Day: December 30, 2022

Microwave-assisted efficient one-step synthesis of amides from ketones and benzoxazoles from (2-hydroxyaryl) ketones with acetohydroxamic acid using sulfuric acid as the catalyst was written by Madabhushi, Sridhar;Chinthala, Narsaiah;Vangipuram, Venkata Sairam;Godala, Kondal Reddy;Jillella, Raveendra;Mallu, Kishore Kumar Reddy;Beeram, China Ramanaiah. And the article was included in Tetrahedron Letters in 2011.SDS of cas: 5676-58-4 This article mentions the following:

An efficient 1-step method for the synthesis of amides and benzoxazoles directly from ketones and 2-hydroxyaryl ketones, resp., by the reaction with AcNHOH using H₂SO₄ as catalyst was described. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.SDS of cas: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Long-Chained Acidic Ionic Liquids-Catalyzed Cyclization of 2-Substituted Aminoaromatics with β-Diketones: A Metal-Free Strategy to Construct Benzoazoles was written by Miao, Chengxia;Hou, Qin;Wen, Yating;Han, Feng;Li, Zhen;Yang, Lei;Xia, Chun-Gu. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.HPLC of Formula: 5676-58-4 This article mentions the following:

With long-chained acidic ionic liquids as catalysts, a metal-free, efficient, and universal strategy was developed to synthesize a series of benzoazole compounds through intermol. cyclization of 2-aminophenols/thiophenols/anilines with β-diketones. Compared with traditional ionic liquids, the long-chained ionic liquids with certain surfactivity exhibited better catalytic activities perhaps for micellar action and could be reused at least six times. A mechanism that involves condensation, nucleophilic addition, and C-C bond cleavage was proposed, and the imine compound was recognized as an important intermediate in the reaction. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Structure and photochemical properties of r-1, c-2, t-3, t-4-1, 3-bis[2-(5-R-benzoxazolyl)]-2,4-di(4-R’-phenyl)cyclobutane was written by Zhang, Wen-Qin;Zhuang, Jun-Peng;Li, Chun-Bao;Sun, Hao;Yuan, Xue-Ning. And the article was included in Chinese Journal of Chemistry in 2001.Formula: C9H9NO This article mentions the following:

R-1,c-2,t-3,t-4-1,3-Bis[2-(5-R-benzoxazolyl)]-2,4-di(4-R’-phenyl)cyclobutane (I; R,R’ given: H, H; Me,H; Me,OMe) was synthesized with high stereo-selectivity by the photodimerization of trans-1-[2-(5-R-benzoxazolyl)]-2-(4-R’-phenyl)ethene (II: R, R’ as above )in sulfuric acid. The structures of I were identified by elemental anal., IR, UV, ¹H NMR, ¹³C NMR and MS. The mol. and crystal structure of I(R=Me,R’=MeO) has been determined by X-ray diffraction method. The crystals of (C₃₄H₃₀N₂O₄ · 0.5C₂H₅OH) are monoclinic, space group P2₁/n with cell dimensions of a = 1.5416(3), b = 0.5625(1), c = 1.7875(4) nm, β = 91.56 (3)°, V = 1.550(1) nm³, Z = 2. The structure shows that the mol. is centrosym., which indicates that the dimerization process is a head-to-tail fashion. The selectivity of the photodimerization of substrates was enhanced by using acidic solvent and the reaction speed would be decreased when electron donating group was introduced in the 4-position of the Ph group. That the photodimerization is not affected by the presence of oxygen as well as its high stereoselectivity demonstrated that the reaction proceeded through an excited single state. It was also found that under irradiation of short wavelength UV, these dimers underwent photolysis completely to reproduce its trans-monomers, and then the new formed species changed into their cis-isomers through trans-cis isomerization. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Carbon-Carbon Bond Cleavage of Diynes through the Hydroamination with Transition Metal Catalysts was written by Shimada, Tomohiro;Yamamoto, Yoshinori. And the article was included in Journal of the American Chemical Society in 2003.Recommanded Product: 5676-58-4 This article mentions the following:

The C-C bond cleavage of terminal and internal diynes takes place readily in the presence of catalytic amounts of Ru₃(CO)₁₂ or Pd(NO₃)₂ and of 2-aminophenol, giving the corresponding benzoxazoles and ketones in good to high yields. Thus, reaction of 2-H₂NC₆H₄OH with RCCCCH [R = hexyl, decyl, cyclohexyl, Me₃C, PhCH₂CH₂, (Me₂CH)₃SiO(CH₂)₄, Cl(CH₂)₃] in MeOH containing Ru₃(CO)₁₂ and NH₄PF₆ gave mixtures of 2-methylbenzoxazole and the C-2 substituted benzoxazoles I in 58-98% yields in addition to acetone and RCOMe. The substituted aminophenols II (R¹ = 4-NO₂, 4-Cl, 4-Me, 4-MeO, 5-NO₂, 5-Me, 3-Me) reacted similarly with 1,3-decadiyne to give methylbenzoxazoles III and hexylbenzoxazoles IV. The two different modes of bond cleavage in these reactions are cleavage of an alkyne C-C triple bond and cleavage of the C-C single bond between the two alkyne groups. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Direct ortho-arylation of 2-arylbenzoxazoles via C-H activation was written by Yang, Fan;Wu, Yangjie;Zhu, Zhiwu;Zhang, Junli;Li, Yanan. And the article was included in Tetrahedron in 2008.Synthetic Route of C13H8BrNO This article mentions the following:

A new and highly regioselective arylation of 2-arylbenzoxazoles based on C-H activation has been developed. The results represent the first examples of palladium-catalyzed direct ortho-arylation of 2-arylbenzoxazoles and also provide a facile route for the synthesis of complicated structures containing arylated benzoxazoles moieties. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Synthetic Route of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Synthetic Route of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem