Month: April 2022

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Action of mixed organomagnesium compounds on N-disubstituted amides of α-furoic acid》. Authors are Maxim, N.; Zugravescu, I.; Fulga, I..The article about the compound:1-(Furan-2-yl)propan-1-onecas:3194-15-8,SMILESS:O=C(C1=CC=CO1)CC).Category: benzoxazole. Through the article, more information about this compound (cas:3194-15-8) is conveyed.

In aromatic series of keto amides, BzNR2, the action of the Grignard reagent produces ketones except in the instance of BzNEt2, where PhMgBr gave in addition Ph3CNEtPh (Busch and Fleischmann, C. A. 4, 3237). The action of the Grignard reagent has been studied on furoylanilides prepared by the action of α- furoyl chloride (I) on PhNHMe, PhNHEt and Ph2NH. A mixture of 136 g. PhNHMe and 250 g. of anhydrous benzene was treated dropwise with 83 g. I. The filtered benzene solution was washed, dried and evaporated and the crude product was recrystallized from benzene or alc., yielding 90% of α-furoyl-N-methylanilide (II), C12H11NO2, m. 120°. Similarly were prepared the corresponding ethylanilide (III), m. 127°, and diphenylamide (IV), C17H13NO2, m. 157°, in 90 and 80% yields, resp. II (20 g.) was added portionwise with stirring to 35 g. EtMgBr in 160 g. Et2O and, after 12 h., the product was decomposed with 25% HCl. The Et2O layer yielded a crude product, b63 100-40°, which was washed with 30% HCl and extracted with Et2O, giving 4 g. of α- furyl Et ketone (V), b63 120°; semicarbazone, m. 172°. Treatment of II with iso-BuMgCl similarly gave α- furyl iso-Bu ketone (VI), b26 110°; semicarbazone, m. 174°. With III, EtMgBr and iso-BuMgCl gave only V and VI but the crude product obtained by the action of PhMgBr yielded α- furyl Ph ketone (VII), b25 197°, and the tertiary base, ethyl(furyldiphenylmethyl)aniline, C25H23NO, m. 181°. Treatment of III with o-MeC6H4MgBr gave the oily α- furyl o-tolyl ketone (VIII), C12H10O2, b22 177°. Similarly with IV, the Grignard reagents EtMgBr, iso-BuMgCl, o-MeC6H4MgBr and PhMgBr produced V, VI, VIII and VII. The behavior of the furyl series of keto amides is thus analogous to that of the aromatic series in every respect.

Different reactions of this compound(1-(Furan-2-yl)propan-1-one)Category: benzoxazole require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Chromatography A called Elucidation of the aroma compositions of Zhenjiang aromatic vinegar using comprehensive two dimensional gas chromatography coupled to time-of-flight mass spectrometry and gas chromatography-olfactometry, Author is Zhou, Zhilei; Liu, Shuangping; Kong, Xiangwei; Ji, Zhongwei; Han, Xiao; Wu, Jianfeng; Mao, Jian, which mentions a compound: 3194-15-8, SMILESS is O=C(C1=CC=CO1)CC, Molecular C7H8O2, Computed Properties of C7H8O2.

In this work, a method to characterize the aroma compounds of Zhenjiang aromatic vinegar (ZAV) was developed using comprehensive two dimensional gas chromatog. (GC × GC) coupled with time-of-flight mass spectrometry (TOFMS) and gas chromatog. olfactometry (GC-O). The column combination was optimized and good separation was achieved. Structured chromatograms of furans and pyrazines were obtained and discussed. A total of 360 compounds were tentatively identified based on mass spectrum match factors, structured chromatogram and linear retention indexes comparison. The most abundant class in number was ketones. A large number of esters, furans and derivatives, aldehydes and alcs. were also detected. The odor-active components were identified by comparison of the reported odor of the identified compounds with the odor of corresponding GC-O region. The odorants of methanethiol, 2-methyl-propanal, 2-methyl-butanal/3-methyl-butanal, octanal, 1-octen-3-one, di-Me trisulfide, trimethyl-pyrazine, acetic acid, 3-(methylthio)-propanal, furfural, benzeneacetaldehyde, 3-methyl-butanoic acid/2-methyl-butanoic acid and phenethyl acetate were suspected to be the most potent. About half of them were identified as significant aroma constituents in ZAV for the first time. Their contribution to specific sensory attribute of ZAJ was also studied. The results indicated that the presented method is suitable for characterization of ZAV aroma constituents. This study also enriches our knowledge on the components and aroma of ZAV.

Different reactions of this compound(1-(Furan-2-yl)propan-1-one)Computed Properties of C7H8O2 require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole(SMILESS: FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1,cas:503538-69-0) is researched.Reference of 2-Ethylbenzo[d]oxazole. The article 《Iridium-catalyzed asymmetric hydrogenation of pyridinium salts》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:503538-69-0).

A highly efficient iridium-catalyzed asym. hydrogenation of 2-substituted pyridinium salts is developed. A series of chiral 2-substituted piperidines were obtained in good to excellent yields and up to 93% ee.

Different reactions of this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole)Recommanded Product: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Catalytic synthesis of 2-alkylbenzoxazoles》. Authors are Kozlov, N. S.; Kiselev, B. I..The article about the compound:2-Ethylbenzo[d]oxazolecas:6797-13-3,SMILESS:CCC1=NC2=CC=CC=C2O1).Reference of 2-Ethylbenzo[d]oxazole. Through the article, more information about this compound (cas:6797-13-3) is conveyed.

A mixture of 0.1 mole o-nitrophenol and 0.3 mole ROH( R = alkyl) was passed at the rate of 20 g./hr. over Cu-Al2O3 catalyst kept at 300-10°, unreacted material distilled and the residue worked up with alkali, washed with H2O, and dried to yield 2-alkylbenzoxazoles (R, b.p./mm., d20, n20D, and % yield given): H, 180-2°/760, -,-, 20; Me, 201°/760, 1.12, 1.5531, 31; Et, 98-9°/10, 1.0879, 1.5420, 34; Pr, 116-18°/10, 1.066, 1.5338, 69; iso-Pr, 109-11°/10, 1.0799, 1.5391, 32; Bu, 133-5°/10, 1.042, 1.5271, 21; iso-Bu, 120-2°/10, 1.028, 1.5090, 15; C5H11, 145-7°/10, 1.0072, 1.5173, 30; C6H13, 164-5°/10, 0.983, 1.5000, 25; C7H15, 176-8°/10, 0.943, 1.4818, 30; C8H17 (m. 26°), -, -, 27; and C9H19, (m. 22-3°), -, -, 20. Ir spectra are discussed.

Different reactions of this compound(2-Ethylbenzo[d]oxazole)Reference of 2-Ethylbenzo[d]oxazole require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Desymmetrization of 1,4-Cyclohexadienyltriisopropoxysilane Using Copper Catalysis.Quality Control of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

The first catalytic desymmetrization in the field of allylsilane chem. is presented. Desymmetrization of cyclohexadienyltriisopropoxysilane is achieved using copper catalysis. High diastereo- and enantioselectivities are obtained, and the product dienes are highly valuable building blocks for natural product synthesis.

Different reactions of this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole)Quality Control of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

SDS of cas: 3194-15-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about Effect of thermal treatment on the flavor generation from Maillard reaction of xylose and chicken peptide. Author is Liu, Jianbin; Liu, Mengya; He, Congcong; Song, Huanlu; Chen, Feng.

In this research, effect of the thermal treatment on the flavor generation from Maillard reaction of xylose and chicken peptide was studied. In summary, high temperature (>100 °C) could remarkably increase the formation of meaty aroma generated by xylose and chicken peptide through a Maillard reaction system, while lower temperature and longer heating tended to generate a broth-like taste (i.e., umami and kokumi). Pyrazines were the major contributors to the nutty/roast and basic meaty aroma in the Maillard reaction products (MRP), while the Glu released under the low temperature heating was considered an important contributor to the umami taste of MRPs. The low mol. weight peptide (<500 Da) was considered as the main contributor of the generation of pyrazines and 2-furfurylpyrrole, which could be due to the high reaction activity of the amidogen in these compounds In addition, crosslinking compounds with mol. weight >1000 Da formed from peptides <500 Da in the low temperature heating might be involved in formation of important kokumi-active compounds, while the high mol. compounds MRPs >3000 Da were very likely responsible for the bitter taste.

The article 《Effect of thermal treatment on the flavor generation from Maillard reaction of xylose and chicken peptide》 also mentions many details about this compound(3194-15-8)SDS of cas: 3194-15-8, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Analytica Chimica Acta called Polarographic study of an alkyl benzimidazolyl sulfoxide and the corresponding sulfide and sulfone, Author is Johansson, Bo Lennart; Persson, Bjorn, which mentions a compound: 27231-36-3, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2S, Synthetic Route of C8H8N2S.

2-(5-Methylbenzimidazolyl)-1-(2-pyridyl)ethyl sulfide (I), II [69417-07-8], and III [69417-08-9] were reduced at a dropping Hg electrode in aqueous EtOH. Coulometric experiments at a Hg pool prove that 2-ethylpyridine [100-71-0] and 2-mercapto-5-methylbenzimidazole [27231-36-3] were formed in the reduction process of the sulfide and the sulfoxide. Coulometric reduction of the sulfone results in some conversion of the pyridine 1-oxide group together with a reductive fission of the ethyl-sulfonyl bond. One of these fission products undergoes secondary reactions. The concentration of 2-benzimidazolyl 2-pyridylmethyl sulfoxide (IV) [57237-97-5] in a pharmaceutical formulation was determined by differential pulse polarog.

The article 《Polarographic study of an alkyl benzimidazolyl sulfoxide and the corresponding sulfide and sulfone》 also mentions many details about this compound(27231-36-3)Synthetic Route of C8H8N2S, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Electric Literature of C38H24F4O4P2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates.

For the first time, the asym. hydrogenation of quinoxaline-2-carboxylates was performed successfully. The best catalysts are based on iridium complexes modified by chiral phosphorous ligands. Accelerated examination of ligands and catalysts has been undertaken by using a Chemspeed workstation (automated instrument) workstation enables carrying out, in parallel, eight independent catalytic reactions at the laboratory scale. Tetrahydroquinoxaline-2-carboxylates could be obtained with high yields and up to 74% ee. The synthesis of the target compounds was achieved using chiral ligands, such as (11aR)-10,11,12,13-tetrahydro-N,N-dimethyldiindeno[7,1-de:1′,7′-fg][1,3,2]dioxaphosphocin-5-amine [i/e/. (R)-siphos], 1,1′-[(1S)-6,6′-dimethoxy[1,1′-biphenyl]-2,2′-diyl]bis[1,1-diphenylphosphine] [i.e., (S)-MeO-BIPHEP], (R)-Cl-MeO-BIPHEP, (R)-difluorphos, (R)-GARPHOS, (R)-P-PHOS, (S)-C3-TUNEPHOS [i.e., 1,1′-[(13aS)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonin-1,13-diyl]bis[1,1-diphenylphosphine]], (S)-SEGPHOS, (S)-Xyl-SolPhos, CATASium T3, N-[(1R)-2-[(11bR)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yloxy]-1-methylethyl]-N’-phenylurea [i.e., ureaphos], SL-J404-1, SL-J006-1, SL-J002-1, SL-J003-1, SL-J009-1, SL-T002-1, SL-W006-1. Pre-catalysts included bis(acetato-κO,κO’)[(4R)-1,1′-[4,4′-bi-1,3-benzodioxole]-5,5′-diylbis[1,1-diphenylphosphine-κP]]ruthenium [i.e., Ru(OAc)2[(R)-segphos]], [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium [i.e., RuCl[(R,R)-TsDPEN][p-cymene]] and [1,1′-(1S)-[4,4′-bi-1,3-benzodioxole]-5,5′-diylbis[1,1-diphenylphosphine-κP]][4-cyano-3-nitrobenzenecarboxylato(2-)-κC6,κO1](η3-2-propen-1-yl)iridium.

The article 《First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates》 also mentions many details about this compound(503538-69-0)Electric Literature of C38H24F4O4P2, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, ACS Sustainable Chemistry & Engineering called Long-Chained Acidic Ionic Liquids-Catalyzed Cyclization of 2-Substituted Aminoaromatics with β-Diketones: A Metal-Free Strategy to Construct Benzoazoles, Author is Miao, Chengxia; Hou, Qin; Wen, Yating; Han, Feng; Li, Zhen; Yang, Lei; Xia, Chun-Gu, which mentions a compound: 6797-13-3, SMILESS is CCC1=NC2=CC=CC=C2O1, Molecular C9H9NO, HPLC of Formula: 6797-13-3.

With long-chained acidic ionic liquids as catalysts, a metal-free, efficient, and universal strategy was developed to synthesize a series of benzoazole compounds through intermol. cyclization of 2-aminophenols/thiophenols/anilines with β-diketones. Compared with traditional ionic liquids, the long-chained ionic liquids with certain surfactivity exhibited better catalytic activities perhaps for micellar action and could be reused at least six times. A mechanism that involves condensation, nucleophilic addition, and C-C bond cleavage was proposed, and the imine compound was recognized as an important intermediate in the reaction.

The article 《Long-Chained Acidic Ionic Liquids-Catalyzed Cyclization of 2-Substituted Aminoaromatics with β-Diketones: A Metal-Free Strategy to Construct Benzoazoles》 also mentions many details about this compound(6797-13-3)HPLC of Formula: 6797-13-3, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthetic Route of C7H8O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about Unusual course of the Meerwein reaction in the furan series. Author is Markova, I. G.; Polievktov, M. K.; Oleinik, A. F.; Modnikova, G. A..

Meerwein reaction of p-XC6H4N2+ Cl- (X = Cl, Br, NO2) with furyl ketones I (R = Me, Et, Pr) gave II and III. II is not an intermediate in the formation of III. Polarog. indicated that RCHO were present in the reaction mixture which agreed with IV as a proposed intermediate; IV lost RCHO to give III.

The article 《Unusual course of the Meerwein reaction in the furan series》 also mentions many details about this compound(3194-15-8)Synthetic Route of C7H8O2, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem