Month: November 2022

Chen, Jiang-Hua published the artcileTris(oxazoline)/copper-catalyzed coupling of alkynes with nitrones: a highly enantioselective access to β-lactams, Application of (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), the publication is Tetrahedron (2012), 68(25), 5042-5045, database is CAplus.

Chiral tris(oxazoline)/Cu(I) complexes are demonstrated as a type of efficient catalysts for the asym. Kinugasa reaction of terminal alkynes with C-arylnitrones, providing a highly enantio- and diastereoselective access to optically active β-lactams. For example, reacting PhCCH with PhN⁺(O^–):CHPh in the presence of CuOTf and tris(oxazoline) I gave β-lactam II as the major isomer.

Tetrahedron published new progress about 1239015-11-2. 1239015-11-2 belongs to benzoxazole, auxiliary class TOX Ligands, name is (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), and the molecular formula is C33H29N3O3, Application of (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole).

Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem

Zhou, You-Yun published the artcileHighly Enantioselective [3+3] Cycloaddition of Aromatic Azomethine Imines with Cyclopropanes Directed by π-π Stacking Interactions, Related Products of benzoxazole, the publication is Angewandte Chemie, International Edition (2013), 52(5), 1452-1456, database is CAplus and MEDLINE.

A new role of the ligands with sidearm group in a nickel catalyzed [3+3] cycloaddition reaction of isoquinoline azomethineimines with cyclopropanes, in which a prominent π-π stack-directing effect of the sidearm proved to be crucial to the stereochem. control.

Angewandte Chemie, International Edition published new progress about 1239015-11-2. 1239015-11-2 belongs to benzoxazole, auxiliary class TOX Ligands, name is (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), and the molecular formula is C27H39ClN2, Related Products of benzoxazole.

Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem

Ratni, Hasane published the artcileSpecific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy, Related Products of benzoxazole, the publication is Journal of Medicinal Chemistry (2016), 59(13), 6086-6100, database is CAplus and MEDLINE.

Spinal muscular atrophy (SMA) is the leading genetic cause of infant and toddler mortality, and there is currently no approved therapy available. SMA is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. These mutations or deletions result in low levels of functional SMN protein. SMN2, a paralogous gene to SMN1, undergoes alternative splicing and exclusion of exon 7, producing an unstable, truncated SMNΔ7 protein. Herein, we report the identification of a pyridopyrimidinone series of small mols. that modify the alternative splicing of SMN2, increasing the production of full-length SMN2 mRNA. Upon oral administration of our small mols., the levels of full-length SMN protein were restored in two mouse models of SMA. In-depth lead optimization in the pyridopyrimidinone series culminated in the selection of compound 3 (RG7800) (I), the first small mol. SMN2 splicing modifier to enter human clin. trials.

Journal of Medicinal Chemistry published new progress about 866332-15-2. 866332-15-2 belongs to benzoxazole, auxiliary class Boronic acid and ester,Benzooxazole,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (2-Methylbenzo[d]oxazol-6-yl)boronic acid, and the molecular formula is C8H8BNO3, Related Products of benzoxazole.

Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem

Cobo, Angel A. published the artcileCatalytic Asymmetric Synthesis of Cyclopentene-spirooxindoles Bearing Vinylsilanes Capable of Further Transformations, Recommanded Product: (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), the publication is Organic Letters (2019), 21(20), 8196-8200, database is CAplus and MEDLINE.

The authors report a Sc-catalyzed [3 + 2] annulation of alkylideneoxindoles with allenylsilanes for the enantioselective formation of cyclopentene-spirooxindoles containing vinylsilanes. Using a Sc(OTf)₂/PyBOX/BArF complex, the spiroannulation of allenylsilanes affords products with >94:6 dr and >90:10 er. The effect of the counterion and ligand to control selectivity is discussed. The transformation of the vinylsilane is demonstrated using cross-coupling, epoxidation, and Tamao-Fleming oxidation reactions. Competition experiments provide a comparison of nucleophilicity between allyl- and allenylsilanes.

Organic Letters published new progress about 1239015-11-2. 1239015-11-2 belongs to benzoxazole, auxiliary class TOX Ligands, name is (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), and the molecular formula is C33H29N3O3, Recommanded Product: (3aS,3a’S,3a”S,8aR,8a’R,8a”R)-2,2′,2″-(Propane-1,2,2-triyl)tris(8,8a-dihydro-3aH-indeno[1,2-d]oxazole).

Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem