Month: April 2022

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of organic γ-oxides by catalytic hydrogenation of the furan nucleus, published in 1938, which mentions a compound: 3194-15-8, mainly applied to , Product Details of 3194-15-8.

cf. preceding abstract α-Propionylfuran (I) was prepared in 37.6% yield by condensation of EtCOCl and furan with excess AlCl3 in CS2. I, m. 28.5-9.5°, b20 86.2°; semicarbazone, m. 177-8°. A mixture of 45 g. I in 80 ml. of absolute alc. with 24 g. of 90% H2NNH2.H2O in 40 ml. alc. was refluxed on a water bath for 4 hrs. and the alc. was distilled off. The hydrazone was decomposed by heating it with 1.5 g. of powd. KOH and a little platinized kaolin, giving 43.5% α-propylfuran, b750 114.5-15.5°, d420 0.8905, nD20 1.4459, M. R. 32.96. Passing it with H over Pd deposited on asbestos at 150° gave α-propyltetrahydrofuran, b756 132-3°, d420 0.8548, nD20 1.4242, M. R. 34.08. AcCl and α-methylfuran with AlCl3 in CS2 gave 28.3% α-methyl-α’-acetylfuran, b7 69-70°, d419 1.0574, nD19 1.5123; semicarbazone, m. 171°. Its hydrazone when decomposed with KOH and Pt formed 59.6% α-methyl-α’-ethylfuran, b742 116-18°, d420 0.8883, nD20 1.4473, M. R. 33.13. Hydrogenated as above, it gave α-methyl-α’-ethyltetrahydrofuran, b756 118-19°, d420 0.8326, nD20 1.4144, M. R. 34.28. The activity of the Pd catalyst is increased by the presence of KOH impurities.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

COA of Formula: C9H9NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Ethylbenzo[d]oxazole, is researched, Molecular C9H9NO, CAS is 6797-13-3, about Addition of 2-ethylbenzazoles to aromatic aldehydes in the presence of aqueous sodium hydroxide. Author is Dryanska, V.; Ivanov, K.; Nikolov, M..

Treating benzazoles I with R1CHO (R1 = Ph, 2-ClC6H4, 4-ClC6H4, 2-MeC6H4, 4-MeC6H4, 4-MeOC6H4) gave II and III, whereas R1CHO (R1 = 2-BrC6H4, 2,4-(MeO)2C6H3, 1-naphthyl, 4-Me2NC6H4) gave only III. IV were similarly obtained from 2-benzylbenzoxazole.

Compound(6797-13-3)COA of Formula: C9H9NO received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Ethylbenzo[d]oxazole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Stereochemical Studies of Ag-Catalyzed Hosomi-Sakurai Reaction Using Chiral Silanes, the main research direction is stereochem silver catalyzed Hosomi Sakurai chiral silane.Computed Properties of C38H24F4O4P2.

Stereochem. aspect of asym. Ag-catalyzed Hosomi-Sakurai reaction with ketones was studied. Several allyltrimethoxysilanes were synthesized and used for the asym. reaction. Remarkably, among several possible diastereomers only two are generated with high levels of diastereo- and enantioselectivities. Based on the observations for different allyltrimethoxysilanes, the authors hypothesize formation of a single allylsilver species which undergoes addition to the ketone.(© KGaA, 69451 Weinheim, Germany, 2009). Wiley-VCH Verlag GmbH and Co.

Compound(503538-69-0)Computed Properties of C38H24F4O4P2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 33941-15-0, is researched, Molecular C12H25NO5, about The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors, the main research direction is equilibrium SARS CoV2 protease small mol inhibitor.Recommanded Product: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane.

Abstract: The maturation of coronavirus SARS-CoV-2, which is the etiol. agent at the origin of the COVID-19 pandemic, requires a main protease Mpro to cleave the virus-encoded polyproteins. Despite a wealth of exptl. information already available, there is wide disagreement about the Mpro monomer-dimer equilibrium dissociation constant Since the functional unit of Mpro is a homodimer, the detailed knowledge of the thermodn. of this equilibrium is a key piece of information for possible therapeutic intervention, with small mols. interfering with dimerization being potential broad-spectrum antiviral drug leads. In the present study, we exploit Small Angle X-ray Scattering (SAXS) to investigate the structural features of SARS-CoV-2 Mpro in solution as a function of protein concentration and temperature A detailed thermodn. picture of the monomer-dimer equilibrium is derived, together with the temperature-dependent value of the dissociation constant SAXS is also used to study how the Mpro dissociation process is affected by small inhibitors selected by virtual screening. We find that these inhibitors affect dimerization and enzymic activity to a different extent and sometimes in an opposite way, likely due to the different mol. mechanisms underlying the two processes. The Mpro residues that emerge as key to optimize both dissociation and enzymic activity inhibition are discussed.

Compound(33941-15-0)Recommanded Product: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1,4,7,10,13-Pentaoxa-16-azacyclooctadecane), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Computed Properties of C8H8N2S. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Toxicity Study of a Rubber Antioxidant, Mixture of 2-Mercaptomethylbenzimidazoles, by Repeated Oral Administration to Rats. Author is Saitoh, M.; Umemura, T.; Kawasaki, Y.; Momma, J.; Matsushima, Y.; Sakemi, K.; Isama, K.; Kitajima, S.; Ogawa, Y.; Hasegawa, R.; Suzuki, T.; Hayashi, M.; Inoue, T.; Ohno, Y.; Sofuni, T.; Kurokawa, Y.; Tsuda, M..

2-Mercaptobenzimidazole (2-MBI), a rubber antioxidant, is known to exhibit potent antithyroid toxicity in rats and is a candidate as an environmental endocrine disrupter. 2-Mercaptomethylbenzimidazoles (a 1:1 mixture of 4-Me and 5-Me isomers, MMBIs), are also employed industrially as rubber antioxidants and are suspected to exert antithyroid toxicity such as 2-MBI. In this investigation, acute and subacute oral toxicity studies of MMBIs in Wistar rats were conducted. The clin. signs of acute oral toxicity were observed including decreased spontaneous movement, a paralytic gait, salivation and lacrimation, and adoption of prone and lateral positions. The LD50 was estimated to be 330 mg/kg. In the subacute oral toxicity study, male and female rats were treated with MMBIs by gavage at doses of 0 (corn oil), 4, 20 and 100 mg/kg for 28 consecutive days followed by a 2-wk recovery period for the control and highest dose groups. Body weight and food consumption, clin. signs, organ weights, clin. biochem. and hematol. parameters including clotting times and micronuclei induction in bone marrow erythropoietic cells, and histopathol. were examined Relative organ weights of lung, liver and kidney, and serum cholesterol and phospholipid significantly increased in male rats treated with MMBIs at doses of 20 and 100 mg/kg. Male rats administered 100 mg/kg MMBIs exhibited a 1.8-fold increase in thyroid weight associated with histopathol. changes but not altered serum thyroid hormone levels. Female rats administered 100 mg MMBIs/kg exhibited significant increases of liver and kidney but not thyroid weights, and serum cholesterol level. The antithyroid toxicity of MMBIs in rats was estimated to be one-tenth that of 2-MBI. No-observed-effect levels for male and female rats were found to be 4 and 20 mg/kg, resp., in this subacute oral toxicity study.

Compound(27231-36-3)Computed Properties of C8H8N2S received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Mercapto-5-methylbenzimidazole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Robinson, Anthony L.; Boss, Paul K.; Heymann, Hildegarde; Solomon, Peter S.; Trengove, Robert D. researched the compound: 1-(Furan-2-yl)propan-1-one( cas:3194-15-8 ).Application of 3194-15-8.They published the article 《Development of a sensitive non-targeted method for characterizing the wine volatile profile using headspace solid-phase microextraction comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry》 about this compound( cas:3194-15-8 ) in Journal of Chromatography A. Keywords: wine flavor headspace solid microextraction GC MS. We’ll tell you more about this compound (cas:3194-15-8).

Future understanding of differences in the composition and sensory attributes of wines require improved anal. methods which allow the monitoring of a large number of volatiles including those present at low concentrations This study presents the optimization and application of a headspace solid-phase microextraction (HS-SPME) method for anal. of wine volatiles by comprehensive two-dimensional gas chromatog. (GC × GC) time-of-flight mass spectrometry (TOFMS). This study demonstrates an important advancement in wine volatile anal. as the method allows for the simultaneous anal. of a significantly larger number of compounds found in the wine headspace compared to other current single dimensional GC-MS methodologies. The methodol. allowed for the simultaneous anal. of over 350 different tentatively identified volatile and semi-volatile compounds found in the wine headspace. These included potent aroma compound classes such as monoterpenes, norisoprenoids, sesquiterpenes, and alkyl-methoxypyrazines which have been documented to contribute to wine aroma. It is intended that wine aroma research and wine sensory research will utilize this non-targeted method to assess compositional differences in the wine volatile profile.

Compound(3194-15-8)Application of 3194-15-8 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Furan-2-yl)propan-1-one), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

COA of Formula: C38H24F4O4P2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Pd/Zn Co-catalyzed Asymmetric Ring-opening Reactions of Aza/Oxabicyclic Alkenes with Oximes. Author is Shen, Guoli; Khan, Ruhima; Yang, Fan; Yang, Yong; Pu, Dongdong; Gao, Yang; Zhan, Yong; Luo, Yang; Fan, Baomin.

An application of various oximes as nucleophiles in the asym. ring-opening (ARO) reaction of aza/oxabicyclic alkenes resulting in cis-ARO products has been developed. The reaction was co-catalyzed by Pd(OAc)2 and Zn(OTf)2 with (R)-DIFLUORPHOS as the chiral ligand. This methodol. exhibits broad substrate scope, functional group tolerance with high enantioselectivity. A synthetic application of this method has been demonstrated.

Compound(503538-69-0)COA of Formula: C38H24F4O4P2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Furan-2-yl)propan-1-one( cas:3194-15-8 ) is researched.Category: benzoxazole.Paravisini, Laurianne; Prot, Aurelie; Gouttefangeas, Cecile; Moretton, Cedric; Nigay, Henri; Dacremont, Catherine; Guichard, Elisabeth published the article 《Characterisation of the volatile fraction of aromatic caramel using heart-cutting multidimensional gas chromatography》 about this compound( cas:3194-15-8 ) in Food Chemistry. Keywords: caramel cooking aroma volatile furan lactone acid; Caramel; Heart-cutting multidimensional gas chromatography (MDGC); Mass Spectrometry; Odorant compounds; Olfactometry. Let’s learn more about this compound (cas:3194-15-8).

The first aim of the study was to improve characterization of the volatile fraction of aromatic caramel by applying heart-cutting multidimensional gas chromatog. coupled to mass spectrometry and olfactometry (MDGC-MS-O) on targeted odorant fractions. The second aim was to compare the volatile composition of two caramel samples, which differed in terms of their carbohydrate composition and cooking process. MDGC analyses enabled identification of 37 compounds (17 with the addition of pure standard) in the burnt sugar caramel, 20 of which were reported for the first time in caramel. Fifteen compounds were identified as odor-active and described using a range of attributes such as floral, roasted, spicy and almond. Furans, lactones and acids resulting from the thermal breakdown of sugars predominated in the volatile fraction of the burnt sugar caramel, due to the harsher cooking conditions. These results have enabled a clearer understanding of aromatic caramel as well as the identification of new compounds which might make an important contribution to its aroma.

Compound(3194-15-8)Category: benzoxazole received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Furan-2-yl)propan-1-one), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthetic Route of C9H9NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Ethylbenzo[d]oxazole, is researched, Molecular C9H9NO, CAS is 6797-13-3, about Ag@TiO2 nanocomposite; synthesis, characterization and its application as a novel and recyclable catalyst for the one-pot synthesis of benzoxazole derivatives in aqueous media. Author is Maleki, Behrooz; Baghayeri, Mehdi; Vahdat, Seyed Mohammad; Mohammadzadeh, Abbas; Akhoondi, Somaieh.

A series of benzoxazole derivatives I (R = H, 3-NO2C6H4, CH2CH3, 3-CH3OC6H4, etc.) were synthesized via Ag@TiO2 nanocomposite catalyzed one-pot condensation of 2-aminophenol and several aromatic aldehydes or orthoesters or carboxylic acids or amides or acyl chlorides in water at room temperature with excellent yields. The short reaction times, high yields, safety and mild conditions, simplicity, non-toxicity and easy workup were the main merits of this protocol.

Compound(6797-13-3)Synthetic Route of C9H9NO received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Ethylbenzo[d]oxazole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Category: benzoxazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about 1,4-Addition in the furan series. I. Condensation of benzylmagnesium bromide with α-furyl ketones. Author is Berreby, Edgar; Morizur, Jean P.; Wiemann, Joseph.

A mixture of 27.5 g. 2-acetylfuran in 50 cc. ether was refluxed 1 hr. with PhCH2MgBr prepared from 42.75 g. PhCH2Br and hydrolyzed with HCl to give 10 g. of the starting material and 34 g. of a mixture, b0.01 82-92°. This mixture was redistilled to give 18% dibenzyl, b5 115-17°, 20% 1-phenyl-2-furyl-2-propanol, b5 123°, and 30% 2-acetyl-3-benzyl-2,3-dihydrofuran, b7 131°. Similar treatment of ethyl 2-furyl ketone gave 31.5 g. of a mixture containing 11% dibenzyl, 24% 1-phenyl-2-furyl-2-butanol, b6 136°, and 24% 2-propionyl-3-benzyl-2,3-dihydrofuran, b6 131°. N.M.R. and ir data are given.

Compound(3194-15-8)Category: benzoxazole received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Furan-2-yl)propan-1-one), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem