Day: March 16, 2021

Name is Benzo[d]oxazole-2-thiol, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 2382-96-9, its synthesis route is as follows.

General procedure: A sealed tube (90 mL) equipped with a magnetic stirring bar and an O2 balloon was charged with dichloroethane (DCE, 20 mL), thiophenol (1a, 4 mmol, 0.44 g) and TBN (0.16 mmol, 4 mol%, 19.2 mL). Then the tube was placed in an oil bath, which was preheated to 50C. The mixture was stirred for 1 h until starting material was completely consumed as monitored by GC and TLC. After removing the solvent, the residue was purified by column chromatography on silica gel to give the desired diphenyl disulfide (2a, 90%, 0.394 g) as a white solid.

2382-96-9, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,2382-96-9 ,Benzo[d]oxazole-2-thiol, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Yi, Shan-Li; Li, Mei-Chao; Hu, Xin-Quan; Mo, Wei-Min; Shen, Zhen-Lu; Chinese Chemical Letters; vol. 27; 9; (2016); p. 1505 – 1508;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 4-Aminobenzo[d]oxazol-2(3H)-one, and cas is 81900-93-8, its synthesis route is as follows.

Example 29: 1-(2-(dimethylamino)-4-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-4-yl)urea scheme 1) Preparation of 1-(2-(dimethylamino)-4-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-4-yl)urea Amine 2a (1.2 g, 5.5 mmol) was dissolved in 40ml of AcOEt and at 0C triphosgene (1.63 g, 5.5 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5 ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound 1b (820 mg, 5.5 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 7 / petroleum ether 3). The solvent was evaporated and the crude was dissolved in AcOEt (50 ml) and washed with water (1 X 3 0ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 300 mg of a white solid. Yield = 14% 1HNMR (DMSO, 200 MHz) delta 2.51 (6H, s), 4.71 (2H, d, J = 5.6 Hz), 6.55 (2H, d, J = 8.2 Hz), 7.05 (1H, t, J = 7.6 Hz), 7.40 (1H, m), 7.51 (1H, d), 10.06 (1H, bt), 11.53 (1H, bs), 11.80 (1H, bs); [M+1] 395.1 (C18H17F3N4O3 requires 394.35).

81900-93-8, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,81900-93-8 ,4-Aminobenzo[d]oxazol-2(3H)-one, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Pharmeste S.r.l.; EP2377850; (2011); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is Benzo[d]oxazol-2-amine, and cas is 4570-41-6, its synthesis route is as follows.

The Schiff base, N-((thiophen-2-yl)methyleneimino)benzoxazole (Htbi) was isolated as an orange crystalline substance from the equimolar condensation reaction between 2-aminobenzoxazole (0.250 g; 1.86 mmol) and 2-thiophenecarboxaldehyde (0.209; 1.86 mmol). The reaction was conducted in 40 cm3 of dry toluene and in the presence 3 drops of piperidine, under nitrogen for 6 hours followed by reducing the reaction mixture to 5 cm3 and cooling it in an ice-bath to induce crystallization. The reducing agent, sodium borohydride (0.025 g, 0.66 mmol) in ethanol ethanol (10 cm3) was added dropwise to a stirring solution of ethanol (20 cm3) containing 0.15 g of Htbi (0.66 mmol) at room temperature. The reaction mixture was then refluxed for an hour and thereafter cooled to room temperature by adding an equal volume of cold distilled water. A white precipitate instantaneously formed which was collected, washed with distilled water and dried under vacuum. Yield = 88percent,

4570-41-6, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,4570-41-6 ,Benzo[d]oxazol-2-amine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Booysen, Irvin Noel; Adebisi, Abimbola; Akerman, Matthew Piers; Inorganica Chimica Acta; vol. 433; (2015); p. 13 – 20;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, and cas is 3889-13-2, its synthesis route is as follows.

General procedure: To a stirred suspension of benzo [d]oxazol-2(3H)-ones, anhydrousK2CO3 (1.2 mmol) was added in the dry DMF solvent for20 min at 60 C. Then chloroacetylated 3a-3e (1.3 mmol) and TBAI(0.1 mmol) were added simultaneously. The reaction was stirredand heated for 5 h. After completion, the mixture was extractedwith DCM/H2O three times. The combined organic layers werewashed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purifiedby silica gel column chromatography eluting with DCM/Methanol (20:1e10:1) to afford compounds D01-D08.

3889-13-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,3889-13-2 ,5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Yang, Lixin; Liu, Yongqing; Fan, Minghua; Zhu, Guiwang; Jin, Hongwei; Liang, Jing; Liu, Zhenming; Huang, Zhuo; Zhang, Liangren; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

17200-30-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6-Nitrobenzo[d]oxazole, cas is 17200-30-5,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

[0004031 To a stirred solution of compound 1 (0.6 g, 1 eq) in methanol (10 mL), Raney nickel (0.1 g) was added. The reaction mixture was stirred at room temperature under hydrogen atmosphere (balloon pressure) for 3 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was filtered through celite and evaporated under reduced pressure to afford the title compound 6. LCMS (mlz): 135.00 (M + 1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6-Nitrobenzo[d]oxazole, 17200-30-5

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; BHAGWAT, Shripad; WANG, Bing; LUEDTKE, Gregory R.; SPYVEE, Mark; (490 pag.)WO2016/57834; (2016); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is 2-Methylbenzo[d]oxazol-6-amine, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 5676-60-8, its synthesis route is as follows.

General procedure: To a solution of compound 3 (3.37 mmol) in DMF (10 mL), charged respective compound V (a-p) (4.04 mmol) and heated to 80 C. After3 h, TLC analysis showed complete conversion of starting materials. The reaction mixture was cooled to room temperature, charged water (30 mL) and extracted with EtOAc (2 ¡Á 20 mL). The combined organic layer was washed with water (20 mL) followed by brine and concentrated under reduced pressure to obtain gummy liquid. This crude material was triturated with MTBE to afford desired product as solid and which used as such in next step without any further purification.

5676-60-8, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,5676-60-8 ,2-Methylbenzo[d]oxazol-6-amine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Balraju, Vadla; Jogula, Sridhar; Krishna, Vagolu Siva; Meda, Nikhila; Sriram, Dharmarajan; Bioorganic Chemistry; vol. 100; (2020);,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 2-Chloro-6-fluorobenzo[d]oxazole, and cas is 153403-53-3, its synthesis route is as follows.

To a solution of N-[(/S,2S)-2-aminocyclopentyl]-3-methoxypyridine-2-carboxarnide hydrochloride (Intermediate 2; 75 mg, 0.28 mmol) and DIPEA (0.15 ml, 0.83 mmol) in DMSO (1 ml) was added 2-chloro-6-fluoro-l,3-benzoxazole (CAS number 153403-53-3; 57 mg, 0.33 mmol) and the reaction mixture was subjected to microwave irradiation at 140 C for 2 hours. The reaction mixture was partitioned between DCM and water. The organics were filtered through a hydrophobic frit and concentrated in vacuo. The crude material was purified by reverse phase preparative HPLC (eluted with acetonitrile / water containing 0.1 % ammonia) to afford the title compound. (0530) 1H NMR (DCM-ii2) delta ppm 1.66-1.82 (m, 2 H), 1.86-1.94 (m, 2 H), 2.21-2.32 (m, 1 H), 2.46-2.58 (m, 1 H), 3.91 (s, 3 H), 3.91 -3.99 (m, 1 H), 4.35-4.45 (m, 1 H), 6.55-6.66 (m, 1 H), 6.85-6.93 (m, 1 H), 6.98-7.02 (m, 1 H), 7.16-7.20 (m, 1 H), 7.45-7.56 (m, 2 H), 8.08- 8.19 (m, 1 H), 8.15-8.23 (m, 1 H) (0531) MS ES+: 371

153403-53-3, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,153403-53-3 ,2-Chloro-6-fluorobenzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; FUJIMOTO, Tatsuhiko; ROBINSON, John Stephen; WO2015/124934; (2015); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 5-Methyl-2-aminobenzoxazol, and cas is 64037-15-6, its synthesis route is as follows.

In 2500 ml of anhydrous toluene, succinic anhydride (Mol. Wt.: 100.07, 141.1 g, 1.41 mol) and 70 g (about 0.47 mol) of compound from Step 9a were added under stirred condition, and then the mixture was refluxed for overnight. After that, 100 g (0.26 mol) of HATU and 41.36 ml (0.376 mol) of 4-methylpholine were added and then the resulting mixture was refluxed for 2-3 hours. TLC showed that the major spot was product and its TLC RF value is about 0.45 in solution of acetone and hexane by the ratio of 1 to 2. After reaction was completed, the solvent was evaporated and the residues was dissolved in about 2000 ml of CH2Cl2, the solution was treated with aqueous NaHCO3 and CO2 was generated during stirring. After pH was adjusted to be about 7-8 and washed with brine, organic phase was separated and dried over MgSO4. Filtration and removal of solvent gave about 98 g of crude desired product as fine white needle crystalline. MS(ESI): m/e (M+H) 231.

64037-15-6, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,64037-15-6 ,5-Methyl-2-aminobenzoxazol, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Xu, Guoyou; Gai, Yonghua; Wang, Guoqlang; Or, Yat Sun; Wang, Zhe; US2007/207972; (2007); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 2-(Bromomethyl)benzo[d]oxazole, and cas is 73101-74-3, its synthesis route is as follows.

(Step A-1) 53.2 mg of sodium hydride (as a 60% w/w dispersion in mineral oil) were added to a solution of 200.0 mg of 4-acetamido-3-methylphenol in 10 ml of dimethylformamide cooled in an ice-water bath. The resulting mixture was stirred at the same temperature for 5 minutes, and then 307.9 mg of 2-bromomethylbenzoxazole ?prepared as described in Example 28(a) above! were added. The temperature of the resulting mixture was elevated to room temperature and the mixture was stirred for 30 minutes. At the end of this time, the temperature of the reaction mixture was elevated to 50 C. and the mixture was stirred for a further 1.5 hours. At the end of this time, a saturated aqueous ammonium chloride solution was added to the reaction mixture and the resulting mixture was extracted with ethyl acetate. The resulting extract was washed consecutively with water and a saturated aqueous sodium chloride solution and then dried over anhydrous sodium sulfate. The solvent was then removed by evaporation under reduced pressure to give a crude crystalline solid which was purified by column chromatography through silica gel using a 3:1 by volume mixture of ethyl acetate and hexane as the eluent, to give 218.5 mg (yield 61%) of the title compound as a solid having a melting point of 160 C. Nuclear Magnetic Resonance Spectrum, (200 MHz, CDCl3) delta ppm: 7.78-7.74 (1H, multiplet); 7.58-7.51 (2H, multiplet); 7.39-7.34 (1H, multiplet); 6.92-6.84 (3H, multiplet); 5.30 (2H, singlet); 2.24 (3H, singlet); 2.18 (3H, singlet).

73101-74-3, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,73101-74-3 ,2-(Bromomethyl)benzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Sankyo Company, Limited; US5736487; (1998); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 2-Benzoxazolinone, and cas is 59-49-4, its synthesis route is as follows.

To a mixture of 3H-benzooxazol-2-one (20 g, 0.15 mol) in DCM (500 mL) was added bromine (8.34 mL, 0.16 mol). After stirring at room temperature for 19.5 h, the orange precipitate that had formed was filtered off and washed with DCM until the orange color was washed out. The filtrate was concentrated to approximately 33% of its original volume and filtered and washed as before. The combined solids weighed 28.36 g and contained ca. 8-9% starting material.

59-49-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,59-49-4 ,2-Benzoxazolinone, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/86705; (2006); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem