Day: January 4, 2023

Synthesis of diheteroarylacetylenes containing benzoxazole and pyridine groups was written by Liu, Jie;Zhuang, Jun-peng;Hao, Hai-jun;Zhang, Shu-guang;Niu, Jun-yu. And the article was included in Huaxue Shiji in 2015.Product Details of 5676-58-4 This article mentions the following:

Diheteroarylacetylenes containing benzoxazole and pryidine groups were synthesized from diheteroarylethenes in moderate yields by bromination with Br₂ in refluxing dichloromethane and then debromination with KOH-tBu in THF at room temperature Compared with the transition-metal-catalyzed methods, this procedure provided a metal-free, efficient and economical method with easily accessible starting materials form the synthesis of diheteroarylacetylenes. The UV and FL spectra were determined The photochem. determination showed that these diheteroarylethenes were photoinert to UV irradiation in organic solvent or in acidic aqueous solution In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Product Details of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Product Details of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Palladium catalyzed C_sp²-H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals was written by Seth, Kapileswar;Nautiyal, Manesh;Purohit, Priyank;Parikh, Naisargee;Chakraborti, Asit K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Name: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A novel strategy for direct aryl hydroxylation via Pd-catalyzed C_sp²-H activation through an unprecedented hydroxyl radical transfer from 1,4-dioxane, used as a solvent, is reported with bio relevant and sterically hindered heterocycles and various acyclic functionalities as versatile directing groups. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Name: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of triphenylamines via ligand-free selective ring-opening of benzoxazoles or benzothiazoles under superparamagnetic nanoparticle catalysis was written by Nguyen, Oanh T. K.;Nguyen, Long T.;Truong, Nhu K.;Nguyen, Viet D.;Nguyen, Anh T.;Le, Nhan T. H.;Le, Dung T.;Phan, Nam T. S.. And the article was included in RSC Advances in 2017.COA of Formula: C9H9NO This article mentions the following:

CuFe₂O₄ superparamagnetic nanoparticles were utilized as an effective recyclable heterogeneous catalyst for the synthesis of triphenylamines 2-HY-R-C₆H₃N(C₆H₄R¹)₂ (R = H, 5-Me; R¹ = H, 2-Me, 3-MeO, etc.; Y = S, O) via the ligand-free selective ring-opening reaction of benzoxazole, 2,5-dimethylbenzoxazole or benzothiazole with iodoarenes R¹C₆H₄X (X = I, Br, Cl). The nano CuFe₂O₄ demonstrated noticeably higher catalytic efficiency than a series of homogeneous catalysts and heterogeneous catalysts. It was possible to sep. the nano CuFe₂O₄ by using a magnet, and the recovered catalyst was reused many times while its activity could be maintained. This is the first example of heterogeneous catalysis for the transformation of benzoxazoles, and the transformation of benzothiazoles to triphenylamines has been reported. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Isolation and identification of new components in the ether-soluble portion of cigarette smoke condensate was written by Newell, Marjorie P.;Heckman, Robert A.;Moates, Robert F.;Green, Charles R.;Best, Freddie W.;Schumacher, J. N.. And the article was included in Tobacco Science in 1978.Synthetic Route of C9H9NO This article mentions the following:

Smoke condensates from 4 different 85-mm nonfiltered, uncased cigarettes smoked under standard conditions were partitioned between ether and water. The ether-soluble material, ∼60% of the total, was chromatographed on silicic acid with increasingly polar solvents to give 7 fractions. Further separation of the fractions by liquid-liquid partitions, column chromatog., and semi-preparative gas-liquid chromatog. led to the isolation and identification of 643 compounds, of which 173 were not previously reported as smoke components. Identification of individual isolates was accomplished by comparison of their IR, NMR, MS, and gas-liquid chromatog. retention times with those of authentic samples. The new isolates include 13 acids, 13 lactones, 2 aldehydes, 56 ketones, 4 alcs., 15 phenols, 19 N heterocyclics, 15 aliphatic hydrocarbons, 33 cyclic hydrocarbons, and 3 miscellaneous compounds A number of these new compounds are known to be in tobacco leaf. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Synthetic Route of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Synthetic Route of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Silica sulfuric acid catalyzed synthesis of benzoxazoles, benzimidazoles and oxazolo[4,5-b]pyridines under heterogeneous and solvent-free conditions was written by Mohammadpoor-Baltork, I.;Moghadam, M.;Tangestaninejad, S.;Mirkhani, V.;Zolfigol, M. A.;Hojati, S. F.. And the article was included in Journal of the Iranian Chemical Society in 2008.Reference of 5676-58-4 This article mentions the following:

A simple, rapid and efficient method for the preparation of benzoxazoles, benzimidazoles and oxazolo[4,5-b]pyridines from the reaction of orthoesters with o-aminophenols, o-phenylenediamine and 2-amino-3-hydroxypyridine in the presence of silica sulfuric acid under heterogeneous and solvent-free conditions is reported. The significant features of this method are short reaction times, high yields of the products, mild reaction conditions, solvent free reaction, cheapness, non-toxicity and reusability of the catalyst. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Reference of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Reference of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis and polymorphism of 2-(4′-nitrostyryl)benzoxazole and its derivatives was written by Shen, Yongjia;Han, Pingyang;Ren, Shengwu. And the article was included in Huadong Huagong Xueyuan Xuebao in 1990.Product Details of 5676-58-4 This article mentions the following:

2-(4′-Nitrostyryl)-benzoxazole and its 5-Me, nitro, acetamino, and Ph derivatives were synthesized. Their thermal behaviors and polymorphism were determined by DSC and x-ray diffraction. They have α, β modifications; the α-modification is thermo-unstable and can transform into the β-modification on heating. The ΔH_m, ΔS_m, and m.p. of the α-modification are lower than those of the β-modification. The melt of the α-modification is a supercooled liquid in contrast to the β-modification. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Product Details of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Product Details of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis and optical properties of some E,E-1,4-bis-[2′,2”-(benzoxazolylethenyl)]benzene and its substituted derivatives was written by Zhou, Yimin;Wu, Yanmin;Gao, Zhenheng. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 1989.Electric Literature of C9H9NO This article mentions the following:

The title compounds I (R and R¹ = H, halo, alkyl, Ph) were prepared by condensation of 1,4-diformylbenzene with 2-methylbenzoxazoles. IR, NMR, UV, fluorescence spectra as well as laser properties of I were reported. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Electric Literature of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Thallium in organic synthesis. 65. A novel synthesis of benzoxazoles from anilides was written by Taylor, Edward C.;Katz, Alan H.;Alvarado, Sergio I.;McKillop, Alexander. And the article was included in Journal of Organic Chemistry in 1986.HPLC of Formula: 5676-58-4 This article mentions the following:

Benzoxazoles I (R = Me, Ph, 4-ClC₆H₄; R¹ = H, Me, CHMeCO₂Me; R² = H, Me) are readily formed by photolysis of the regiospecifically ortho-thallated anilides II. This new methodol. was used for a synthesis of benoxaprofen (I, R = 4-ClC₆H₄, R¹ = CHMeCO₂H, R² = H) which exploits a second thallium-mediated reaction of 3-EtCOC₆H₄NHCOC₆H₄Cl-4 with HC(OMe)₃ for generation of the α-methylacetic acid substituent. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Reactions of phosphorus compounds. 36. Heterocyclic synthesis via methylenetriphenylphosphorane extrusion was written by Schweizer, Edward E.;DeVoe, Susan V.. And the article was included in Journal of Organic Chemistry in 1975.Reference of 5676-58-4 This article mentions the following:

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. A novel ylide elimination reaction gave 2-methylbenzothiazole (I), 2-methylquinazol-4-one (II), and 2,5-dimethylbenzoxazole (III) in greater than 62% yield. IV, V, and VI reacted with HCCCH2PPh3Br via the corresponding VII to give I, II, and III. The ylide formed from IV was not isolated. The reaction is a general heterocyclic synthesis. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Reference of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Reference of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles was written by Singh, Anoop S.;Mishra, Nidhi;Kumar, Dhananjay;Tiwari, Vinod K.. And the article was included in ACS Omega in 2017.HPLC of Formula: 99586-31-9 This article mentions the following:

A Lewis-acid-mediated ring cleavage of acylbenzotriazoles (RCOBt) followed by cyclization to corresponding benzoxazoles was achieved in good to excellent yields. The reaction was found consistent with the milligram to gram scale. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9HPLC of Formula: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.HPLC of Formula: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem