Month: December 2022

Madabhushi, Sridhar et al. published their research in Tetrahedron Letters in 2011 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.SDS of cas: 5676-58-4

Microwave-assisted efficient one-step synthesis of amides from ketones and benzoxazoles from (2-hydroxyaryl) ketones with acetohydroxamic acid using sulfuric acid as the catalyst was written by Madabhushi, Sridhar;Chinthala, Narsaiah;Vangipuram, Venkata Sairam;Godala, Kondal Reddy;Jillella, Raveendra;Mallu, Kishore Kumar Reddy;Beeram, China Ramanaiah. And the article was included in Tetrahedron Letters in 2011.SDS of cas: 5676-58-4 This article mentions the following:

An efficient 1-step method for the synthesis of amides and benzoxazoles directly from ketones and 2-hydroxyaryl ketones, resp., by the reaction with AcNHOH using H2SO4 as catalyst was described. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.SDS of cas: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Miao, Chengxia et al. published their research in ACS Sustainable Chemistry & Engineering in 2019 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.HPLC of Formula: 5676-58-4

Long-Chained Acidic Ionic Liquids-Catalyzed Cyclization of 2-Substituted Aminoaromatics with β-Diketones: A Metal-Free Strategy to Construct Benzoazoles was written by Miao, Chengxia;Hou, Qin;Wen, Yating;Han, Feng;Li, Zhen;Yang, Lei;Xia, Chun-Gu. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.HPLC of Formula: 5676-58-4 This article mentions the following:

With long-chained acidic ionic liquids as catalysts, a metal-free, efficient, and universal strategy was developed to synthesize a series of benzoazole compounds through intermol. cyclization of 2-aminophenols/thiophenols/anilines with β-diketones. Compared with traditional ionic liquids, the long-chained ionic liquids with certain surfactivity exhibited better catalytic activities perhaps for micellar action and could be reused at least six times. A mechanism that involves condensation, nucleophilic addition, and C-C bond cleavage was proposed, and the imine compound was recognized as an important intermediate in the reaction. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Zhang, Wen-Qin et al. published their research in Chinese Journal of Chemistry in 2001 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Formula: C9H9NO

Structure and photochemical properties of r-1, c-2, t-3, t-4-1, 3-bis[2-(5-R-benzoxazolyl)]-2,4-di(4-R’-phenyl)cyclobutane was written by Zhang, Wen-Qin;Zhuang, Jun-Peng;Li, Chun-Bao;Sun, Hao;Yuan, Xue-Ning. And the article was included in Chinese Journal of Chemistry in 2001.Formula: C9H9NO This article mentions the following:

R-1,c-2,t-3,t-4-1,3-Bis[2-(5-R-benzoxazolyl)]-2,4-di(4-R’-phenyl)cyclobutane (I; R,R’ given: H, H; Me,H; Me,OMe) was synthesized with high stereo-selectivity by the photodimerization of trans-1-[2-(5-R-benzoxazolyl)]-2-(4-R’-phenyl)ethene (II: R, R’ as above )in sulfuric acid. The structures of I were identified by elemental anal., IR, UV, 1H NMR, 13C NMR and MS. The mol. and crystal structure of I(R=Me,R’=MeO) has been determined by X-ray diffraction method. The crystals of (C34H30N2O4 · 0.5C2H5OH) are monoclinic, space group P21/n with cell dimensions of a = 1.5416(3), b = 0.5625(1), c = 1.7875(4) nm, β = 91.56 (3)°, V = 1.550(1) nm3, Z = 2. The structure shows that the mol. is centrosym., which indicates that the dimerization process is a head-to-tail fashion. The selectivity of the photodimerization of substrates was enhanced by using acidic solvent and the reaction speed would be decreased when electron donating group was introduced in the 4-position of the Ph group. That the photodimerization is not affected by the presence of oxygen as well as its high stereoselectivity demonstrated that the reaction proceeded through an excited single state. It was also found that under irradiation of short wavelength UV, these dimers underwent photolysis completely to reproduce its trans-monomers, and then the new formed species changed into their cis-isomers through trans-cis isomerization. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Shimada, Tomohiro et al. published their research in Journal of the American Chemical Society in 2003 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 5676-58-4

Carbon-Carbon Bond Cleavage of Diynes through the Hydroamination with Transition Metal Catalysts was written by Shimada, Tomohiro;Yamamoto, Yoshinori. And the article was included in Journal of the American Chemical Society in 2003.Recommanded Product: 5676-58-4 This article mentions the following:

The C-C bond cleavage of terminal and internal diynes takes place readily in the presence of catalytic amounts of Ru3(CO)12 or Pd(NO3)2 and of 2-aminophenol, giving the corresponding benzoxazoles and ketones in good to high yields. Thus, reaction of 2-H2NC6H4OH with RCCCCH [R = hexyl, decyl, cyclohexyl, Me3C, PhCH2CH2, (Me2CH)3SiO(CH2)4, Cl(CH2)3] in MeOH containing Ru3(CO)12 and NH4PF6 gave mixtures of 2-methylbenzoxazole and the C-2 substituted benzoxazoles I in 58-98% yields in addition to acetone and RCOMe. The substituted aminophenols II (R1 = 4-NO2, 4-Cl, 4-Me, 4-MeO, 5-NO2, 5-Me, 3-Me) reacted similarly with 1,3-decadiyne to give methylbenzoxazoles III and hexylbenzoxazoles IV. The two different modes of bond cleavage in these reactions are cleavage of an alkyne C-C triple bond and cleavage of the C-C single bond between the two alkyne groups. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Yang, Fan et al. published their research in Tetrahedron in 2008 | CAS: 99586-31-9

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Synthetic Route of C13H8BrNO

Direct ortho-arylation of 2-arylbenzoxazoles via C-H activation was written by Yang, Fan;Wu, Yangjie;Zhu, Zhiwu;Zhang, Junli;Li, Yanan. And the article was included in Tetrahedron in 2008.Synthetic Route of C13H8BrNO This article mentions the following:

A new and highly regioselective arylation of 2-arylbenzoxazoles based on C-H activation has been developed. The results represent the first examples of palladium-catalyzed direct ortho-arylation of 2-arylbenzoxazoles and also provide a facile route for the synthesis of complicated structures containing arylated benzoxazoles moieties. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Synthetic Route of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Synthetic Route of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Cheng, Hanchao’s team published research in Synlett in 2016-03-31 | CAS: 145026-07-9

Copper-Catalyzed Oxidative ¦Á-Ketoacylations of Sulfoximines with Aryl Methyl Ketones and Dioxygen as Terminal Oxidant. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

An efficient copper-catalyzed C-H/N-H bond functionalization for the synthesis ¦Á-keto-N-acyl sulfoximines from aryl Me ketones and NH-sulfoximines with mol. oxygen as terminal oxidant has been developed. E.g., under an atm. of dioxygen, CuBr in DMSO catalyzed the reaction of PhCOMe and PhSMe(O)(:NH) to give 74% PhCOCON:SMePh(O).

Copper-Catalyzed Oxidative ¦Á-Ketoacylations of Sulfoximines with Aryl Methyl Ketones and Dioxygen as Terminal Oxidant. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Aithagani, Sravan Kumar’s team published research in Organic Letters in 2015-11-20 | CAS: 50578-18-2

Metal-Free Approach for the Synthesis of N-Aryl Sulfoximines via Aryne Intermediate. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 145026-07-9

1-Iminotetrahydrothiophene 1-oxide (BD00963737) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A metal-free and operationally simple N-arylation of NH-sulfoximines with aryne precursors is reported. E.g., in presence of KF/18-crown-6 in THF, reaction of o-TMSC6H4OTf and PhSMe(:O):NH gave 72% PhSMe(:O):NPh. Transition metal-free reaction conditions and shorter reaction times are the highlights of the present method. The mild optimized condition was also suitable with enantiopure substrates.

Metal-Free Approach for the Synthesis of N-Aryl Sulfoximines via Aryne Intermediate. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 145026-07-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Tsao, Nai-Wen’s team published research in Journal of Wood Science in 2022-12-31 | CAS: 483-76-1

Composition analysis of exudates produced by conifers grown in Taiwan and their antifungal activity. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Exudates are involved in the defense mechanism of trees; they could work against insects or microorganisms through a phys. or chem. system. The main components of exudates are terpenoids. This study identified the main compounds of exudates from 13 conifers of Taiwan using gas chromatogram-mass spectrometry (GC-MS) and spectroscopic anal. The results revealed that the main volatiles were ¦Á-pinene, ¦Â-ocimene, ¦Â-pinene, sabinene, and caryophyllene. On the other hand, the main nonvolatile compounds were diterpenoids, which were classified into three skeletons (abietane-, labdane-, and pimarane-types). Among these, abietane-type presented in Pinaceae and in most of Cupressaceae; labdane-type presented in Pinaceae and in all of Cupressaceae and Araucariaceae; pimarane-type existed in both Pinaceae and Cupressaceae. Furthermore, the epigenetics of conifers anal. results by GC-MS and heteronuclear single quantum coherence (HSQC) of NMR (NMR) fingerprints were similar to traditional taxonomy classification; it indicated that exudates chemotaxonomy by using GC-MS and HSQC profiling is a useful technol. to classify the conifers. Besides, the exudates of Pinus elliottii, Pinus taiwanensis, Calocedrus macrolepis and Chamaecyparis formosensis possessed the strong antifungal activity. For white-rot fungus, Trametes versicolor, Pinus morrisonicola, Chamaecyparis obtusa, and Araucaria heterophylla exhibited the higher antifungal index. For brown-rot fungus, Laetiporus sulfureus, Pinus elliottii, Pinus morrisonicola, and Chamaecyparis formosensis revealed a good antifungal activity.

Composition analysis of exudates produced by conifers grown in Taiwan and their antifungal activity. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

He, Li-Li’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 2023-01-27 | CAS: 483-76-1

In vitro and in vivo antifungal activity of Cymbopogon citrates essential oils from different climate conditions against Botrytis cinerea. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Essential oils (EOs) are natural, volatile and aromatic substances extracted from some specific plants. EOs are the secondary metabolite of plants and usually varies with different plants and climate conditions, even in the same plant species but different climate conditions. The antifungal properties of EOs from medicinal as well as other edible plants have been recognized for very long time. Cymbopogon citratus oil, which is used as a food flavoring agent, possesses a broad spectrum of in vitro antifungal activities attributed to the high content of monoterpenoids such as ¦Á-Citral and ¦Â-Citral. In this study we focused on the changes of components of EOs in C. citratus growing in different climate conditions and their antifungal activities as well. The samples of C. citrates, fresh and dried, obtained from five different climate conditions in Southern and Southwestern China (Kunming, Jinghong, Fangchenggang, Zengcheng, Yuxi). The C. citrates EOs were extracted by the steam distillation method and analyzed by gas chromatog. coupled with mass spectrometry (GC-MS) and gas chromatog.-flame ionization detection (GC-FID). The results showed that the content of ¦Á-Citral was the highest in ten EOs. Fresh and dried C. citratus EOs accounted for 38.7% and 43.3% in Zengcheng, resp. However, fresh and dried C. citratus EOs accounted for 24.2% and 23.1% in Kunming. The effects of C. citratus EOs from different climate conditions against Botrytis cinerea were studied. All EOs had good inhibition against mycelial growth and spore germination of B. cinerea in vitro. At 15.63 mg/L, the inhibition of mycelial growth with the dried C. citrates EO from Zengcheng was significantly greater than that with the other EOs, with an inhibitory effect of 96.3%. It completely inhibited the mycelial growth of B. cinerea at 31.25 mg/L. Ten EOs also had good inhibitory effects on the rotten area of cherry tomatoes infected by B. cinerea in vivo. At 125 mg/L, the decay area of cherry tomatoes was reduced by more than 90%. The results indicated that the constituents in EOs of C. citrates are different from one growing place to another. The EOs of C. citrates may be considered as potential candidates to protect postharvest fruit from B. cinerea damage.

In vitro and in vivo antifungal activity of Cymbopogon citrates essential oils from different climate conditions against Botrytis cinerea. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Luz, Tassio Romulo Silva Araujo’s team published research in Experimental Parasitology in 2022-12-31 | CAS: 483-76-1

Seasonal variation in the chemical composition and larvicidal activity against Aedes aegypti L. of essential oils from Brazilian Amazon. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Arthropod-borne viral diseases are important public health threats in tropical countries. In the Americas, diseases such as Dengue, Zika, Chikungunya, Mayaro, and Yellow fever, which are mainly transmitted by Aedes aegypti L. are responsible for high rates of morbidity and mortality in the populations. The incidence of those viruses has increased in the last few years, due to the decrease of vector control programs, as well as, the resistance of this vector in front of many products that have been used in this proposal. Plant-based products such as essential oils are a promising alternative for Ae. aegypti control. In this context, the present work aims to investigate the seasonality effect on the larvicidal potential and safety of essential oils from 4 endemic plants of the Brazilian Amazon, as well as to verify their larvicidal activity and safety. The species were collected in the rainy and dry periods (Eugenia uniflora L., Lantana camara L., Ocimum basilicum L., Plectranthus neochilus Schlrt.). The essential oils were extracted by hydrodistillation and chem. composition was determined by gas chromatog. coupled to mass spectrometry. The larvicidal activity was performed according to the methodol. recommended by the World Health Organization. The safety of the oil use was evaluated against two non-target organisms: Artemia salina Leach and Danio rerio Hamilton Buchanan. Essential oils of E. uniflora, L. camara, O. basilicum, P. neochilus, presented as major compounds, in both collection periods, the substances Curzerene, Germacrene D, Me chavicol and, Caryophyllene, resp. However, showed a qual. and quant. variation of this composition All oils showed promising results against Ae. aegypti larvae with LC50 between 41.7 and 275.8 ¦Ìg/mL. They were efficient against Ae. aegypti but showed high toxicity to non-target organisms, requiring addnl. safety studies. Despite these results showing that those essential oils are not ideal larvicides because they presented toxicity to non-target organisms, bioprospection is a promising tool to help reduce the dissemination of arboviruses, and they can use in artificial breeders of Ae. aegypti larvae, where water will not be reused for human consumption or have other cohabiting organisms.

Seasonal variation in the chemical composition and larvicidal activity against Aedes aegypti L. of essential oils from Brazilian Amazon. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem