Month: June 2021

Name is 5-Fluoro-2-methylbenzo[d]oxazole, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 701-16-6, its synthesis route is as follows.

General procedure: The SBOs were prepared by the base-catalysed condensation of the appropriate 5-halogeno-2-methylbenzoxazole with the requisite aromatic aldehyde under phase transfer conditions. In a typical experiment, equimolar quantities (5 mmol) of the starting materials were dissolved in dichloromethane (20-50 ml) in the presence of benzyltriethylammonium chloride (3 mmol) and stirred magnetically under a nitrogen atmosphere as an aqueous solution of sodium hydroxide (50%, w/v, 5 ml) was added dropwise over a period of 10 min. After being stirred for 2-36 h until analytical thin layer chromatography indicated that the reaction was complete, the mixture was diluted with water (50 ml) and the SBO was extracted with dichloromethane (3×20 ml), dried (MgSO4), filtered, evaporated under reduced pressure and recrystallized from aqueous methanol or ethanol.

701-16-6, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,701-16-6 ,5-Fluoro-2-methylbenzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference：
Article; Ayrton, Stephen T.; Panova, Jekaterina; Michalik, Adam R.; Martin, William H.C.; Gallagher, Richard T.; Bowen, Richard D.; International Journal of Mass Spectrometry; vol. 345-347; (2013); p. 120 – 131;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is 6-Bromobenzo[d]oxazole, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 375369-14-5, its synthesis route is as follows.

6-Bromobenzo[d]oxazole (0.600 g, 3.03 mmol), anhydrous potassium acetate (0.595 g, 6.06 mmol) and 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (0.846 g, 3.33 mmol) were combined in dry dioxane (10 mL), and the mixture was sparged with nitrogen for 15 min. The reaction mixture was treated with Pd(dppf)Cl2 (0.124 mg, 0.152 mmol) and was heated to 90C for 16 h After cooling, the mixture was shaken with EtOAc (45 mL) and satd NaCl (10 mL) and was filtered to remove dark solids. The organic phase was dried and concentrated. Purification by silica gel chromatography with 0-30% EtOAc-hexane afforded the title compound as white crystals (600 mg, 74%): mp 79-81 C; NMR (400 MHz, CDCl3) delta 8.13 (s, 1H), 8.04 (s, 1H), 7.80 (qt, / = 3.3, 1.8 Hz, 2H), 1.37 (s, 12H); EIMS m/z 245.

375369-14-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,375369-14-5 ,6-Bromobenzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference：
Patent; DOW AGROSCIENCES LLC; BELL, Jared; BUYSSE, Ann M.; DAEUBLE, John F.; ECKELBARGER, Joseph D.; EPP, Jeffrey B.; IRVINE, Nicholas M.; KISTER, Jeremy; LO, William C.; LOSO, Michael R.; LOWE, Christian T.; ROHANNA, John C.; SATCHIVI, Norbert M.; SIDDALL, Thomas L.; STEWARD, Kimberly M.; YERKES, Carla N.; (281 pag.)WO2019/84353; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is Benzo[d]oxazole-2-thiol, and cas is 2382-96-9, its synthesis route is as follows.

General procedure: A mixture of 2-mercaptobenzoxazole (2a, X = O), 2-mercaptobenzthiazole (2b,X = S) (10 mmol), 2-chloroacetic acid (10 mmol), K2CO3 (10 mmol), DMF (10 mL),and TBAB as a PTC was stirred for 1-2 h at r.t. After completion of reaction, the mixturewas cooled to r.t. and treated with acetic acid until neutralized. The separated solid wasfiltered, washed with water (2 × 40 mL), and dried to obtain crude 3a,b. The latter onrecrystallization from suitable solvent gave pure 3a,b.

2382-96-9, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,2382-96-9 ,Benzo[d]oxazole-2-thiol, other downstream synthetic routes, hurry up and to see

Reference：
Article; Rafeeq, Mohammad; Ramana Reddy, Chittireddy Venkata; Dubey, Pramod Kumar; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 11; (2015); p. 1857 – 1864;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is Benzo[d]oxazol-2-amine, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 4570-41-6, its synthesis route is as follows.

Example 1 ethyl 6-hydroxy-4-oxo-1,2-dihydro-4H-pyrrolo [3,2,1-ij] quinoline-5-carboxylate (130 mg, 0.50 mmol) and benzo[d]oxazol-2-amine (80 mg, 0.60 mmol) is dissolved in DMF (2 mL) and placed in a sealed tube, heated at 160C for 30 minutes, Cooled slowly to room temperature. The resulting solid was filtered and washed with ethanol to give the target compound (KCNS-SM-31); 73 mg, 42% yield).

4570-41-6, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,4570-41-6 ,Benzo[d]oxazol-2-amine, other downstream synthetic routes, hurry up and to see

Reference：
Patent; Korea Research Institute of Chemical Technology; Park Cheol-min; Lee Seon-gyeong; Song Jong-hwan; (39 pag.)KR2019/67546; (2019); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

64037-15-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5-Methyl-2-aminobenzoxazol, cas is 64037-15-6,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

In 2500 ml of anhydrous toluene, succinic anhydride (Mol. Wt.: 100.07, 141.1 g, 1.41 mol) and 70 g (about 0.47 mol) of compound from Step 9a were added under stirred condition, and then the mixture was refluxed for overnight. After that, 100 g (0.26 mol) of HATU and 41.36 ml (0.376 mol) of 4-methylpholine were added and then the resulting mixture was refluxed for 2-3 hours. TLC showed that the major spot was product and its TLC RF value is about 0.45 in solution of acetone and hexane by the ratio of 1 to 2. After reaction was completed, the solvent was evaporated and the residues was dissolved in about 2000 ml of CH2Cl2, the solution was treated with aqueous NaHCO3 and CO2 was generated during stirring. After pH was adjusted to be about 7-8 and washed with brine, organic phase was separated and dried over MgSO4. Filtration and removal of solvent gave about 98 g of crude desired product as fine white needle crystalline. MS(ESI): m/e (M+H) 231.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5-Methyl-2-aminobenzoxazol, 64037-15-6

Reference：
Patent; Xu, Guoyou; Gai, Yonghua; Wang, Guoqlang; Or, Yat Sun; Wang, Zhe; US2007/207972; (2007); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is Methyl 2-mercaptobenzo[d]oxazole-6-carboxylate, and cas is 72752-81-9, its synthesis route is as follows.

To a suspension of compound 5.3 (320 g, 1.53 mol) and K2CO3 (276 g, 2 mol) in EtOAC (3 L) was added MeI (238.9 g, 1.68 mol) below 20 C. The mixture was stirred at room temperature for 12 hours. TLC (EtOAc/petroleum ether=1:3) indicated the reaction was complete. Water (2 L) was added to the mixture. The organic phase was separated, dried over Na2SO4 and concentrated to give 5.4 (320 g, 93.8%) as a pink solid.

72752-81-9, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,72752-81-9 ,Methyl 2-mercaptobenzo[d]oxazole-6-carboxylate, other downstream synthetic routes, hurry up and to see

Reference：
Patent; TIBOTEC BVBA; US2010/305073; (2010); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

151230-42-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6-Bromo-2-methylbenzo[d]oxazole, cas is 151230-42-1,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1.0 mmol of 6-bromo-2-methyl-benzooxazole [151230-42-1], 2 mmol of acrylonitrile, 1.0 mmol of sodium acetate, 0.1 mmol of Pd(OAc)2 and 0.2 mmol of P(o-tolyl)3 in 3 ml of DMF under N2 atmosphere is treated at 1500C for 1 h in the microwave. The reaction is filtered through a short plug of Hyflow. The solvent of the filtarate is concentrated by evaporation. The title compound is obtained from the residue by chromatography on Varian Mega Bond Elut (Si) eluting with EtOAc to a mixture of petroleum ether/EtOAc 10:1 to afford the title compound as a mixture of cis and trans geometric isomers. Rf = 0.15 (CH2CI2-MeOH 100:2); Rt = 4.48.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6-Bromo-2-methylbenzo[d]oxazole, 151230-42-1

Reference：
Patent; NOVARTIS AG; WO2009/135526; (2009); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is 6-Bromo-2-methylbenzo[d]oxazole, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 151230-42-1, its synthesis route is as follows.

[0510] Compound 71a: To a mixture of Comp-8b (0.47 g, 2.35 mmol) and 6-bromo-2- methylbenzo[d]oxazole (0.5 g, 2.35 mmol) in was added 7-BuOK (2 mL, IM in THF) at 0 C and the reaction mixture was stirred at RT for 12 h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was concentrated under reduced pressure and the crude obtained was purified by column chromatography (silica, 230-400 mesh, 40-50% EtOAc in hexane) to afford (E)-6-bromo-2-(2-(2,5-dimethyl-l-phenyl-lH- pyrrol-3-yl)vinyl)benzo|i ]oxazole (71a; 0.3 g, 32%) as a yellow solid.

151230-42-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,151230-42-1 ,6-Bromo-2-methylbenzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference：
Patent; ALPINE ANDROSCIENCES, INC.; PATIL, Santhosh N.; SARMA, Bugga VNBS; (148 pag.)WO2019/152731; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

3889-13-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, cas is 3889-13-2,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The resulting benzoxazolone (1 equiv.), 2-dibromobutane (1.5 equiv) and potassium carbonate (1.5 equiv.) were suspended in anhydrous DMF and stirred at ambient temperature and under a nitrogen atmosphere for 8 h. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel chromatograph. See title compounds for characterisation.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, 3889-13-2

Reference：
Article; Tieu, William; Jarrad, Angie M.; Paparella, Ashleigh S.; Keeling, Kelly A.; Soares Da Costa, Tatiana P.; Wallace, John C.; Booker, Grant W.; Polyak, Steven W.; Abell, Andrew D.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 19; (2014); p. 4689 – 4693;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, and cas is 3889-13-2, its synthesis route is as follows.

A solution of 5-nitro-3H-benzooxazol-2-one (26 g) in DMF (100 mL) was added to a suspension of NaH (60% in mineral oil, 10.71 g) in DMF (100 mL) over a period of 1 hour. Stirring was continued for 45 minutes at r.t. The mixture was cooled to 0 C. and methyl iodide dissolved in DMF (20 mL) was added dropwise over a period of 30 minutes. The mixture was stirred over night at r.t. The reaction mixture was poured into ice/water and extracted two times with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, filtered and the solvent was evaporated. CH2Cl2_methanol=4:1 (150 mL) was added to the resulting precipitate and the suspension was stirred for 1 hour at r.t. The solid was filtered off and dried in vacuo. The title compound was obtained as a orange solid (18.33 g, 62%). MS (EI)=194.0 [M+].

3889-13-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,3889-13-2 ,5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, other downstream synthetic routes, hurry up and to see

Reference：
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249124; (2010); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem