Day: October 14, 2022

Paun, Anca; Matache, Mihaela; Enache, Florina; Nicolau, Ioana; Paraschivescu, Codruta C.; Ionita, Petre; Zarafu, Irina; Parvulescu, Vasile I.; Guillaumet, Gerald published the artcile< Convenient synthesis of 2-alkynylbenzazoles through Sonogashira cross-coupling reaction between thioethers and terminal alkynes>, COA of Formula: C7H4FNOS, the main research area is alkynylbenzoxazole alkynylbenzothiazole preparation; heteroaryl thioether terminal alkyne Sonogashira cross coupling.

Synthesis of 2-alkynylbenzoxazole and 2-alkynylbenzothiazole derivatives, e.g., I and II resp., via Sonogashira cross-coupling reaction of the corresponding thioethers and terminal alkynes under aerobic conditions, using CuI and Pd(dppf)Cl2 as catalysts was described. This synthetic methodol. allows the convenient cross-coupling of heteroaromatic substrates with a wide variety of aromatic and aliphatic alkynes, in moderate to good yields. The behavior of mercapto benzoxazoles and benzothiazoles were also investigated in the desulfitative Sonogashira cross-coupling reaction. It is noteworthy that the reaction occurred better under aerobic conditions rather than an inert atm., although with increased amounts of the diyne side-product.

Tetrahedron Letters published new progress about Alkynes, internal Role: SPN (Synthetic Preparation), PREP (Preparation). 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, COA of Formula: C7H4FNOS.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Wang, Guang-cheng; Wang, Jing; Li, Lu-yao; Chen, Shan; Peng, Ya-ping; Xie, Zhen-zhen; Chen, Ming; Deng, Bin; Li, Wen-biao published the artcile< Synthesis of N-aryl-2-aminobenzoxazoles from substituted benzoxazole-2-thiol and 2-chloro-N-arylacetamides in KOH-DMF system>, HPLC of Formula: 13451-78-0, the main research area is aminobenzoxazole aryl preparation; benzoxazole thiol arylacetamide chloro condensation.

A simple and novel method for the synthesis of N-aryl-2-aminobenzoxazoles I [R1 = H, 5-F, 6-Me, etc. ; R2 = 4-Cl, 2,4-di-Me, 4-OPh, etc.] from substituted benzoxazole-2-thiols II and 2-chloro-N-arylacetamides R2C6H4NHC(O)CH2Cl in KOH-DMF system has been developed. The present protocol provides an attractive approach to access various N-aryl-2-aminobenzoxazoles I in moderate to good yields without using transition metal catalyst under very mild reaction condition.

Heterocycles published new progress about Acetamides Role: RCT (Reactant), RACT (Reactant or Reagent). 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, HPLC of Formula: 13451-78-0.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Murray, Christopher W.; Berdini, Valerio; Buck, Ildiko M.; Carr, Maria E.; Cleasby, Anne; Coyle, Joseph E.; Curry, Jayne E.; Day, James E. H.; Day, Phillip J.; Hearn, Keisha; Iqbal, Aman; Lee, Lydia Y. W.; Martins, Vanessa; Mortenson, Paul N.; Munck, Joanne M.; Page, Lee W.; Patel, Sahil; Roomans, Susan; Smith, Kirsten; Tamanini, Emiliano; Saxty, Gordon published the artcile< Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors>, Safety of 5-Fluorobenzo[d]oxazole-2-thiol, the main research area is DDR inhibitor antitumor oral; back to front kinase design; discoidin domain receptor; fragment-based drug design.

The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We performed a fragment-based screen against DDR1 and identified fragments that bound either at the hinge or in the back pocket associated with the DFG-out conformation of the kinase. Modeling based on crystal structures of potent kinase inhibitors facilitated the “”back-to-front”” design of potent DDR1/2 inhibitors that incorporated one of the DFG-out fragments. Further optimization led to low nanomolar, orally bioavailable inhibitors that were selective for DDR1 and DDR2. The inhibitors were shown to potently inhibit DDR2 activity in cells but in contrast to unselective inhibitors such as dasatinib, they did not inhibit proliferation of mutant DDR2 lung SCC cell lines.

ACS Medicinal Chemistry Letters published new progress about Conformation. 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, Safety of 5-Fluorobenzo[d]oxazole-2-thiol.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Liu, Xing; Liu, Min; Xu, Wan; Zeng, Meng-Tian; Zhu, Hui; Chang, Cai-Zhu; Dong, Zhi-Bing published the artcile< An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water>, Recommanded Product: 5-Fluorobenzo[d]oxazole-2-thiol, the main research area is benzothiazole thiol green preparation; aminothiol tetramethylthiuram disulfide cyclization; benzoxazole thiol green preparation; aminoalc tetramethylthiuram disulfide cyclization; benzimidazoline thione green preparation; diamine tetramethylthiuram disulfide cyclization.

An efficient and practical method for the one-step synthesis of benzothiazole-2-thiols I [R = H, 5-Cl; X = S], benzoxazole-2-thiols I [R = H, 5-Me, 5-Br, etc.; X = O] and benzimidazoline-2-thiones such as II by cyclization of 2-aminothiophenols, 2-aminophenols, and 1,2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. This method was also used for the synthesis of 4,5-dihydro-thiazole-2-thiol, 4,5-dihydro-oxazole-2-thiol and 1,3-ethylenethiourea from their corresponding aliphatic amines and (TMTD). The features of this method included metal/ligand-free, excellent yield, short reaction time and broad substrate scope. The method provided a facile and convenient preparation of some potentially biol. active compounds

Green Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, Recommanded Product: 5-Fluorobenzo[d]oxazole-2-thiol.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Wan, Jin-Lin; Huang, Jing-Mei published the artcile< Bromide-Catalyzed Electrochemical Csp3-H Oxidation of Acetonitrile: Stereoselective Synthesis of Heteroaryl Vinyl Sulfides>, Computed Properties of 13451-78-0, the main research area is heteroaryl vinyl sulfide preparation electrochem diastereoselective; acetonitrile heteroaryl thiol oxidative cross coupling reaction bromide catalyst.

An electrochem. oxidative C-H/S-H cross-coupling reaction between acetonitrile and heteroaryl thiols e.g., 1,3-benzoxazole-2-thiol has been developed. Me4NBr is employed as a redox catalyst to oxidize both the Csp3-H of acetonitrile and S-H of heteroaryl thiols. Heteroaryl vinyl sulfides e.g., I were afforded under metal-free and oxidant-free reaction conditions in good yields and stereoselectivities with excellent functional group tolerance. The synthetic applicability of the electrochem. method was further highlighted by its easy scalability.

Advanced Synthesis & Catalysis published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, Computed Properties of 13451-78-0.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem