Day: October 21, 2020

Name is 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 3889-13-2, its synthesis route is as follows.,3889-13-2

EXAMPLE 3 8-(5-Nitro-2-oxo-benzoxazolin-3-yl)-caprylic acid methyl ester The product is produced as described in example 1 from 6 g. of NaH (80% suspension in mineral oil), 36 g. of 5-nitrobenzoxazolin-2-one (produced in usual manner by reacting 2-amino-4-nitrophenol-hydrochloride with phosgene), 400 cc. of DMF, 47.4 g. of 8-bromo caprylic acid methyl ester and 6 g. of NaJ. Yield: 25 g. Fp.: 50 to 51 C. IR (film): 1780 and 1730 cm-1.

With the complex challenges of chemical substances, we look forward to future research findings about 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one

Reference£º
Patent; A. Nattermann & Cie GmbH; US4377695; (1983); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

2-Methylbenzo[d]oxazol-6-amine, cas is 5676-60-8, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,5676-60-8

General procedure: To a solution of compound 3 (3.37 mmol) in DMF (10 mL), charged respective compound V (a-p) (4.04 mmol) and heated to 80 C. After3 h, TLC analysis showed complete conversion of starting materials. The reaction mixture was cooled to room temperature, charged water (30 mL) and extracted with EtOAc (2 ¡Á 20 mL). The combined organic layer was washed with water (20 mL) followed by brine and concentrated under reduced pressure to obtain gummy liquid. This crude material was triturated with MTBE to afford desired product as solid and which used as such in next step without any further purification.

As the rapid development of chemical substances, we look forward to future research findings about 5676-60-8

Reference£º
Article; Balraju, Vadla; Jogula, Sridhar; Krishna, Vagolu Siva; Meda, Nikhila; Sriram, Dharmarajan; Bioorganic Chemistry; vol. 100; (2020);,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59-49-4,2-Benzoxazolinone,as a common compound, the synthetic route is as follows.

70% Nitric acid (50?mL, 0.80?mol) was cooled to 0?C and 3H-1,3-benzoxazol-2-one (5.00?g, 37?mmol) was added. The reaction mixture was stirred at rt for 4?h and then poured in ice.The resulting precipitate was collected by filtration, washed with water and dried to give a pink solid (5.80?g, 32.5?mmol, 87%). Mp?>?250?C. 1H NMR (300?MHz, DMSOd6): delta 12.41 (s, 1H), 8.20 (d, J?=?2.2?Hz, 1H), 8.13 (dd, J?=?8.6?Hz, J?=?2.2?Hz, 1H), 7.28 (d, J?=?8.6?Hz, 1H).13C NMR (300?MHz, DMSOd6): delta 154.7, 143.2, 142.5, 137.2, 121.2, 109.8, 105.8. LCMS m/z calc for [M?-?H]+: 179.0, found: 179.0., 59-49-4

As the paragraph descriping shows that 59-49-4 is playing an increasingly important role.

Reference£º
Article; Gay, Marion; Evrard, Caroline; Descamps, Florian; Carato, Pascal; Renault, Nicolas; Coevoet, Mathilde; Eddarkaoui, Sabiha; Baud, Catherine; Larchanche, Paul-Emmanuel; Buee, Luc; El Bakali, Jamal; Vingtdeux, Valerie; Sergeant, Nicolas; Melnyk, Patricia; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 104 – 125;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.177492-52-3,Benzo[d]oxazol-6-amine,as a common compound, the synthetic route is as follows.

A solution of benzo[djoxazol-6-amine (0.500 g, 3.727 mmol), methanesulfonyl chloride (0.317 mL, 4.100 mmol) and triethylamine (0.779 mL, 5.591 mmol) in dichloromethane (3 mL) was stirred at the room temperature for 3 hr. Then, water was added to the reaction mixture, followed by extraction with dichloromethane. The organic layer was washed with aqueous saturated sodium chloride solution, dried with anhydrous Mg504, filtered, and concentrated in vacuo. The residue was chromatographed (5i02, 4 g cartridge; ethyl acetate / hexane = 0 % to 50 %) to give N(benzo[djoxazol-6-yl)methanesulfonamide as purple solid (0.351 g, 44.4 %).

177492-52-3, As the paragraph descriping shows that 177492-52-3 is playing an increasingly important role.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; HAN, Younghue; KIM, Yuntae; CHOI, Daekyu; MIN, Jaeki; BAE, Miseon; YANG, Hyunmo; KIM, Dohoon; (644 pag.)WO2017/18803; (2017); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3889-13-2,5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one,as a common compound, the synthetic route is as follows.

General procedure: The resulting benzoxazolone (1 equiv.), 2-dibromobutane (1.5 equiv) and potassium carbonate (1.5 equiv.) were suspended in anhydrous DMF and stirred at ambient temperature and under a nitrogen atmosphere for 8 h. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel chromatograph. See title compounds for characterisation., 3889-13-2

The synthetic route of 3889-13-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tieu, William; Jarrad, Angie M.; Paparella, Ashleigh S.; Keeling, Kelly A.; Soares Da Costa, Tatiana P.; Wallace, John C.; Booker, Grant W.; Polyak, Steven W.; Abell, Andrew D.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 19; (2014); p. 4689 – 4693;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

2382-96-9, Benzo[d]oxazole-2-thiol is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Boehmite-SSA (0.002 g) was added to a mixture of thiol(1 mmol) and H2O2 (0.4 mL) in ethyl acetate (2 mL). Then,the mixture was stirred for the appropriate time at room temperature. The progress of reaction was monitored byTLC. After completion of the reaction, the catalyst was separated by filtration and the mixture was washed with ethyl acetate. The product was extracted with ethyl acetate.The organic layer was dried over anhydrous Na2SO4(1.5 g). The products were obtained in good to high yield., 2382-96-9

As the paragraph descriping shows that 2382-96-9 is playing an increasingly important role.

Reference£º
Article; Ghorbani-Choghamarani, Arash; Hajjami, Maryam; Tahmasbi, Bahman; Noori, Nourolah; Journal of the Iranian Chemical Society; vol. 13; 12; (2016); p. 2193 – 2202;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

19932-85-5, 6-Bromobenzo[d]oxazol-2(3H)-one is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 6. 2-oxo-2,3-dihydro-1 ,3-benzoxazole-6-carbonitrileA mixture of 6-bromo-1 ,3-benzoxazol-2(3H)-one (2 g ; 9.34 mmol) and copper (I ) cyan ide (1 .42 g; 1 5.86 mmol) in 6 m l D M F is heated at 1 50C u nder nitrogen atmosphere for 22 hr. After cooling to room temperature, a solution of 1 .55 g (31 .6 mmol) of sodium cyanide in 32 ml water is added followed by 1 hr stirring. The system is extracted thoroughly with ethyl acetate, washed with brine, dried and concentrated in vacuo to provide 1 .5 g (93 % yield) of the title compound enough pure as to prosecute the syntesis., 19932-85-5

The synthetic route of 19932-85-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ALMIRALL, S.A.; AIGUADE BOSCH, Jose; GUAL ROIG, Silvia; PRAT QUINONES, Maria; PUIG DURAN, Carlos; WO2013/68554; (2013); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO302,mainly used in chemical industry, its synthesis route is as follows.,73101-74-3

General procedure: A mixture of 1-alkyl benzimidazole (1.0mmol) and 11 2-bromomethyl-1,3-benzoxazole (0.21g, 1.0mmol) was stirred at 100C for 24h in 13 1,4-dioxane. The light brown precipitate yielded was separated by filtration and washed with fresh 1,4-dioxane (3¡Á10mL) to obtain the corresponding 64 bromide salt (5a-b).

With the synthetic route has been constantly updated, we look forward to future research findings about 2-(Bromomethyl)benzo[d]oxazole,belong benzoxazole compound

Reference£º
Article; Shahini; Achar, Gautam; Budagumpi, Srinivasa; Mueller-Bunz, Helge; Tacke, Matthias; Patil, Siddappa A.; Journal of Organometallic Chemistry; vol. 868; (2018); p. 1 – 13;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is Benzo[d]oxazole-2-thiol, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 2382-96-9, its synthesis route is as follows.,2382-96-9

General procedure: A mixture of thiol (1 mmol), 33 % H2O2 (0.4 mL) and Fe3O4MCM-41VO-SPATB (10 mg) in ethanol (3 mL) was stirred for the specified time at ambient temperature (the progress of reaction was monitored by TLC). After completion of the reaction, the catalyst was separated by applying an external magnet and the product was washed with ethyl acetate, and then dried over anhydrous Na2SO4 (1.5 g). Finally, Evaporation of the solvent gave the disulfides invery high isolated yields

With the complex challenges of chemical substances, we look forward to future research findings about Benzo[d]oxazole-2-thiol

Reference£º
Article; Nikoorazm, Mohsen; Ghorbani, Farshid; Ghorbani-Choghamarani, Arash; Erfani, Zahra; Journal of the Iranian Chemical Society; vol. 16; 3; (2019); p. 553 – 562;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

701-16-6, 5-Fluoro-2-methylbenzo[d]oxazole is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,701-16-6

(b) 5-Fluoro-2-methyl-6-nitrobenzo[d]oxazole (2667) To a solution of 5-fluoro-2-methylbenzo[d]oxazole (1 .65 g) in sulfuric acid (10 ml) was added a mixture of nitric acid (2.5 m) and sulfuric acid (2.5 ml) at 0 C. The reaction was allowed to stir at room temperature for 30 minutes whereupon LCMS indicated complete conversion. After 1 hour, the reaction was slowly poured onto crushed ice then diluted with water. After stirring 20 minutes, the solids were collected, rinsed well with water, and suction dried to afford the titled compound (1 .85 g) as a pink solid. LCMS m/z = 196.9 [M+H]. NMR (400 MHz, DMSO-d6) delta ppm 2.71 (s, 3H), 7.97 (d, J=1 1 .12 Hz, 1 H), 8.64 (d, J=6.32 Hz, 1 H).

As the paragraph descriping shows that 701-16-6 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; ATOR, Laura E.; DUFFY, Kevin J.; GRAYBILL, Todd L.; KIESOW, Terence John; LIAN, Yiqian; MOORE, Michael Lee; RALPH, Jeffrey M.; RIDGERS, Lance Howard; (370 pag.)WO2017/98421; (2017); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem