Tankam, Theeranon; Srisa, Jakkrit; Sukwattanasinitt, Mongkol; Wacharasindhu, Sumrit published the artcile< Microwave-Enhanced On-Water Amination of 2-Mercaptobenzoxazoles To Prepare 2-Aminobenzoxazoles>, Computed Properties of 13451-78-0, the main research area is microwave irradiation water amination mercaptobenzoxazole; aminobenzoxazole preparation green chem.
In this work, we developed a catalyst-free amination of 2-mercaptobenzoxazoles on water under microwave irradiation The product, 2-aminobenzoxazoles, was successfully produced via direct amination with various amines in moderate to high yields. The formal synthesis of Suvorexant, a medication for the treatment of insomnia, was accomplished using a developed amination process. The reaction was completed in an hour at 100-150° in a microwave reactor without the use of external catalyst or additive. Key benefits of this process include an on-water reaction, short reaction time, being scalable and catalyst-free, and use of 2-mercaptobenzoxazoles as an inexpensive starting material having low environmental impact in its preparation
Journal of Organic Chemistry published new progress about Amination. 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, Computed Properties of 13451-78-0.
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem