Month: April 2022

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 27231-36-3, is researched, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2SJournal, Article, Research Support, Non-U.S. Gov’t, Scientific Reports called Novel giardicidal compounds bearing proton pump inhibitor scaffold proceeding through triosephosphate isomerase inactivation, Author is Hernandez-Ochoa, B.; Navarrete-Vazquez, G.; Nava-Zuazo, C.; Castillo-Villanueva, A.; Mendez, S. T.; Torres-Arroyo, A.; Gomez-Manzo, S.; Marcial-Quino, J.; Ponce-Macotela, M.; Rufino-Gonzalez, Y.; Martinez-Gordillo, M.; Palencia-Hernandez, G.; Esturau-Escofet, N.; Calderon-Jaimes, E.; Oria-Hernandez, J.; Reyes-Vivas, H., the main research direction is Giardia antiparasitic giardicidal compound proton pump inhibitor triosephosphate isomerase.Synthetic Route of C8H8N2S.

Giardiasis is a worldwide parasitic disease that affects mainly children and immunosuppressed people. Side effects and the emergence of resistance over current used drugs make imperative looking for new antiparasitics through discovering of new biol. targets and designing of novel drugs. Recently, it has determined that gastric proton-pump inhibitors (PPI) have anti-giardiasic activity. The glycolytic enzyme, triosephosphate isomerase (GlTIM), is one of its potential targets. Therefore, we employed the scaffold of PPI to design new compounds aimed to increase their antigiardial capacity by inactivating GlTIM. Here we demonstrated that two novel PPI-derivatives (BHO2 and BHO3), have better anti-giardiasic activity than omeprazole in concentrations around 120-130 muM, without cytotoxic effect on mammal cell cultures. The derivatives inactivated GlTIM through the chem. modification of Cys222 promoting local structural changes in the enzyme. Furthermore, derivatives forms adducts linked to Cys residues through a C-S bond. We demonstrated that PPI can be used as scaffolds to design better antiparasitic mols.; we also are proposing a mol. mechanism of reaction for these novel derivatives

From this literature《Novel giardicidal compounds bearing proton pump inhibitor scaffold proceeding through triosephosphate isomerase inactivation》,we know some information about this compound(27231-36-3)Synthetic Route of C8H8N2S, but this is not all information, there are many literatures related to this compound(27231-36-3).

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Recommanded Product: 3194-15-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about Halogen effects in the reactions of benzylmagnesium halides with furfural and alkyl 2-furyl ketones. Author is Sjoholm, Rainer.

The reactions of PhCH2MgX (X = Cl, Br, I) with furans I (R = H, Me, Et, CHMe2, CMe3) gave 1,2- and 1,4-addition products. The halogen atom of the reagent had a marked effect on the product distribution when R was H, Me, or Et: the heavier the halogen atom, the more 1,2-addition products were formed at the expense of 1,4-addition products.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about In vitro cytotoxicity of the thyrotoxic and hepatotoxic rubber antioxidant 2-mercaptobenzimidazole and its 4- or 5-methyl derivatives in rabbit corneal cells, the main research direction is cytotoxicity hepatotoxicity thyrotoxicity mercaptobenzimidazole.Name: 2-Mercapto-5-methylbenzimidazole.

2-Mercaptobenzimidazole (MBI) and its Me derivatives 4-methyl-MBI (4-MeMBI), 5-methyl-MBI (5-MeMBI), and 4(or 5)-methyl-MBI (4(5)-MeMBI) are widely applied industrial agents with substantial thyrotoxicity and hepatotoxicity detected in rats in vivo. Here, we examined the in vitro cytotoxicity of MBI and its derivates in cultured SIRC rabbit corneal cells. SIRC cells were cultured in the presence of the test chems. for 72 h, and cell viability was determined by estimating the number of cells using a crystal violet staining assay. The median lethal concentration (LC50) was calculated for each of the chems. The Me derivatives showed higher cytotoxicity than MBI, which is in contrast to previous in vivo findings demonstrating higher thyrotoxicity and hepatotoxicity of MBI compared to its derivates. According to the LC50 values, the ranking of the tested agents in terms of cytotoxicity was 5-MeMBI (761.5μM) ≥ 4-MeMBI (796.3μM) ≥ 4(5)-MeMBI (822.9μM) > MBI (1002.9μM). The present results suggest that the lower thyrotoxicity and hepatotoxicity of Me derivatives of MBI is related to their faster detoxification in vivo, because SIRC cells are considered to have lower drug-metabolizing activity than hepatic cells.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Hirano, Masaya; Fukumoto, Yoshiya; Matsubara, Nao; Chatani, Naoto published the article 《A cationic iridium-catalyzed C(sp3)-H silylation of 2-Alkyl-1,3-azoles at the α-position in the 2-alkyl group leading to 2-(1-Silylalkyl)-1,3-azoles》. Keywords: cationic iridium catalyzed regioselective silylation alkylazole alpha position alkyl; silylalkylazole preparation.They researched the compound: 2-Ethylbenzo[d]oxazole( cas:6797-13-3 ).Product Details of 6797-13-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:6797-13-3) here.

The regioselective silylation of the α-C(sp3)-H bond in the 2-alkyl group in 2-alkyl-1,3-azole derivatives with hydrosilanes, catalyzed by the combination of (POCOPtBu)IrHCl and NaBArF4, leading to the production of 2-(1-silylalkyl)-1,3-azoles is described. The presence of 3,5-dimethylpyridine is required for the reaction to proceed. Although the reaction takes place both in the presence and absence of a hydrogen acceptor, the addition of an acceptor gave better results, in terms of the efficiency of the reaction.

From this literature《A cationic iridium-catalyzed C(sp3)-H silylation of 2-Alkyl-1,3-azoles at the α-position in the 2-alkyl group leading to 2-(1-Silylalkyl)-1,3-azoles》,we know some information about this compound(6797-13-3)Product Details of 6797-13-3, but this is not all information, there are many literatures related to this compound(6797-13-3).

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole(SMILESS: FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1,cas:503538-69-0) is researched.Formula: C12H9NO2. The article 《Palladium-Catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:503538-69-0).

A palladium-catalyzed asym. reductive Heck reaction of unactivated aliphatic alkenes, with eliminable β-hydrogen atoms, was realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing chiral quaternary and tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibited good functional-group tolerance and scalability. Moreover, deuterated optically active bicyclo[3.2.1]octanes were also obtained in high efficiency.

There is still a lot of research devoted to this compound(SMILES：FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1)Application of 503538-69-0, and with the development of science, more effects of this compound(503538-69-0) can be discovered.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 503538-69-0, is researched, Molecular C38H24F4O4P2, about Catalytic Enantioselective Double Carbopalladation/C-H Functionalization with Statistical Amplification of Product Enantiopurity: A Convertible Linker Approach, the main research direction is methacrylamide iodophenyl methyl oxadiazole palladium dimerization catalyst; oxadiazole bis dimethylindolinone stereoselective preparation; C−H activation; asymmetric synthesis; heterocycles; homogeneous catalyst; palladium.Related Products of 503538-69-0.

Combining a catalytic enantioselective reaction with dimerization in a single operation is an efficient way to upgrade the enantiomeric excesses (ee) of the product. Palladium-catalyzed reaction of N-(2-iodophenyl)-N-Me methacrylamide derivatives with oxadiazole afforded, by a double enantioselective carbopalladation/intermol. heteroarene C-H alkylation sequence, homodimers I (R1 = H, 5-OMe, 5-Cl, 6-Cl, etc.; R2 = Me, Bn, i-Pr, etc.) in good yields with excellent ee values. The dimer was subsequently elaborated to the monomer in which the linker (oxadiazole) was incorporated into the target product.

There is still a lot of research devoted to this compound(SMILES：FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1)Related Products of 503538-69-0, and with the development of science, more effects of this compound(503538-69-0) can be discovered.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Mercapto-5-methylbenzimidazole( cas:27231-36-3 ) is researched.Synthetic Route of C8H8N2S.Sorba, Giovanni; Garrone, Adele; Serafino, Anna; Gasco, Alberto; Orsetti, Marco published the article 《Potential histamine H2-receptor antagonists: ranitidine analogs containing 2-amino-5(6)-substituted benzimidazole moieties. (1)》 about this compound( cas:27231-36-3 ) in European Journal of Medicinal Chemistry. Keywords: ranitidine analog preparation antihistaminic; aminobenzimidazole preparation antihistaminic; structure antihistaminic activity aminobenzimidazole. Let’s learn more about this compound (cas:27231-36-3).

A series of ranitidine analogs (I: R = H, Me, OMe, Cl, CONH2, CN, and NO2) were synthesized and tested for its in vitro H2-antagonism by using the histamine induced guinea pig atria chronotropic response. These substances generally display good H2-antagonist activity. Some considerations of the structure relationships are also discussed, in particular the physicochem. properties of the benzimidazole moiety.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Application of 6797-13-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Ethylbenzo[d]oxazole, is researched, Molecular C9H9NO, CAS is 6797-13-3, about Tungstate sulfuric acid as an efficient catalyst for the synthesis of benzoxazoles and benzothiazoles under solvent-free conditions. Author is Farahi, Mahnaz; Karami, Bahador; Azari, Masume.

Tungstate sulfuric acid (TSA) was found to be an efficient and reusable catalyst for the synthesis of benzoxazole and benzothiazole derivatives via reactions of ortho esters with o-aminophenols or o-aminothiophenols in high yields.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Asymmetric hydrogenation of quinolines with recyclable and air-stable iridium catalyst systems, the main research direction is quinoline asym hydrogenation recyclable iridium catalyst; tetrahydroquinoline alkyl asym synthesis.Reference of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

The iridium complex-catalyzed asym. hydrogenation of quinolines in a poly(ethylene glycol) di-Me ether (DMPEG)/hexane biphasic system was studied. Catalysts with C2-sym. ligands such as Xyl-P-Phos, Cl-MeO-BIPHEP, SYNPHOS, and DifluorPhos are highly effective for this type of reaction. Most of the catalysts tested can be retained in DMPEG (Mn = 500), and the asym. hydrogenation of various quinoline substrates can be carried out in DMPEG/hexane biphasic system with up to 92% ee. The catalysts and the products can be separated via simple phase separation, and the reactivity/stereoselectivity of the catalysts can be retained for at least three reaction cycles.

There is still a lot of research devoted to this compound(SMILES：FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1)Reference of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and with the development of science, more effects of this compound(503538-69-0) can be discovered.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

COA of Formula: C9H9NO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Ethylbenzo[d]oxazole, is researched, Molecular C9H9NO, CAS is 6797-13-3, about Reaction of benzoxa(thia)zoles with allenylmagnesium bromide. Synthesis of propargylbenzothiazolines and dipropargylalkyl-o-aminophenols. Author is Babudri, F.; Florio, S..

Benzoxazoles I (R = H, alkyl, CH2Ph; X = O) and benzothiazole I (R = H; X = S) react with H2C:C:CHMgBr (II) (prepared from propargyl bromide) to give 2-HOC6H4NHC(CH2CCH)2R and disulfide III resp. The reaction of I (R = alkyl, CH2Ph; X = S) with II gives the propargylbenzothiazolines IV and I (R = OMe; X = S) produces I (R = CH:C:CH2; X = S).

There is still a lot of research devoted to this compound(SMILES：CCC1=NC2=CC=CC=C2O1)COA of Formula: C9H9NO, and with the development of science, more effects of this compound(6797-13-3) can be discovered.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem