Month: October 2022

On July 15, 2015, Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D.; Brauner-Osborne, Hans; Kristensen, Jesper Langgaard published an article.Formula: C9H7NO3 The title of the article was Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. And the article contained the following:

N-Benzyl substitution of phenethylamine 5-HT2A receptor agonists has dramatic effects on binding affinity, receptor selectivity and agonist activity. In this paper we examine how affinity for the 5-HT2A/2C receptors are influenced by N-benzyl substitution of 4-bromo-2,5-dimethoxyphenethylamine derivatives Special attention is given to the 2′ and 3′-position of the N-benzyl as such compounds are known to be very potent. We found that substitutions in these positions are generally well tolerated. The 2′-position was further examined using a range of substituents to probe the hydrogen bonding requirements for optimal affinity and selectivity, and it was found that small changes in the ligands in this area had a profound effect on their affinities. Furthermore, two ligands that lack a 2′-benzyl substituent were also found to have high affinity contradicting previous held notions. Several high-affinity ligands were identified and assayed for functional activity at the 5-HT2A and 5-HT2C receptor, and they were generally found to be less efficacious agonists than previously reported N-benzyl phenethylamines. The experimental process involved the reaction of Methyl benzo[d]oxazole-7-carboxylate(cas: 1086378-35-9).Formula: C9H7NO3

The Article related to bromodimethoxy phenethyl amine preparation 5ht2a 5ht2c agonist, 5-ht(2a) agonists, n-benzyl phenethylamines, selectivity, serotonin, structure activity relations, Pharmacology: Structure-Activity and other aspects.Formula: C9H7NO3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On January 6, 2022, Tobita, Hidekatsu; Nakano, Takaaki; Nokura, Yoshihiko published a patent.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Method for controlling soybean rust fungus having resistance to QOI fungicide. And the patent contained the following:

The invention relates to a method for controlling soybean rust fungus using a compound that has an amino acid substitution of F129L in the mitochondrial cytochrome b protein. The compound is represented by formula (I) I [wherein, R1 = C1-4 alkyl group or the like, n = 0, 1, or 2, Q = a group or the like represented by Q1, a binding site with respect to the remaining portion of the mol., X1 = -C(H)= or the like, X2 represents -C(O)OCH3 or the like, J is a group or the like represented by J1, indicates a binding position with respect to E, Y1 = oxygen atom or the like, Y2 = C(R6)- or the like, R6 = C1-4 alkyl group or the like, and E = C1-6 chain-like hydrocarbon group or the like]. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to qoi fungicide resistant soybean rust fungus control, Agrochemical Bioregulators: Microbial and other aspects.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On March 5, 2020, Mete, Antonio; Hitchin, James R.; Graham, Mark published a patent.Safety of Methyl benzo[d]oxazole-7-carboxylate The title of the patent was Heterocyclic compounds as ARH modulators for treatment of diseases, in particular cancer. And the patent contained the following:

The present invention relates compounds of the general formula (I) or (II) which are ARH inhibitors, methods for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds and pharmaceutical compositions for the treatment or prevention of diseases, in particular cancer or conditions with dysregulated immune functions, or other conditions associated with aberrant AHR signaling, as a sole agent of in combination with other active ingredients. Such compounds may also be of utility in the expansion of hematopoietic stem cells (HSCs) and the use of HSCs in autologous or allogenic transplantation for the treatment of patients with inherited immunol. and autoimmune diseases and diverse hematopoietic disorders. The experimental process involved the reaction of Methyl benzo[d]oxazole-7-carboxylate(cas: 1086378-35-9).Safety of Methyl benzo[d]oxazole-7-carboxylate

The Article related to heterocyclic arh modulator signaling cancer, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of Methyl benzo[d]oxazole-7-carboxylate

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On July 14, 2022, Zhang, Kongyan; Ma, Tiantian; Zhang, Heming published a patent.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Carbazole-triazine compound, and electronic element and electronic device using same. And the patent contained the following:

The application relates to carbazole-triazine compounds I, and electronic elements and electronic devices using same. Compounds of formula I wherein T is -(L3-L4-A2)m; A1 and A2 are independently (un)substituted benzoxazolyl, (un)substituted triazinyl, etc.; m is 1-2; L1-L4 are independently a single bond, (un)substituted C6-30 arylene, C2-30 heteroarylene; R1 and R2 are independently D, halo, C1-10 alkyl, C3-10 cycloalkyl, C1-10 alkoxy, C6-30 aryl, etc.; n1 and n2 are independently 0-4; and their preparation method, as well as the use in OLEDs thereof, are claimed. Example compound II was prepared by using reductive cyclization, Suzuki cross coupling and condensation as the key steps. The organic compounds I provided in the present application can be used in organic electroluminescent devices, and can improve the performance of the organic electroluminescent devices. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to carbazole triazine preparation oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On July 12, 2022, Zhang, Kongyan; Ma, Tiantian; Zhang, Heming published a patent.Formula: C13H8BrNO The title of the patent was Carbazole-triazine compound, and electronic element and electronic device using same. And the patent contained the following:

The present application relates to an organic compound and electronic component and electronic device using the same. The organic compound has a structure represented by the following formula 1, wherein A1 and A2 are independently selected from a structure represented by formula 2 or formula 3; m is 1 or 2. The organic compounds provided herein can be used in an organic electroluminescent device to improve the performance of the organic electroluminescent device. The application relates to carbazole-triazine compounds I, and electronic elements and electronic devices using same. Compounds of formula I wherein T is -(L3-L4-A2)m; A1 and A2 are independently (un)substituted benzoxazolyl, (un)substituted triazinyl, etc.; m is 1-2; L1-L4 are independently a single bond, (un)substituted C6-30 arylene, C2-30 heteroarylene; R1 and R2 are independently D, halo, C1-10 alkyl, C3-10 cycloalkyl, C1-10 alkoxy, C6-30 aryl, etc.; n1 and n2 are independently 0-4; and their preparation method, as well as the use in OLEDs thereof, are claimed. Example compound II was prepared by using reductive cyclization, Suzuki cross coupling and condensation as the key steps. The organic compounds I provided in the present application can be used in organic electroluminescent devices, and can improve the performance of the organic electroluminescent devices. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Formula: C13H8BrNO

The Article related to carbazole triazine preparation oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On June 25, 2021, Ma, Tiantian; Zhang, Kongyan; Li, Xinxuan; Zheng, Yiyi published a patent.Synthetic Route of 1268137-13-8 The title of the patent was Nitrogen-containing compound, electronic component and electronic device containing the same. And the patent contained the following:

The present invention relates to a nitrogen-containing compound that is represented by the formula I, wherein A and B are independently C6-C30 (un)substituted aryl, aryl, etc.; U1, U2 and U3 are independently selected from N or C(R), and at least one of U1, U2 and U3 is N; each of R, R1, R2, R3, R4, and R5 is independently selected from hydrogen, deuterium, halogen group, cyano group, etc.; n1, n2, n3, n4, n5 are selected from 1, 2, 3 or 4, when n1-n5 is greater than 1; X is selected from S or O; L, L1, L2, L3 and L4 are independently selected from single bonds, (un)substituted arylene groups having 6-30 carbon atoms, and (un)substituted heteroarylene group having 3-30 carbon atoms; and Ar1 and Ar2 are independently selected from (un)substituted aryl groups having 6-30 carbon atoms, and (un)substituted heteroaryl groups having 3-30 carbon atoms. The nitrogen-containing compound can be used in the light-emitting layer material of an organic electroluminescent device, improving the electron transport performance of the device, and improving the luminous efficiency and service life of the device. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Synthetic Route of 1268137-13-8

The Article related to nitrogen carbazole heterocyclic compound application oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Synthetic Route of 1268137-13-8

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On November 2, 2021, Yang, Min published a patent.Formula: C13H8BrNO The title of the patent was Preparation of triazine derivatives and their application in OLED. And the patent contained the following:

The present invention relates to preparation of triazine derivatives and their application in OLED. In particular the preparation of compound containing I, II and III (wherein, * represents the connection site of I and II; I is connected to the two adjacent connection points in II; A is the connection site of III; wherein, ring B represents C10-20 aromatic ring; X = S or O; Het = C3-20 heteroarylene group and contains at least two N atoms ; L1, L2 and L3 = a single bond, (un)substituted C6-30 arylene, C3-30 heteroaryl; Ar1, Ar2 and Ar3 = hydrogen, (un)substituted C6-30 aryl or C3-30 heteroaryl groups; the substituents in L1, L2, L3, Ar1, Ar2 and Ar3 = deuterium, halogen, cyano, C3-20 heteroaryl, C6-20 aryl, C1-10 alkyl, C1-10 haloalkyl, C2-10 heterocycloalkyl, C1-10 alkoxy; optionally, in Ar1 and Ar2, any two adjacent substituents form a ring). Further, (R1, R2 and R3 = hydrogen, deuterium, halogen, cyano, C6-C20 aryl, C3-C30 heteroaryl, C3-C12 trialkylsilyl, C1-C10 alkyl, C1-10 haloalkyl, C3-10 cycloalkyl, C2-10 heterocycloalkyl or C1-10 alkoxy; n1 = 1, 2, 3 or 4; when n1 is greater than 1, any two R1s are the same or different, optionally, any two adjacent R1 form a ring; n2 = 1 or 2; when n2 is greater than 1, any two R2s are the same or different, optionally, any two adjacent R2s form a ring; n3 = 1, 2, 3, or 4; when n3 is greater than 1, any two R3s are the same or different, and optionally, any two adjacent R3s form a ring). The inventive triazine compound can effectively improve the light-emitting efficiency of the device, reduce the voltage of the device and prolong the service life of the organic electroluminescent device. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Formula: C13H8BrNO

The Article related to triazine derivative preparation organic electroluminescent device, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On March 1, 2022, Ma, Tiantian; Zheng, Yiyi; Xu, Jiacong published a patent.Category: benzoxazole The title of the patent was Preparation of heterocyclic nitrogen compounds for organic electroluminescent device. And the patent contained the following:

The present invention relates to the preparation of heterocyclic nitrogen compounds for organic electroluminescent device. In particular, the preparation of compound I (wherein, * represents a connection site, ring A, B and C = C6-14 aryl and are not benzene rings at the same time; in formula II * is the bond which represents fusion on any two adjacent carbon atoms of ring B in I; U1, U2 = (un)substituted [C6-30 aryl, C3-30 heteroaryl] or a structure shown in formula III or IV, and at least one of U1 and U2 is selected from formula III or IV; X = S or O; X1, X2 and X3 = N or C(R), and at least one of X1, X2 and X3 is N; E1 = (R1)n1; E2 = (R2)n2; E3 = (R3)n3; E4 = (R4)n4; E5 = (R5)n5; R1-5 = hydrogen, deuterium, halogen, cyano, C6-12 aryl, C5-12 heteroaryl, C1-5 alkyl, C1-5 haloalkyl, C1-5 deuterated alkyl, C3-12 trialkylsilyl). Further, (n1, n2 represents the number of substituents R1 and R2 resp.; n1, n2 = 1-8, when n1 or n2 is greater than 1, any two R’s are the same or different, optionally, any two adjacent R’s form a ring; n3 represents the number of substituent R3, n3 = 1-6, when n3 is greater than 1, any two R3 are the same or different, optionally, any two adjacent R3 form a ring; n4 represents the number of substituent R4, n4 = 1-3, when n4 is greater than 1, any two R4 are the same or different, any optionally, any two adjacent R4 form a ring). Also, (n5 represents the number of substituent R5, n5 = 1-4, when n5 is greater than 1, any two R5 is the same or different, optionally, any two adjacent R5 form a ring; L, L1-4 = a single bond, (un)substituted [C6-30 arylene, C3-30 heteroarylene]; Ar1 and Ar2 = (un)substituted [C6-30 aryl, C3-30 heteroaryl]; the substituents in the U1, U2, L, L1-4, Ar1 and Ar2 = deuterium, halogen, cyano, C3-20 heteroaryl, C6-20 aryl, C3-12 trialkylsilyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 deuterated alkyl, C3-10 cycloalkyl, C2-10 heterocycloalkyl or C1-10 alkoxy; optionally, in Ar1 and Ar2, any two adjacent substituents form a ring). The inventive compound having a fused heteroaromatic ring as a hole transporting group and a nitrogen-containing heteroaryl group as an electron transporting group is suitable for use in an organic electroluminescent device, and the performance of the organic electroluminescent device can be significantly improved. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Category: benzoxazole

The Article related to heterocyclic nitrogen compound preparation hole transport material oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On March 12, 2019, Xu, Fawang; Xu, Yulin; Zhang, Heng; Li, Yanlong; Zhang, Xin; Yu, Hao published a patent.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Preparing method and application of umbrella-shaped novel luminescent material containing pyrrole structure. And the patent contained the following:

The invention disclosed a kind of umbrella-shaped novel luminescent material containing pyrrole structure, its preparation method and application. The claimed compound is shown in structure I (Ar = (un)substituted C6-60 aryl, containing one or more N, O, or S (un)substituted heteroaryl). The claimed compound is prepared via multiple steps (procedure given). The prepared compound can be used in OLED with high mol. stability, excellent photoelec. properties, high heat stability, low drive voltage, high efficiency, and long service life. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to umbrella shaped pyrrole luminescent substance preparation oled, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On March 11, 2015, Sasmal, Swarnendu; Sen, Indira; Hall, Roger G.; Pal, Sitaram published an article.Computed Properties of 1086378-35-9 The title of the article was Intermolecular coupling of 2-iodoanilides with benzoxazoles: synthesis of N-(2-benzoxazol-2-ylphenyl)benzamides via C-H activation. And the article contained the following:

Using CuI/xantphos/Pd(OAc)2 catalytic system, the intermol. C-C cross-coupling between benzoxazoles and o-iodoanilides has been developed in moderate to good yields. The procedure tolerates a series of functional groups on benzoxazole, such as ester, chloro, Me, and methoxy groups. This divergent approach provides access to various N-(2-benzoxazol-2-ylphenyl)amides. The experimental process involved the reaction of Methyl benzo[d]oxazole-7-carboxylate(cas: 1086378-35-9).Computed Properties of 1086378-35-9

The Article related to arylation benzoxazole iodoanilide copper palladium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Computed Properties of 1086378-35-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem