified directly by silica gel column chromatography (ethyl acetate: hexane =1:1) to obtain a pale red solid product. Yield 108 mg (99%).

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Reference£º
Patent; Kyushu University, National University Corporation; OHSHIMA Takashi; MORIMOTO Hiroyuki; SHIMIZU Yuhei; EP2821389; (2015); A1;,
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Downstream synthetic route of 2382-96-9

The synthetic route of 2382-96-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2382-96-9,Benzo[d]oxazole-2-thiol,as a common compound, the synthetic route is as follows.

Specifically include:Solid phosgene (BTC) is selected as the chlorinating agent.2 mmol of 2-mercaptobenzoxazole prepared in the step 1 was added to the flask.Add 10 mL of toluene or cyclohexane as solvent to the flask.4 mmol of solid triphosgene was added to the flask.Warm up to 50 C under magnetic stirring, keep warm for 10 min, and then slowly heat up.Each temperature is raised at 10 C for 10 min, when the temperature is raised to 105 C, the temperature is kept for 1 h; TCL point plate analysis,Properly extend the reaction time,After separation by column chromatography, 0.142 g of 2-chlorobenzoxazole was obtained.The product was slightly yellowish liquid with a yield of 46%., 2382-96-9

The synthetic route of 2382-96-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chen Wantong; (5 pag.)CN108794421; (2018); A;,
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Introduction of a new synthetic route about 59-49-4

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4

To a mixture of 3H-benzooxazol-2-one (20 g, 0.15 mol) in DCM (500 mL) was added bromine (8.34 mL, 0.16 mol). After stirring at room temperature for 19.5 h, the orange precipitate that had formed was filtered off and washed with DCM until the orange color was washed out. The filtrate was concentrated to approximately 33% of its original volume and filtered and washed as before. The combined solids weighed 28.36 g and contained ca. 8-9% starting material.

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Reference£º
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/86705; (2006); A1;,
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Simple exploration of 59-49-4

As the paragraph descriping shows that 59-49-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59-49-4,2-Benzoxazolinone,as a common compound, the synthetic route is as follows.

Ar gas protection, Ice bath conditions, NaH (910 mg, 47.9 mmol) was added to dry THF and benzoxetine was added (3.6 g, 26.6 mmol) Dissolved in anhydrous THF, Methyl iodide (5.7 g, 40 mmol) was slowly added, Reaction to ice bath to room temperature overnight reaction. After the reaction was stopped, the mixture was concentrated, diluted with water, extracted with DCM, dried and separated on a light reddish brown solid (2.8 g, 71%), 59-49-4

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Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Shen Zhufang; Bie Jianbo; Mu Yongzhao; Chen Hualong; Liu Lvnan; Zhou Jie; Li Caina; Cao Ran; Huan Yi; Sun Shujuan; (258 pag.)CN107098846; (2017); A;,
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Introduction of a new synthetic route about 2382-96-9

With the rapid development of chemical substances, we look forward to future research findings about 2382-96-9

Benzo[d]oxazole-2-thiol, cas is 2382-96-9, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,2382-96-9

General procedure: For the fabrication of sulfoxide, 1 mmol sulfide, 0.6 ml H2O2 (33%) and 0.005 g nanocatalyst were stirred at room temperature. Also, for producing disulfides, 1 mmol thiols and 0.4 ml H2O2 (33%) with 0.008 g nanocatalyst in ethanol as a green solvent were mixed at 25 C. After completion of the reaction, the catalyst was removed by a magnet and the product was extracted with ethyl acetate and dried using a vacuum dryer.

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Reference£º
Article; Moeini, Nazanin; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash; Polyhedron; vol. 170; (2019); p. 278 – 286;,
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