Month: April 2022

Recommanded Product: 1-(Furan-2-yl)propan-1-one. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about Two methods for conversion of an aromatic aldehyde to a 4-arylpyridine. Method for preparation of 3-alkyl-4-arylpyridines. Author is Carbateas, P. M.; Williams, Gordon L..

Nitrophenylpyridines I (R = H, Me, R1 = H) were prepared by cyclizing the propenone II with 2-acylfurans III, oxidizing I (R1 = 2-furyl) and decarboxylating. I (R = R1 = H) was also prepared by cyclizing m-O2NC6H4CHO with HCCCO2Me, aromatizing the di-Me 1,4-dihydro-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, hydrolyzing to the acid and decarboxylating.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthetic Route of C8H8N2S. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Synthesis of Benzo[4,5]imidazo[2,1-b]thiazole by Copper(II)-Catalyzed Thioamination of Nitroalkene with 1H-Benzo[d]imidazole-2-thiol. Author is Jana, Sourav; Chakraborty, Amrita; Shirinian, Valerii Z.; Hajra, Alakananda.

A copper(II)-catalyzed thioamination of β-nitroalkene with 1H-benzo[d]imidazole-2-thiol has been developed for the synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives A variety of N-fused benzoimidazothiazole derivatives were obtained in high yields through successive C-N and C-S bond formations. This protocol is also applicable to β-substitutedβ-nitroalkenes to afford 2,3-disubstituted benzoimidazothiazoles.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Oxidation of certain ketones to acids by alkaline hypochlorite solution》. Authors are Farrar, Martin W.; Levine, Robert.The article about the compound:1-(Furan-2-yl)propan-1-onecas:3194-15-8,SMILESS:O=C(C1=CC=CO1)CC).Safety of 1-(Furan-2-yl)propan-1-one. Through the article, more information about this compound (cas:3194-15-8) is conveyed.

In general, 0.1 mole of the ketone was added dropwise to a stirred solution of 50 g. “”HTH”” [Mathieson Alkali Works trade name for Ca(OCl)2] at 60-70°, residual NaClO destroyed with aqueous NaHSO3, the solution extracted with Et2O, the aqueous phase acidified with HCl, and the crude acids recrystallized from H2O. The following acids (recrystallized from H2O) were prepared: 64% BzOH (from EtBz); 2-thiophenic, m. 129-30° (from Pr 2-thienyl ketone); 67% 5-methyl-2-thiophenic, m. 137-8° (from 5-methyl-2-propionylthiophene); and 59% 2-furoic, m. 131-2° (from Et 2-furyl ketone).

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Brauwelt called New results on the improvement of taste stability of beer, Author is Back, Werner; Forster, Clemens; Krottenthaler, Martin; Lehmann, Jorg; Sacher, Bertram; Thum, Bernhard, which mentions a compound: 3194-15-8, SMILESS is O=C(C1=CC=CO1)CC, Molecular C7H8O2, Product Details of 3194-15-8.

Oxidative processes in aging of beer were described and recommendations were given to optimize taste stability of beer. Taste stability of beer was evaluated by the sum of aging components, sum of temperature indicators, and O2 indicators determined by increases of aging components in a forced-test and by sensory. Taste stability was influenced by barley varieties, growing conditions, malting and kiln-drying processes, mashing and boiling conditions, and by fermentation and storage. The exclusion of O2 influences in different sections of beer production and the optimal addition of reductones were discussed.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, is researched, Molecular C12H25NO5, CAS is 33941-15-0, about Switching Dual Catalysis without Molecular Switch: Using A Multicomponent Information System for Reversible Reconfiguration of Catalytic Machinery, the main research direction is copper zinc terpyridine porphyrinato complex catalyst preparation kinetics.Application In Synthesis of 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane.

Different from the current paradigms of chem., a switchable catalytic system is presented that does not rely on a mol. switch in different toggling states but on a smart seven-component mixture that manages the reversible ON/OFF regulation of two catalytic processes. Hereunto, the workflow of two multicomponent rotary catalytic machineries was interlinked by the simultaneous shuffling of two components (metal and ligand) requiring perfect signaling in a 13-component system (see Movie 1). This network underwent reversible switching over three cycles as demonstrated by 1H NMR, UV-visible, and fluorescence spectroscopies and electrospray ionization mass spectrometry. Addition and removal of zinc(II) ions trigger three distinct events in parallel: the (i) mutually dependent self-assembly of three-component nanorotors and two-component reservoirs by resorting components, (ii) toggling between vastly different rotational exchange rates in the self-assembled rotors that directly affect catalysis, and (iii) toggling between two diverse catalytic reactions in a fully reproducible manner. Because of this information system, the concentrations of free aza-crown ether 7 and its complex with copper(I), i.e., [Cu(7)]+, which represent the effective catalysts, are up- and downregulated in a manner to alternately switch ON/OFF a catalytic conjugate addition and a click reaction.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Pizzetti, Marianna; De Luca, Elisa; Petricci, Elena; Porcheddu, Andrea; Taddei, Maurizio published an article about the compound: 2-Ethylbenzo[d]oxazole( cas:6797-13-3,SMILESS:CCC1=NC2=CC=CC=C2O1 ).Reference of 2-Ethylbenzo[d]oxazole. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:6797-13-3) through the article.

The synthesis of benzimidazoles starting from o-phenylenediamines and amines in the presence of palladium on charcoal as catalyst is reported. Under microwave dielec. heating it is possible to use a tertiary, a secondary, and even a primary amine as the substrate for a palladium-mediated process to get 2-substituted or 1,2-disubstituted benzimidazoles, depending on the nature of the o-phenylenediamine employed. Primary amines are the most suitable reagents for the atom economy of the overall process. Benzoxazoles can be also prepared starting from primary amines and o-aminophenol. The reaction is also highly selective as no (poly)alkylated phenylenediamines or cross-contaminated benzimidazoles are obtained starting from N-monoalkylphenylenediamines. This behavior was interpreted as a scarce aptitude to dehydrogenation of the methylene bonded to the aromatic NH of N-alkylarylamines. The catalyst can be recycled several times and, although far from optimal, catalyst TON=90 is encouraging for further large-scale optimization protocols. In addition, the palladium on charcoal-catalyzed microwave-assisted reaction of o-phenylenediamine gives dealkylation of tertiary amines and transformation to the secondary amines.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

HPLC of Formula: 6797-13-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Ethylbenzo[d]oxazole, is researched, Molecular C9H9NO, CAS is 6797-13-3, about Aldol-type reaction of 2-ethylbenzazoles with aromatic aldehydes in aqueous medium.

The benzoxazole I (X = O) reacted with R1C6H4CHO (R1 = H, 2-Cl, 4-Cl, 2-Me, 4-Me, 4-MeO) in the presence of PhCH2N+Et3Cl- to give II (X = O) as erythro-threo mixtures, except for II (X = O, R1 = 4-MeO) which was pure erythro isomer. Similar reaction of I (X = S) with R1C6H4CHO (R1 = H, 4-Cl, 4-Me, 4-MeO) for 2 h gave II (X = S), whereas after 24 h III were obtained.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Reference of 2-Mercapto-5-methylbenzimidazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Comparative toxicokinetic study of rubber antioxidants, 2-mercaptobenzimidazole and 2-mercaptomethylbenzimidazole, by single oral administration in rats. Author is Sakemi, kazue; Usami, Makoto; Mitsunaga, katsuyoshi; Ohno, Yasuo; Tsuda, Mitsuhiro.

Toxicokinetics of 2-mercaptobenzimidazole (MBI) and 2-mercaptomethylbenzimidazole (MMBI), rubber antioxidants with thioureylene structure, were compared after single oral administration in rats. Male Wistar rats received single oral administration of 2, 10, 50, and 250 mg/kg MBI or MMBI. The serum and urine concentrations of MBI and MMBI were determined by HPLC. MBI and MMBI showed similar Cmax values, but the former disappeared slower in the serum than the latter and resulted in its larger AUC values. Analyses of MBI, MMBI, and their desulfurated metabolites in urine suggested that these differences were due to their metabolic elimination rates. On the other hand, MBI and MMBI caused similar acute toxicities, such as the loss of locomotive activity, ataxic gait, adoption of prone or side position, and coma, being severer with higher serum concentrations at the moment. Similar acute toxicities between MBI and MMBI were explained by similar Cmax values at the same dose. It was suggested from these results that the slower disappearance and larger AUC values of MBI in the serum compared to MMBI might explain the strong thyroid toxicity which has been observed by repeated administration of MBI, but very weak thyroid toxicity by MMBI.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A divergent and selective synthesis of isomeric benzoxazoles from a single N-Cl imine, published in 2011-12-02, which mentions a compound: 6797-13-3, Name is 2-Ethylbenzo[d]oxazole, Molecular C9H9NO, Application In Synthesis of 2-Ethylbenzo[d]oxazole.

A divergent and regioselective synthesis of either 3-substituted benzoisoxazoles or 2-substituted benzoxazoles from readily accessible ortho-hydroxyaryl N-H ketimines is described. The reaction proceeds in two distinct pathways through a common N-Cl imine intermediate: (a) N-O bond formation to form benzoisoxazole under anhydrous conditions and (b) NaOCl mediated Beckmann-type rearrangement to form benzoxazole, resp. The reaction path also depends on the electronic nature of the aromatic ring, with the electron-rich aromatic rings favoring the rearrangement and the electron-deficient rings favoring the N-O bond formation. A Beckmann-type rearrangement mechanism via net [1,2]-aryl migration for the formation of 2-substituted benzoxazole is proposed.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Carbateas, P. M.; Williams, Gordon L. published the article 《Two methods for conversion of an aromatic aldehyde to a 4-arylpyridine. A method for preparation of 3-alkyl-4-arylpyridines》. Keywords: pyridine nitrophenyl; methylpyridine nitrophenyl; nitrophenylpyridine.They researched the compound: 1-(Furan-2-yl)propan-1-one( cas:3194-15-8 ).Application In Synthesis of 1-(Furan-2-yl)propan-1-one. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3194-15-8) here.

Reaction of 1-(2-furyl)-3-(m-nitrophenyl)propenone with 2-acetylfuran (I) and NH4OAc in AcOH at reflux gave 2,6-di(2-furyl)-4-(m-nitrophenyl)pyridine, which was oxidized with dilute HNO3 and the resultant 4-(m-nitrophenyl)-2,6-pyridinedicarboxylic acid decarboxylated by heating with Dowtherm to give 4-(m-nitrophenyl)pyridine (II). II was alternatively prepared by heating a mixture of m-O2NC6H4CHO, CHCCO2Me, and NH4OAc in AcOH at reflux, oxidizing the product (III) with dil HNO3, hydrolyzing the resultant di-Me 4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, and decarboxylating the diacid. 3-Methyl-4-(m-nitrophenyl)pyridine was prepared by replacing I with 2-propionylfuran in the first synthesis.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem