Month: April 2022

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 503538-69-0, is researched, SMILESS is FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1, Molecular C38H24F4O4P2Journal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Access to enantioenriched α-amino esters via rhodium-catalyzed 1,4-addition/enantioselective protonation, Author is Navarre, Laure; Martinez, Remi; Genet, Jean-Pierre; Darses, Sylvain, the main research direction is amino acid ester asym preparation; aryltrifluoroborate amino acrylate conjugate addition protonation rhodium.Recommanded Product: 503538-69-0.

Conjugate addition of potassium trifluoro(organo)borates to dehydroalanine derivatives, mediated by a chiral rhodium catalyst and in situ enantioselective protonation, afforded straightforward access to a variety of protected α-amino esters with high yields and enantiomeric excesses up to 95%. Among the tested chiral ligands and proton sources, Binap, in combination with guaiacol (2-methoxyphenol), an inexpensive and nontoxic phenol, afforded the highest asym. inductions. Organostannanes have also shown to participate in this reaction. By a fine-tuning of the ester moiety, and using Difluorophos as chiral ligand, increased levels of enantioselectivity, generally close to 95%, were achieved. Deuterium labeling experiments revealed, and DFT calculation supported, an unusual mechanism involving a hydride transfer from the amido substituent to the α carbon explaining the high levels of enantioselectivity attained in controlling this α chiral center.

Compound(503538-69-0)Recommanded Product: 503538-69-0 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Reduction of α-furyl ketones by chemical methods at different potentials. Properties and physical-chemical studies of the different compounds obtained》. Authors are Morizur, Jean Pierre; Wiemann, Joseph.The article about the compound:1-(Furan-2-yl)propan-1-onecas:3194-15-8,SMILESS:O=C(C1=CC=CO1)CC).Electric Literature of C7H8O2. Through the article, more information about this compound (cas:3194-15-8) is conveyed.

α-Furyl alkyl ketones were reduced by Zn (E0  0.75 v.) in AcOH, Mg (E0 = 2.5 v.) in AcOH, and Na amalgam (E0 = 2.7 v.) in H2O. The products were characterized by infrared (IR) and nuclear magnetic resonance (NMR) spectra. The following ketones were prepared by known methods [alkyl group and b.p. (mm.) given]: Me (I), 69° (15); Et (II), 74-6° (11); Pr (III), 96° (20). To a stirred suspension of 50 g. Zn in 500 ml. H2O at 50° was added over 3 hrs. 1 mole ketone in 100 g. AcOH simultaneously with 50 g. Zn and the mixture stirred 1 hr. to give the following results. I gave 2.5 g. IV, b0.05 80-2°, m. 121-2° (benzene), and 27.5 g. 2,3-di-2-furylbutane-2,3-diol (V), b0.05 92-4°. II and III gave, resp., 25 g. 3,4-di-2-furylhexane-3,4-diol (VI), b0.05 96-8°, and 28 g. 4,5-di-2-furyloctane-4,5-diol (VII), b0.05 104-6°. To a stirred mixture of 1 mole ketone in 500 ml. H2O at 100°, 72 g. Mg was added in small portions with dropwise addition of 400 g. 90% AcOH over 6 hrs. to give (from I) 5 g. IV, 27 g. V, and 32 g. VIII (R = Me), b0.05 102-5°, (from II) 30 g. VI, 36 g. VIII (R = Et), b0.05 106-9°, and (from III) 15 g. VII, 18 g. VIII (R = Pr), b0.05 111-13°. One mole I was reduced at -35° by 34.5 g. Na as an amalgam ( CA 55, 363d) to give 8 g. IV, 7 g. V, m. 47-8°, and 3 g. VIII (R  Me). Hydrogenation of IV by LiAlH4 in ice-cold Et2O gave IX, m. 98-100° (benzene). Similar treatment of the γ-ketols gave dihydroxy compounds melting over a 30-40° range.

Compound(3194-15-8)Electric Literature of C7H8O2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Furan-2-yl)propan-1-one), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Saha, Prasenjit; Ramana, Tamminana; Purkait, Nibadita; Ali, Ashif Md; Paul, Rajesh; Punniyamurthy, Tharmalingam published the article 《Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles》. Keywords: benzimidazole aminobenzimidazole aminobenzothiazole benzoxazole preparation; intramol cyclization bromoaryl derivative copper oxide nanoparticle catalyst.They researched the compound: 2-Ethylbenzo[d]oxazole( cas:6797-13-3 ).Product Details of 6797-13-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:6797-13-3) here.

The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramol. cyclization of o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. E.g., cyclization of o-bromoaryl amidine I gave 95% benzimidazoles II. The procedure is exptl. simple, general, efficient, and free from addition of external chelating ligands. It is a heterogeneous process and the copper(II) oxide nanoparticles can be recovered and recycled without loss of activity.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chain-substituted methinecyanines and styryl dyes, published in 1956, which mentions a compound: 6797-13-3, mainly applied to , Formula: C9H9NO.

Various methinecyanines carrying a substituent on the chain have been prepared and their absorption maximum compared with those of the parent dyes. The procedure of Schott [Ber. 29, 1985(1896)] in which PhCH2CO2H (I) and PCl5 were reported to give PhCH2COCl (II) could not be reproduced. Instead, to 18 cc. boiling SOCl2 was added in 10 min. 27.2 g. I, the whole refluxed 0.5 hr. and distilled to give 77% II, b17 96-8°. To 17.8 g. II and 1 equivalent o-HSC6H4NH2.HCl was added 0.33 mole P2O5, the whole heated 8 min. in an oil bath at 160-175°, warmed with aqueous NaOH, the whole cooled, extracted with Et2O, and the Et2O extracts concentrated and distilled to give 29% 2-benzylbenzothiazole (III), b0.5 157-63°. III (9.82 g.) and 1.2 equivalents EtI heated 48 hrs. at 100° and the mixture treated with Me2CO gave 57% of the ethiodide (IV), yellow crystals, m. 181° (from EtOH). In similar fashion, were prepared 73% 2-(p-nitrobenzyl)benzothiazole, m. 115° (from EtOH) [ethiodide (V), m. 249° (decomposition)(from MeOH)] and 18% 2-(chloromethyl)benzothiazole (VA), b0.2 79-91°, m. 34° (from petr. ether); VA and EtI gave no ethiodide. To 20.85 g. Zn salt of o-H2NC6H4SH in 90 cc. boiling dry C6H6 was added gradually 1 equivalent EtO2CCOCl (VI) (b21 75-8°) in 120 cc. dry C6H6, the whole refluxed 6 hrs., filtered, the insoluble residue extracted with boiling C6H6, the C6H6 filtrates and extracts combined, washed with excess aqueous NaHCO3, washed with H2O, dried, and distilled to give 2-ethoxycarbonylmethylbenzothiazole (VIA), yellow liquid, b0.5 121-26° [methiodide (VII), m. 175° (decomposition) (from MeOH-Me2CO); ethiodide (VIII), m. 190° (decomposition) (from EtOH)]. To 0.81 g. o-HSC6H4NHEt (IX) in 4 cc. dry C6H6 was added 1.1 equivalent VI in 2 cc. dry C6H6, the whole cooled to room temperature, the liquid decanted, the gum washed with C6H6, the C6H6-insoluble residue dissolved in 2 cc. MeOH, and the MeOH solution treated with a warm solution of 2 equivalent KI in 4 cc. H2O to give VIII. By the same procedure, IX and ClCH2COCl in C6H6, followed by KI gave 13-19% 2-(o-ethylaminophenylthiomethyl)benzothiazole ethiodide (IXA), m. 158° (decomposition) (from MeOH). 2-Ethylthiobenzothiazole (X) 19.93 g. and 1 equivalent neutral Et2SO4 heated 8 hrs. at 110-20°, the whole dissolved in 120 cc. H2O, the solution extracted with Et2O, the aqueous solution separated, cooled, and treated with an excess of NaOH gave 30-83% 3-ethyl-2-oxobenzothiazoline (XI), colorless liquid, b0.5 101° (a contaminant which was difficult to sep. from XI was 3-ethyl-2-thiobenzothiazoline (XII)). X (19.5 g.) and 1 equivalent Et2SO4 heated 8 hrs. at 110-20°, the whole dissolved in 100 cc. C5H5N, and the solution refluxed 1 hr. and poured into warm H2O gave 82% XII, m. 77-8° (from MeOH). Freshly prepared 2-ethylthiobenzothiazole.EtI (XIII) 0.63 g. and 3 cc. C5H5N refluxed 10 min. and the whole poured into 12 cc. H2O gave 68% XII. On standing for several months, XIII was gradually converted to XII. Distilled XI (12.1 g.) in 24 cc. EtOH and 6 equivalents KOH in 70 cc. EtOH refluxed 1 hr., cooled, the K2CO3 filtered, the filtrate evaporated to dryness, the residue dissolved in 100 cc. H2O, the H2O solution cooled and made acidic with concentrated HCl, the oily product extracted with C6H6, and the C6H6 solution dried, concentrated, and distilled gave 77% IX, b0.5 57-60°. XII (19.53 g.) in 40 cc. EtOH and 6 equivalents KOH in 105 cc. EtOH refluxed 6 hrs. and treated as above gave 70% IX. o-H2NC6H4OH (XIV) 42.6 g. was added slowly to 3 equivalents (EtCO)2O, the whole was heated 0.5 hr. on a H2O bath, then distilled from an oil bath, rejecting material b. below 150°. The residual material was washed thoroughly with 10% Na2CO3 solution, separated, and distilled to give 28% 2-ethylbenzoxazole (XIVA), b0.3-0.5 40-3°; ethiodide (XV), colorless crystals, m. 198° (decomposition) (from EtOH). XIV (10.9 g.) and 1 equivalent PhCH2CO2H heated 3 hrs. at 200-25° (H2O vapor allowed to distil), the mixture cooled, treated with aqueous NaOH, extracted with C6H6, and the C6H6 solution concentrated and distilled gave 48% 2-benzylbenzoxazole (XVA), b0.3 118-25°; no ethiodide could be prepared and the Et p-toluene-sulfonate (XVI) was a gum which could be dissolved in EtOH and used in the dye condensations described below. To 1 mole 2-ethylbenzothiazole-EtI (XVII) and 1 mole 2-iodoquinoline-EtI (XVIII) in EtOH there was added 2.1 moles Et3N. The mixture stirred and refluxed 1-30 min., the whole cooled, treated with Et2O, the precipitated gum separated, and washed with Et2O gave 54-84% [2-(3-ethylbenzothiazole)][2-(1-ethylquinoline)]methylmethinecyanine iodide (XIX), olive-green dye, softens 125°, m. about 148° (from Me2CO and from EtOH). XIX was homogeneous as shown by a chromatogram from CHCl3 on alumina. XIX had a slight desensitizing action toward a photographic emulsion. In a similar experiment with 2-ethylbenzothiazole-p-MeC6H4SO3Et (XIXA), the gum precipitated with Et2O and heated with aqueous KI gave 66% XIX. XVII (0.8 g.) and 2-ethylthioquinoline reacted as above gave a mixture of 12% XIX and a trace of [2-(3-ethylbenzothiazole)][2-(1-ethylquinoline)]methinecyanine iodide, separated by absorption on alumina and elution with CHCl3-EtOH. In a similar fashion, XVII and XIII gave 8% bis[2-(3-ethylbenzothiazole)]methylmethinecyanine iodide, brick-red crystals, m. about 214° and a trace of the bis[2-(3-ethylbenzothiazole)][2-(1-ethylquinoline)]phenylmethinecyanine iodide (from EtOH); 2-methylbenzothiazole-EtI and 2-iodo-5,6-benzoquinoline-EtI (XX) gave 42% [2-(1-ethyl-5,6-benzoquinoline)][2-(3-ethylbenzothiazole)]methinecyanine iodide, red-orange crystals, m. 258° (decomposition) (from MeOH); XVII and XX gave 67% [2-(1-ethyl-5,6-benzoquinoline)][2-(3-ethylbenzothiazole)]methylmethinecyanine iodide, dark-purple crystals, m. about 225° (violent decomposition) (from EtOH); XIII and XX gave 42% [2-(1-ethyl-5,6-benzoquinoline)][2-(3-ethylbenzothiazole)]phenylmethinecyanine iodide, purple crystals, m. about 175° (decomposition) (from EtOH); XVII and 1-iodoisoquinoline-EtI (XXI) gave the dye iodide, which in hot EtOH with hot aqueous NaClO4 gave 72% [2-(3-ethylbenzothiazole)][1-(2-ethylisoquinoline)]-methylmethinecyanine perchlorate, vermillion crystals, m. about 164° (decomposition) (from EtOH); III and XXI gave 36% [2-(3-ethylbenzothiazole)][1-(2-ethylisoquinoline)]phenylmethinecyanine iodide, maroon crystals, m. 227° (decomposition) (from EtOH); and XIXA and 4-iodoquinoline.EtI (XXII) (the reaction mixture after 2-min. reflux was treated with aqueous KI) gave 49% [2-(3-ethylbenzothiazole)][4-(1-ethylquinoline)]methylmethinecyanine iodide (XXIII), olive-green crystals, m. 185° (decomposition) (from EtOH). XVII 1 mole, 3 moles quinoline-EtI, 3 moles KOH, and EtOH refluxed 0.5 hr., the solid (XXIV) filtered, the XXIV (apocyanines) boiled with 25 cc. EtOH, the solid (XXV) filtered, washed with 5 cc. hot EtOH, the combined filtrate and washings cooled gave 8% erythroapocyanine (XXVI); the XXV represented 0.5% xanthoapocyanine (XXVII) (see below); quinoline-EtI in boiling MeOH-KOH gave 31% XXIV; the XXIV extracted with boiling EtOH left 0.5% XXVII [[2-(1-ethylquinoline)][3-(1-ethylquinoline)]cyanine iodide]; the EtOH extracts were concentrated to give 14% XXVI [[3-(1-ethylquinoline)][4-(1-ethylquinoline)]cyanine iodide], m. 215-20° (decomposition) (from EtOH), λmaximum 5160 A. (ε 31,600) (in MeOH). Quinoline-EtI (7 g.) in 140 cc. EtOH and 2.76 g. Na in 20 cc. EtOH refluxed 1 hr. and the solid filtered gave 5% XXVII, orange crystals, m. >305° (from MeOH), λmaximum 4610 A., 3620 A. (ε 19,900, 6200). To IV and XXII in EtOH was added 180-mesh anhydrous K2CO3 and the whole refluxed 2 min. to give 56% [2-(3-ethylbenzothiazole)] [4-(1-ethylquinoline)] phenylmethinecyanine iodide, m. about 222° (decomposition) (from EtOH and from MeOH). V and p-MeC6H4SO3Et heated 4 hrs. at 165-75°, the product dissolved in hot EtOH, and then treated with XVIII gave the crude iodide (XXVIII) as a gum; XXVIII in CHCl3 chromatographed on alumina and eluted with CHCl3-EtOH (99:1)gave 6% [2-(3-ethylbenzothiazole)] [2-(1-ethylquinoline)]-p-nitrophenylmethinecyanine iodide, dark-purple crystals, m. 216° (decomposition) (from EtOH). 2-Ethylthioquinoline and Et2SO4 heated 8 hrs. at 110-20°, the salt in hot EtOH, VIA, and Et3N refluxed-5 min., the whole acidified with HCl, treated with NaClO4 in hot H2O, the whole cooled, the orange tar freed of liquid, washed well with hot H2O, and while wet dissolved in hot MeOH gave 66% perchlorate salt (XXIX), red crystals, m. 195° (decomposition). XXIX triturated with aqueous NaOH, the whole extracted with C6H6, the C6H6 extracts dried and concentrated, the residue dissolved in hot C6H6, the solution filtered, and the filtrate diluted with pert. ether gave 51% ethoxycarbonylmethine[2-benzothiazole] [2-(1-ethyldihydroquinoline)] (XXX), black crystals, m. 179° (decomposition), λmaximum 5170 A. (ε 13,500) (in MeOH containing NH3), λmaximum 3290 A., 4780 A. (ε 41,500, 8100) (in MeOH containing H2SO4). Similarly, X (0.98 g.) and Et2SO4 heated 8 hrs. at 110-20° and the salt (XXXI) reacted with VIA as above gave 79% perchlorate, m. 137° (decomposition) (from MeOH), which yielded 65% ethoxycarbonylmethine[2-benzothiazole][2-(3-ethyl-2,3-dihydrobenzothiazole)] (XXXII), pale-yellow crystals, m. 127° (from C6H6-petr. ether), λmaximum 3430 A. (ε 17,500) (in MeOH containing NH3), λmaximum 4230 A. (ε 9110) (in MeOH containing H2SO4). XXX and MeI heated 24 hrs. at 100°, the product washed first with hot C6H6 and then with aqueous NaHCO3, gave 25% [2-(1-ethylquinoline)] [2-(3-methyl-benzothiazole)]ethoxycarbonylmethinecyanine iodide, red crystals, m. 206° (decomposition). XXX and EtI similarly gave 32% [2-(3-ethylbenzothiazole)][2-(1-ethylquinoline)]-ethoxycarbonylmethinecyanine iodide, orange crystals, m. 190° (decomposition) (from aqueous MeOH). XXXI, as above, and 2-methylbenzothiazole-p-MeC6H4SO3Me gave 41% [2-(3-ethylbenzothiazole)] [2-(3-methylbenzothiazole)]methinecyanine iodide, pale-yellow crystals, m. 287° (decomposition) (from EtOH). XXXII and MeI gave 25% [2-(3-ethylbenzothiazole)] [2-(3-methylbenzothiazole)]ethoxycarbonylmethinecyanine, pale-yellow crystals, m. 224° (decomposition) (from MeOH); while XXXII and EtI gave 45% [bis-2-(3-ethylbenzothiazole)]ethoxycarbonylmethinecyanine iodide, yellow crystals, m. 218° (decomposition) (from MeOH). Dibenzothiazolylmethane-EtI (XXXIIA), XVIII, Et3N, and EtOH gave 20% [2-(3-ethylbenzothiazole)][2-(1-ethylquinoline)](2-benzothiazolyl)methinecyanine iodide, purple crystals, m. 232°. 2-Methylbenzoxazole-EtI (XXXIII) and XVIII gave 15% [2-(3-ethylbenzoxazole)][2-(1-ethylquinoline)]methinecyanine iodide, yellow crystals, m. 277° (decomposition) (from EtOH). XV and XVIII gave an unstable iodide dye, maroon crystals, m. 133° (decomposition) (from EtOH). XVI and XVIII similarly gave 26% [2-(3-ethylbenzoxazole)] [2-(1-ethylquinoline)]phenylmethinecyanine iodide, maroon crystals, m. 227° (decomposition) (from EtOH). 2-Ethylthiobenzoxazole, 2-methyl-5,6-benzoquinoline, and p-MeC6H4SO3Et heated 3.5 hrs. at 150-60°, the gum dissolved in 15 cc. hot EtOH and treated with aqueous KI gave 17% [2-(1-ethyl-5,6-benzoquinoline)] [2-(3-ethylbenzoxazole)]-methinecyanine iodide (XXXIV), m. 275° (decomposition) (from MeOH), λmaximum 4630, 4450 A. (ε 50,300, 49,400); alternatively, XX and XXXIII gave 3% XXXIV along with bis-2-(1-ethyl-5,6-benzoquinoline)methinecyanine iodide, m. 310° (decomposition). XVI and XX gave 2% [2-(1-ethyl-5,6-benzoquinoline)] [2-(3-ethylbenzoxazole)]phenylmethinecyanine iodide, red crystals, m. 183° (decomposition); XXI and 2-methylbenzoxazole-p-MeC6H4SO3Et gave 37% [2-(3-ethylbenzoxazole)][1-(2-ethylisoquinoline) ]methinecyanine iodide, red crystals, m. 228° (decomposition) (from EtOH). XVA by similar reactions (a) with XXI gave 27% of the corresponding phenylcyanine iodide, vermilion crystals, m. about 180° (decomposition) (from EtOH) and (b) with XXII 4% [2-(3-ethylbenzoxazole)] [4-(1-ethylquinoline)]phenylmethinecyanine iodide, maroon crystals, m. 224° (decomposition) (from Me2CO and from EtOH). The following compounds are derivatives of XXXV and XXXVI. 2-Methylbenzothiazole-EtI, p-Et2NC6H4CHO (XXXVII), and Ac2O were refluxed 20 min., the whole poured into a hot solution of KI in H2O, and the solid filtered and washed with Et2O to give 62% XXXV (R = H, R’ = Et) (XXXVIII), indigo-blue crystals, m. 225° (decomposition) (from MeOH). Similarly, XVII and XXXVII gave 57% XXXV (R = R’ = Me) (XXXIX), dark-blue crystals, m. 197° (decomposition) (from EtOH). The Et2O washings were evaporated, the residue dissolved in hot C6H6, and the C6H6 solution diluted with an equal volume of petr. ether to give 6% 3-ethyl-2-[2-(4-iminocyclohexa-2,5-dienylidene)-l-methylethylidene] benzothiazoline (XL), yellow crystals, m. 160°, λmaximum 3840 A. (ε 15,400). 2-Ethylbenzothiazole-EtI and XXXVII gave 18% XXXV (R = Me, R’ = Et), red crystals, m. 192° (decomposition), a trace of XXXVIII and, as above, the ethylimino analog of XL, m. 137° (from EtOH), λmaximum 3930 A. (ε 13,600). IV and Me2NC5H4CHO (XLI) gave 63% XXXV (R = Ph, R’ = Me), red crystals, m. about 180° (decomposition) (from AcOH). V and XLI gave 26% XXV (R = p-O2NC6H4, R’ = Et), terra cotta crystals, m. 203° (decomposition)(from MeOH) and the 1-(p-nitrophenyl)ethylidene analog of XL, yellow crystals, m. 220° (from Ac2O). VIII and XLI gave 24% XXXV (R = EtO2C, R’ = Me), orange crystals, m. 199° (decomposition) (from EtOH). XXXIIA and XLI gave 43% XXXV (R = 2-benzothiazolyl, R’ = Me), red crystals, m. 210° (decomposition) (from MeOH). To 2-methylbenzoxazole-p-MeC6H4SO3Et and XLI in hot EtOH was added Et3N, the whole refluxed 3 hrs., cooled, diluted with Et2O, the red tar separated, dissolved in MeOH, and the MeOH diluted with EtI in H2O gave 30% XXXVI (R = H, R’ = Me), red crystals, m. 251° (decomposition) (from EtOH). XV (1.52 g.) and XLI in Ac2O as above gave XXXVI (R = R’ = Me), red crystals, m. 210° (decomposition) (from MeOH). XVI and XLI gave XXXVI (R = Ph, R’ = Me), vermilion crystals, m. 223° (decomposition) (from EtOH). The effect of structure of these dyes on ultraviolet absorption as well as bathochromic shift is discussed.

Compound(6797-13-3)Formula: C9H9NO received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Ethylbenzo[d]oxazole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole(SMILESS: FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1,cas:503538-69-0) is researched.Electric Literature of C13H19ClN2O. The article 《Palladium/Zinc Co-Catalyzed syn-Stereoselectively Asymmetric Ring-Opening Reaction of Oxabenzonorbornadienes with Phenols》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:503538-69-0).

A new palladium/zinc co-catalyst system associated with chiral (R)-Difluorphos for asym. ring-opening reaction of oxabenzonorbornadienes with phenols is reported. This catalyst system allows the formation of cis-2-aryloxy-1,2-dihydronaphthalen-1-ol I (Ar = Ph, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, etc.) and II (R = 5,8-(OCH3)2, 5,8-(CH3)2, 6,7-Br2, 6,7-OCH2O, 6,7-(OCH3)2) products in good yields (up to 95 % yield) with excellent enantioselectivities (up to 99 % ee). The cis-configuration of the product has been confirmed by X-ray crystal structure anal. To the best of our knowledge, it represents the first example in ring-opening reactions of bicycloalkenes with heteronucleophiles in a syn-stereoselective manner.

Compound(503538-69-0)COA of Formula: C38H24F4O4P2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Extensive re-investigations of pressure effects in rhodium-catalyzed asymmetric hydrogenations.Synthetic Route of C38H24F4O4P2.

The catalytic hydrogenation of three prochiral substrates Me Z-α-acetamidocinnamate (MAC), Me 2-acetamidoacrylate (M-Acrylate) and Et 4-methyl-3-acetamido-2-propanoate (E-EMAP) with rhodium precursors complexed with chiral diphosphines is reported at 1-30 bar hydrogen pressure. A library of 56 chiral diphosphines, including 23 BINAP derivatives, 7 JOSIPHOS, 5 BIPHEP, 3 DUPHOS derivatives, and 18 other ligands, was used. While it was generally accepted that high hydrogen pressure would result in lower ees, it is now demonstrated on a statistical basis that an equivalent distribution between beneficial and detrimental pressure effects on ee prevails and that the hydrogen pressure effect on enantioselectivity is not an isolated phenomenon since more than 33% of the reaction systems studied are strongly affected. In some case, the enantioselectivity can be improved up to 97% just by applying a higher hydrogen pressure. Extension of these conclusions to other non-chiral reagents is proposed.

Compound(503538-69-0)Synthetic Route of C38H24F4O4P2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Related Products of 3194-15-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about Inhibition effects of Maillard reaction products derived from L-cysteine and glucose on enzymatic browning catalyzed by mushroom tyrosinase and characterization of active compounds by partial least squares regression analysis. Author is Xu, Haining; Zhang, Xiaoming; Karangwa, Eric.

Inhibition of tyrosinase activity by Maillard reaction products derived from cysteine and glucose (Cys-MRPs) was studied. Pre-incubation of mushroom tyrosinase with Cys-MRPs decreased enzyme activity with increasing reaction time. We show that Cys-MRPs irreversibly block the active site of mushroom tyrosinase and that the competitive inhibitors dithiothreitol and kojic acid protect the enzyme from Cys-MRPs inactivation. Correlation of tyrosinase inhibition ability, volatile compounds, non-volatile compounds (HMF, DDMP and maltol), and Maillard reaction conditions of Cys-MRPs was analyzed by partial least squares regression (PLSR). 3-Ethyl-2-formylthiophene, α-dimethylformylthiophene, 2,6-dimethylpyrazine, ethylpyrazine, 2-ethyl-6-methylpyrazine, 2-methyl-3-(2-thienyldithio) thiophene, and furfural showed a significant and pos. contribution to inhibition ability, while 2-propionylfuran and α-dimethyl-2-formylfuran showed a significant but neg. correlation with inhibition ability. Of the three non-volatile compounds analyzed, only 2,3-dihydro-3,5-dihydroxy-6-methyl-4(H)-pyran-4-one (DDMP) showed a significant and pos. correlation with inhibition ability, while HMF and maltol showed a weak neg. correlation. The reaction temperature and time showed a significant and pos. correlation with inhibition rate, whereas the ratio of sugar to amino acid showed a neg. effect within the exptl. range.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Enantioselective Palladium-Catalyzed Hydrophosphinylation of Allenes with Phosphine Oxides: Access to Chiral Allylic Phosphine Oxides.

A Pd-catalyzed hydrophosphinylation of alkyl and aryl-oxyallenes with phosphine oxides has been developed for the efficient and rapid construction of a family of chiral allylic phosphine oxides with a diverse range of functional groups. This methodol. was further applied in the facile construction of chiral 2H-chromene and later stage functionalization of cholesterol.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Category: benzoxazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about Comparison of determination method for volatile compounds in Thai soy sauce.

Dynamic headspace (DHS) sampling, direct solvent extraction (DSE) and vacuum simultaneous steam distillation-solvent extraction (V-SDE) were used for sample preparation in volatile compound anal. in Thai soy sauce. The extracts obtained from 2 brands were then analyzed by gas chromatog.-mass spectrometry (GC-MS). A comparative study of volatile compounds obtained from these preparation techniques was performed. Some similarities were observed among different characteristic volatile profiles obtained from each preparation technique. Highly volatile compounds were detected only by DHS whereas DSE and V-SDE gave a wide spectrum of chem. classes of compounds detected. Moreover, differences of volatile compounds detected from both soy sauces were noted. This might be due to the differences of production process employed and strains of microorganism used.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Co-Catalyzed Direct Addition of Allylic C(sp3)-H Bonds to Ketones, published in 2017-11-03, which mentions a compound: 503538-69-0, Name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, Molecular C38H24F4O4P2, COA of Formula: C38H24F4O4P2.

By using Co(acac)2/Xantphos with AlMe3, the C(sp3)-H bonds of allylarene derivatives were cleaved for reaction with various ketones, affording the homoallylic alcs. in moderate to good yields. The branch/linear selectivity depended on the steric and electronic factors of the ketone electrophiles. The intermediate in this reaction is thought to be a low-valent allylcobalt(I) species, which exhibits high nucleophilicity toward ketones.

From this literature《Co-Catalyzed Direct Addition of Allylic C(sp3)-H Bonds to Ketones》,we know some information about this compound(503538-69-0)COA of Formula: C38H24F4O4P2, but this is not all information, there are many literatures related to this compound(503538-69-0).

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem