Day: November 12, 2020

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO363,mainly used in chemical industry, its synthesis route is as follows.,4570-41-6

General procedure: A mixture of 6a/6b/6c/7a/7b/7c (1 mmol),benzoxazol-2-amine (2a)/benzothiazol-2-amine (2b)/1Hbenzimidazol-2-amine (2c)/(benzoxazol-2-yl)methanamine(3a)/(benzothiazol-2-yl) methanamine (3b)/(1H-benzimidazol-2-yl)methanamine (3c) (1.1 mmol), dry ethanol (4 ml)and a catalytic amount of methanesulfonic acid (0.2 ml) wasrefluxed for 6?7 h. The contents of the flask were cooledand diluted with water (15 ml). The separated solid wasfiltered, washed with water, dried and recrystallized from 2-propanol. N-(1,3-Benzoxazol-2-yl)-N?-[4-(1,3-benzoxazol-2-ylamino)-6-methyl-2-pyrimidinyl]sulfamide (9a)Red solid; yield (method A 65percent and method B 84percent); m.p.175?177 ¡ãC; IR (KBr) vmax 3367 (NH), 1583 (C=N), 1333(SO2), 1163 cm?1; 1H NMR (DMSO?d6, 400 MHz): delta =2.67 (s, 3H, CH3), 7.38 (s, 1H, C5?H), 7.47?7.69 (m, 8H,Ar?H), 8.45 (bs, 1H, NH?C2?), 8.63 (bs, 1H, NH?C2?), 8.70(bs, 1H, C2?NH); 13C NMR (DMSO?d6, 100MHz): delta =27.1 (CH3), 97.6 (C?5), 154.6 (C?2?), 161.3 (C?2?), 168.4(C?6), 171.3 (C?2), 172.3 (C?4), 113.3, 113.7, 122.6,122.9, 126.5, 126.8, 127.4, 127.9, 143.9, 144.4, 153.3, 153.8 (aromatic carbons); MS (m/z): 437.45 [M+]. Anal.Calcd. for C19H15N7O4S: C, 52.17; H, 3.46; N, 22.41.Found: C, 52.29; H, 3.50; N, 22.58.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo[d]oxazol-2-amine,belong benzoxazole compound

Reference£º
Article; Seenaiah, Dandu; Rekha, Tamatam; Padmaja, Adivireddy; Padmavathi, Venkatapuram; Medicinal Chemistry Research; vol. 26; 2; (2017); p. 431 – 441;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

4-Aminobenzo[d]oxazol-2(3H)-one, cas is 81900-93-8, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,81900-93-8

Commercially available 4-chloro-2-trifluoromethylbenzylamine (1 g, 4.77 mmol) was dissolved in 20ml of AcOEt and at 0C triphosgene (1.41 g, 4.77 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5 ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (5 ml) of compound lb (475 mg, 3.2 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 4 / petroleum ether 6). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 120 mg of a white solid. Yield = 9.7% rHNM (DMSO,200 MHz) delta 4.45 (2H, d, J = 5.6 Hz), 6.99 (4H, m), 7.65 (1H, d), 7.73 (1H, d), 7.85 (1H, bs), 8.62 (1H, bs), 1 1.04 (1H, bs); [M+1] 386.6 (C16HnClF3N3O3 requires 385.73).

With the rapid development of chemical substances, we look forward to future research findings about 4-Aminobenzo[d]oxazol-2(3H)-one

Reference£º
Patent; PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca; WO2011/120604; (2011); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is 6-Bromobenzo[d]oxazol-2(3H)-one, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 19932-85-5, its synthesis route is as follows.,19932-85-5

Intermediate 1.3-al IyI-2-oxo-2,3-dihydro-1 ,3-benzoxazole-6-carbonitrileTo a solution of 2-oxo-2,3-dihydrobenzo[d]oxazole-6-carbonitrile (210mg, 1.31 mmol, that product was synthesized by a mixture of 6-bromo-1 ,3-benzoxazol-2(3H)-one (2 g; 9.34 mmol) and copper (I) cyanide (1.42 g; 15.86 mmol) in 6 ml DMF, heated at 150C under nitrogen atmosphere for 22 hr. After cooling to room temperature, a solution of 1 .55 g (31 .6 mmol) of sodium cyanide in 32 ml water is added followed by 1 hr stirring. The system is extracted thoroughly with ethyl acetate, washed with brine, dried and concentrated in vacuum) in acetonitrile (4mL) was added potassium carbonate (362mg, 2.62mmol) and potassium iodide (43mg, 0.26mmol) in a sealed tub. Then 3- bromoprop-1-ene (0.9mL, 10.4mmol) was added to the reaction. The mixture was stirred overnight at 70C. The solid residue was filtrated through Celite. The solvent of the filtrate was removed under reduced pressure and the crude obtained was treated with ether giving a solid (1 50mg, 57% yield), which was used in the next step without further purification.LRMS (m/z): 201 (M+1)+.

With the complex challenges of chemical substances, we look forward to future research findings about 6-Bromobenzo[d]oxazol-2(3H)-one

Reference£º
Patent; ALMIRALL, S.A.; SOLE FEU, Laia; CARRANCO MORUNO, Ines; AIGUADE BOSCH, Jose; PUIG DURAN, Carlos; FONQUERNA POU, Silvia; WO2014/95920; (2014); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is Benzo[d]oxazol-6-amine, and cas is 177492-52-3, its synthesis route is as follows.,177492-52-3

General procedure: A mixture of the appropriate amine (1M-3M, 2 mmol) and the appropriate aldehyde (2.2 mmol) in ethanol (10 mL) was stirred at room temperature for 8 h.

With the complex challenges of chemical substances, we look forward to future research findings about 177492-52-3,belong benzoxazole compound

Reference£º
Article; Zhang, Da-Jun; Sun, Wen-Fang; Zhong, Zhao-Jin; Gao, Rong-Mei; Yi, Hong; Li, Yu-Huan; Peng, Zong-Gen; Li, Zhuo-Rong; Molecules; vol. 19; 1; (2014); p. 925 – 939;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

19932-85-5, 6-Bromobenzo[d]oxazol-2(3H)-one is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The crude product above (2.0mmol) was dissolved in DMF (20mL). The corresponding benzo[d]oxazol-2(3H)-one (2.4mmol) and Cs2CO3 (782mg, 2.4mmol) was added to the solution. The reaction mixture was stirred at 50C for 5h and then cooled to room temperature. The mixture was diluted with water (40mL) and then was extracted with ethyl acetate (20mL¡Á3). The combined organic layer was washed by saturated sodium chloride solution for three times, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel chromatography to afford 11. White solid (35%, 4 steps). 1H NMR (300MHz, CDCl3) delta 8.64 (d, J=5.3Hz, 1H), 7.82 (d, J=9.2Hz, 1H), 7.37 (ddd, J=9.3, 5.7, 2.3Hz, 3H), 7.13-7.02 (m, 2H), 6.60 (t, J=5.7Hz, 1H), 4.49 (dd, J=9.0, 3.9Hz, 2H), 4.35 (t, J=5.0Hz, 2H), 3.92 (s, 3H). MS (ESI): 415.0, 417.1 [M+H]+. Purity: >95%

19932-85-5, The synthetic route of 19932-85-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lu, Dong; Shen, Aijun; Liu, Yang; Peng, Xia; Xing, Weiqiang; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 191 – 200;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Benzo[d]oxazol-2-amine, cas is 4570-41-6, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,4570-41-6

Example 1 ethyl 6-hydroxy-4-oxo-1,2-dihydro-4H-pyrrolo [3,2,1-ij] quinoline-5-carboxylate (130 mg, 0.50 mmol) and benzo[d]oxazol-2-amine (80 mg, 0.60 mmol) is dissolved in DMF (2 mL) and placed in a sealed tube, heated at 160C for 30 minutes, Cooled slowly to room temperature. The resulting solid was filtered and washed with ethanol to give the target compound (KCNS-SM-31); 73 mg, 42% yield).

As the rapid development of chemical substances, we look forward to future research findings about 4570-41-6

Reference£º
Patent; Korea Research Institute of Chemical Technology; Park Cheol-min; Lee Seon-gyeong; Song Jong-hwan; (39 pag.)KR2019/67546; (2019); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 2-Benzoxazolinone, and cas is 59-49-4, its synthesis route is as follows.,59-49-4

Preparation of 6-Bromo-3H-benzoxazol-2-one. To a stirred suspension of 3H-benzoxazol-2-one (1.35 g, 10 mmol) in acetonitrile (23 ML) at -15 C. was added portionwise NBS (2.00 g, 11.0 mmol).Following complete addition of NBS the mixture was stirred at -15 to 0 C. for 3 h then allowed to warm to ambient temperature and stirred overnight.The solvent was evaporated in vacuo and the residue was partitioned between CH2Cl2/H2O precipitating the intermediate title compound, 6-bromo-3H-benzoxazol-2-one, (0.67 g, 31%) as a brown solid. 1HNMR(CDCl3) delta 7.0 (1H, d), 7.15 (1H.,d), 7.3 (1H, s), 11.9 (1H, s).

With the complex challenges of chemical substances, we look forward to future research findings about 59-49-4,belong benzoxazole compound

Reference£º
Patent; Bender, David Michael; Forman, Scott Louis; Jones, Winton Dennis; Smith, Daryl Lynn; Zarrinmayeh, Hamideh; Zimmerman, Dennis Michael; US2003/225127; (2003); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

4-Aminobenzo[d]oxazol-2(3H)-one, cas is 81900-93-8, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,81900-93-8

Amine 2b (289 mg, 1.2 mmol) (Scheme 7) was dissolved in 20ml of AcOEt and at 0C triphosgene (356 mg, 1.2 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound lb (180 mg, 1.2 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave lOOmg of a white solid. Yield = 20% ‘HNMR (DMSO, 200 MHz) delta 1.94 (4H, m), 3.23 (4H, m), 4.67 (2H, d, J = 5.6 Hz), 6.55 (2H, dd, J = 8.8 Hz, J’ = 1.2 Hz), 7.05 (1H, t, J = 8.2 Hz), 7.17 (2H, d, J = 7.2 Hz), 7.46 (1H, d), 9.98 (1H, t), 1 1.53 (1H, bs), 1 1.80 (1H, bs); [M+1] 421.2 (C2oH19F3N4O3 requires 420.39).

As the rapid development of chemical substances, we look forward to future research findings about 81900-93-8

Reference£º
Patent; PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca; WO2011/120604; (2011); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is 2-Benzoxazolinone, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 59-49-4, its synthesis route is as follows.,59-49-4

Step 1: To a solution of benzoxazolinone (20 g, 0.148 mol) in 220 mL glacial acetic acid was added N-bromosuccinimide (NBS, 26.36 g, 0.148 mol), and the reaction mixture was stirred at room temperature for 63 hours before pouring into 1500 mL water. The precipitated product was washed thoroughly with water upon collection and recrystallized from EtOH to give 6-bromo-3H-benzoxazol-2-one (9) (25.09 g, 79%): Theory: C, 39.28; H, 1.88; N, 6.54; Br, 37.33. Found: C, 39.36; H, 2.02; N, 6.36; Br, 37.43. MP 192-194 C.

With the complex challenges of chemical substances, we look forward to future research findings about 2-Benzoxazolinone

Reference£º
Patent; Kornberg, Brian Edward; Lewthwaite, Russell Andrew; Manning, David; Nikam, Sham Shridhar; Scott, Ian Leslie; US2003/18021; (2003); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2382-96-9,Benzo[d]oxazole-2-thiol,as a common compound, the synthetic route is as follows.

General procedure: In another study, a mixture of the VO-AMPD(at)SBA-15 (0.004 g), thiol (1 mmol) and H2O2 (0.4 mL) was stirred at room temperature in ethyl acetate (2 mL). The progress was monitored by TLC. After completion of the reaction, VO-AMPD(at)SBA-15 catalyst was separated from the mixture by filtration. Then products were extracted with ethyl acetate and dried, and the solvent was removed to give the pure disulfides., 2382-96-9

2382-96-9 Benzo[d]oxazole-2-thiol 712377, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Article; Tamoradi, Taiebeh; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash; Molaei, Somayeh; Research on Chemical Intermediates; vol. 44; 7; (2018); p. 4259 – 4276;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem