Day: September 27, 2020

5676-60-8, 2-Methylbenzo[d]oxazol-6-amine is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5676-60-8

General procedure: To a solution of compound 3 (3.37 mmol) in DMF (10 mL), charged respective compound V (a-p) (4.04 mmol) and heated to 80 C. After3 h, TLC analysis showed complete conversion of starting materials. The reaction mixture was cooled to room temperature, charged water (30 mL) and extracted with EtOAc (2 ¡Á 20 mL). The combined organic layer was washed with water (20 mL) followed by brine and concentrated under reduced pressure to obtain gummy liquid. This crude material was triturated with MTBE to afford desired product as solid and which used as such in next step without any further purification.

The synthetic route of 5676-60-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Balraju, Vadla; Jogula, Sridhar; Krishna, Vagolu Siva; Meda, Nikhila; Sriram, Dharmarajan; Bioorganic Chemistry; vol. 100; (2020);,
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2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4

General procedure: Intermediates 10-17 were prepared following literature methods [49] with slight modifications. 2-Benzoxazolone 8 or 2-benzothiazolone 9 (7.4mmol), appropriate 1-omega-dibromoalkane (8mmol), potassium carbonate (8mmol) and acetone (10mL) were refluxed for 4h and then allowed to stand at room temperature. The mixture was filtered to eliminate inorganic material and then evaporated under reduced pressure to obtain a residue, which was taken up in water. The solution was extracted with dichloromethane (3¡Á50 mL) and the combined extracts were washed with water, dried, and evaporated. The residue was triturated twice with light petroleum ether 40-60C to give intermediates 10-17 that were used without further purification in the subsequent steps. Analytical and spectral data are reported only for unknown compounds 13 and 17.

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

Reference£º
Article; Salerno, Loredana; Pittala, Valeria; Modica, Maria N.; Siracusa, Maria A.; Intagliata, Sebastiano; Cagnotto, Alfredo; Salmona, Mario; Kurczab, Rafa?; Bojarski, Andrzej J.; Romeo, Giuseppe; European Journal of Medicinal Chemistry; vol. 85; (2014); p. 716 – 726;,
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59-49-4, 2-Benzoxazolinone is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 251A 6-bromo-1,3-benzoxazol-2(3H)-one A mixture of 2-benzoxazolinone (3.00 g, 22.2 mmol), 1,3-dibromo-5,5-dimethylhydantoin (3.49 g, 12.2 mmol), and trifluoromethanesulfonic acid (5.00 g, 33.3 mmol) in dichloromethane (100 mL) at room temperature was protected from light, stirred for 1 hour, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product., 59-49-4

As the paragraph descriping shows that 59-49-4 is playing an increasingly important role.

Reference£º
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/55631; (2002); A1;,
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4570-41-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4570-41-6,Benzo[d]oxazol-2-amine,as a common compound, the synthetic route is as follows.

1.34 g (10 mmol) benzo [d] oxazol-2-amine and3.07 g (10 mmol) of 1- (2,2-dibromovinyl) -2-nitrobenzene was dissolved in80 mL of dimethylformamide (DMF)Then stirred at a temperature of 120 ¡ã C for about 12 hours.The resulting reaction solution was cooled to room temperature.The organic layer was then extracted three times with 30 mL of water and 30 mL of ethyl acetate.The collected organic layer was dried with magnesium sulfate and the solvent was evaporated.The resulting residue was separated and purified by silica gel column chromatography, thereby completing the preparation of 1.87 g (75percent) of the intermediate I-1.

As the paragraph descriping shows that 4570-41-6 is playing an increasingly important role.

Reference£º
Patent; Sanxing Display Co., Ltd.; Po Junhe; Jin Rongguo; Shen Wenji; Li Xiaorong; Zheng Enzai; Huang Xihuan; (110 pag.)CN107522719; (2017); A;,
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Benzo[d]oxazole-2-thiol, cas is 2382-96-9, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,2382-96-9

General procedure: To a solution of 1 mmol of thiol in acetonitrile (2mL), was added a solution of 8 mL of phosphate buffer including laccase (40 U) and 4-phenyl urazole (10 mol%). The resulting mixture was stirred under air at room temperature for the time specified. After completion of the reaction (monitored by TLC), NaOH (10%, 10 mL). The combined organic phases were dried over anhydrous Na2SO4, filtered and evaporated under reduced pressure. The crude products were purified by recrystallization or chromatography on silica gel (n-hexane/EtOAc, 5/1). All the products were known and characterized by comparison of their spectral data (1H NMR) and physical properties (melting point) with those of authentic samples.

With the rapid development of chemical substances, we look forward to future research findings about 2382-96-9

Reference£º
Article; Khaledian, Donya; Rostami, Amin; Zarei, Seyed Amir; Catalysis Communications; vol. 114; (2018); p. 75 – 78;,
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2382-96-9, Benzo[d]oxazole-2-thiol is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2 (Compound No. 8 in Table) Production of 9-(benzoxazol-2-ylthio)-N-(2-methylthio-3-pyridyl)nonanamide: The reaction and the treatment were conducted in the same manner as in Example 1 except that 9-bromononanoyl chloride was used instead of 6-bromohexanoyl chloride to obtain 9-bromo-N-(2-methylthio-3-pyridyl)nonanamide. To a DMF (5 ml) solution of this amide (90 mg, 0.25 mmol) and 2-mercaptobenzoxazole (38 mg, 0.25 mmol) were added potassium carbonate (42 mg, 0.30 mmol) and 18-crown-6 (7 mg, 0.03 mmol), and the mixture was stirred at 80C for 3 hours. The reaction mixture was allowed to cool, and then extracted with ethyl acetate. The organic layer was washed with water and then with a saturated aqueous solution of sodium chloride, and dried over sodium sulfate. Subsequently, the solvent was distilled off, and the resulting residue was recrystallized from a mixture of ethyl acetate-hexane to obtain 83 mg (yield 77%) of the desired compound as a colorless powdery crystal. Melting point: 84 – 85C IR (KBr) cm-1:3465, 3276, 2926, 1664, 1505., 2382-96-9

As the paragraph descriping shows that 2382-96-9 is playing an increasingly important role.

Reference£º
Patent; KOWA COMPANY LTD.; EP979823; (2000); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73101-74-3,2-(Bromomethyl)benzo[d]oxazole,as a common compound, the synthetic route is as follows.

73101-74-3, (Step A-1) 53.2 mg of sodium hydride (as a 60% w/w dispersion in mineral oil) were added to a solution of 200.0 mg of 4-acetamido-3-methylphenol in 10 ml of dimethylformamide cooled in an ice-water bath. The resulting mixture was stirred at the same temperature for 5 minutes, and then 307.9 mg of 2-bromomethylbenzoxazole ?prepared as described in Example 28(a) above! were added. The temperature of the resulting mixture was elevated to room temperature and the mixture was stirred for 30 minutes. At the end of this time, the temperature of the reaction mixture was elevated to 50 C. and the mixture was stirred for a further 1.5 hours. At the end of this time, a saturated aqueous ammonium chloride solution was added to the reaction mixture and the resulting mixture was extracted with ethyl acetate. The resulting extract was washed consecutively with water and a saturated aqueous sodium chloride solution and then dried over anhydrous sodium sulfate. The solvent was then removed by evaporation under reduced pressure to give a crude crystalline solid which was purified by column chromatography through silica gel using a 3:1 by volume mixture of ethyl acetate and hexane as the eluent, to give 218.5 mg (yield 61%) of the title compound as a solid having a melting point of 160 C. Nuclear Magnetic Resonance Spectrum, (200 MHz, CDCl3) delta ppm: 7.78-7.74 (1H, multiplet); 7.58-7.51 (2H, multiplet); 7.39-7.34 (1H, multiplet); 6.92-6.84 (3H, multiplet); 5.30 (2H, singlet); 2.24 (3H, singlet); 2.18 (3H, singlet).

73101-74-3 2-(Bromomethyl)benzo[d]oxazole 12745944, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; Sankyo Company, Limited; US5736487; (1998); A;,
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701-16-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.701-16-6,5-Fluoro-2-methylbenzo[d]oxazole,as a common compound, the synthetic route is as follows.

[0552] To a stirred solution of Comp-48e (0.27 g, 1.32 mmol) and Comp-50c (0.2 g, 1.32 mmol) in THF:t-BuOH (5 mL 4:1) was added f-BuOK (0.15 g, 1.32 mmol) at 0 C and the reaction mixture was stirred at RT for 2 h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was poured on crushed ice and extracted with EtOAc (30 mL X 2). The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude compound was purified by column chromatography (silica, 100-200 mesh, 30-40% EtOAc in hexane) to afford (E)-5-fluoro-2-(2-(5-methyl-l-(l-methylpiperidin-4-yl)-lH-pyrazol-4- yl)vinyl)benzo[d]oxazole (78, 0.07 g, 15%) as pale yellow solid. (0972) [0553] HPLC purity : 99.89% (0973) [0554] MS (ESI) m/e [M+H]+/Rt %: 341.15/1.22/99.6% (0974) [0555] 1H NMR (400 MHz, DMSO-d6) delta 1.80 (d, .7=11.25 Hz, 2 H), 2.01 – 2.07 (m, 2 H), 2.08 – 2.17 (m, 2 H), 2.25 (s, 3H), 2.42 (s, 3 H), 2.91 (d, J=8.80 Hz, 2 H), 4.12 – 4.23 (m, 1 H), 6.91 (d, J=16.14 Hz, 1 H), 7.17-7.23 (m, 1 H), 7.54 (dd, J=9.05, 2.69 Hz, 1 H), 7.64 (d, J=16.14 Hz, 1 H), 7.69 (dd, J=8.80, 4.40 Hz, 1 H), 8.05 (s, 1 H).

As the paragraph descriping shows that 701-16-6 is playing an increasingly important role.

Reference£º
Patent; ALPINE ANDROSCIENCES, INC.; PATIL, Santhosh N.; SARMA, Bugga VNBS; (148 pag.)WO2019/152731; (2019); A1;,
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81900-93-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81900-93-8,4-Aminobenzo[d]oxazol-2(3H)-one,as a common compound, the synthetic route is as follows.

Amine 2d (362 mg, 3.8 mmol) (Scheme 7) was dissolved in 20 ml of AcOEt and at 0C triphosgene (1.12 g, l equiv.) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5 ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound lb (384 mg, 2.56 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 200 mg of a pale rose solid. Yield = 18% ‘HNMR (DMSO, 400 MHz) delta 2.91 (4H, m), 3.76 (4H, m), 4.46 (2H, d, J = 5.6 Hz), 6.97 (3H, m), 7.05 (1H, m), 7.36 (1H, s), 7.46 (1H, d), 7.54 (1H, d), 8.53 (1H, s), 1 1.00 (1H, bs); [M+1] 437.1 (C2oH19F3N4O4 requires 436.4).

81900-93-8 4-Aminobenzo[d]oxazol-2(3H)-one 19982202, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca; WO2011/120604; (2011); A1;,
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2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4

A reactor was charged with l,3-benzoxazol-2(3H)-one (309 mg) and a 2.5M solution of sodium hydroxide (1.5 g) in water (15 ml). The reactor heated to 100 C and held for 16 hours. The reaction mixture was cooled to ambient temperature then acidified to pH 1 with concentrated hydrochloric acid. The organics were then extracted with ethyl acetate (20 ml). The aqueous phase was basified with 10% aqueous sodium bicarbonate solution to pH 9 and then the organics were extracted with ethyl acetate (3 x 20 ml). The combined organic phase was dried (MgS04), filtered and reduced to an oil by rotary evaporation. This was purified by flash chromatography, eluting with n-hexane and ethyl acetate.Appropriate fractions were collected for the product peak and were reduced by rotary evaporation to obtain the desired product as orange oil (180 mg, 72%). The structure was confirmed as 2-aminophenol by 1H NMR

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

Reference£º
Patent; NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO; CROCKATT, Marc; URBANUS, Jan Harm; KONST, Paul Mathijs; DE KONING, Martijn Constantijn; (58 pag.)WO2016/114668; (2016); A1;,
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