Day: January 5, 2023

Expeditious and efficient synthesis of benzoxazoles, benzothiazoles, benzimidazoles catalyzed by Ga(OTf)₃ under solvent-free conditions was written by Liu, Juyan;Liu, Qian;Xu, Wei;Wang, Weilu. And the article was included in Chinese Journal of Chemistry in 2011.Application In Synthesis of 2,5-Dimethylbenzoxazole This article mentions the following:

A new and efficient method for the synthesis of benzoxazoles, benzothiazoles, benzimidazoles by cyclocondensation of o-substituted aminoaroms. with ortho esters in the presence of catalytic amounts of Ga(OTf)₃ under solvent-free conditions is presented. The remarkable features of this new protocol are high conversion, very short reaction times, cleaner reaction profiles under solvent-free conditions, straightforward procedure, and use of a relatively non-toxic catalyst. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application In Synthesis of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Application In Synthesis of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis and reactions of 3,4-dihydro-2H-1,4-benzoxazine derivatives was written by Kotha, Sambasivarao;Bindra, Vandana;Kuki, Atsuo. And the article was included in Heterocycles in 1994.Electric Literature of C9H9NO This article mentions the following:

Several 3,4-dihydro-2H-1,4-benzoxazine derivatives, e.g., I (R = H, Me), were prepared from com. available benzoxazoles II by use of an efficient two step sequence. Thus, II were reduced to give ring opened aminophenols which were cyclized with BrCH₂CH₂Br to give I. Aryl functionalization reactions allowing access to further benzoxazine derivatives are also described. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Electric Literature of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Benzimidazoles and benzoxazoles via the nucleophilic addition of anilines to nitroalkanes was written by Aksenov, Alexander V.;Smirnov, Alexander N.;Aksenov, Nicolai A.;Bijieva, Asiyat S.;Aksenova, Inna V.;Rubin, Michael. And the article was included in Organic & Biomolecular Chemistry in 2015.Computed Properties of C9H9NO This article mentions the following:

PPA-induced umpolung triggers efficient nucleophilic addition of unactivated anilines to nitroalkanes to produce N-hydroxyimidamides. The latter undergo sequential acid-promoted cyclocondensation with ortho-hydroxy or ortho-amino moieties to afford benzoxazoles and benzimidazoles, e.g., I, resp. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Computed Properties of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Computed Properties of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

N-Acylbenzotriazole as Efficient Ligand in Copper-Catalyzed O-Arylation Leading to Diverse Benzoxazoles was written by Singh, Anoop S.;Singh, Mala;Mishra, Nidhi;Mishra, Snigdha;Agrahari, Anand K.;Tiwari, Vinod K.. And the article was included in ChemistrySelect in 2017.Category: benzoxazole This article mentions the following:

An establishment of (1H-benzo[d][1,2,3]triazol-1-yl)(2-methoxyphenyl)methanone as ligand was attained in intramol. C-O cross-coupling of N-(2-halophenyl)aryl/alkylamide derivatives XC₆H₄NHC(O)R [R = (CH₂)₁₀CH₃, C₆H₅, 2-H₃CC₆H₄, etc.; X = 2-Cl, 2-Br, 2,6-Cl₂-4-Br] to form 2-aryl/alkyl benzoxazole derivatives I (Y = H, 4-Cl-6-Br) using CuI/K₂CO₃ as catalytic system. Salient advantages associated with this pathway include easily available starting materials, cheap catalyst, highly stable ligand, wide substrate scope, smooth reaction, easy work-up and high product yield. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Category: benzoxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Metal free montmorillonite KSF clay catalyzed practical synthesis of benzoxazoles and benzothiazoles under aerobic conditions was written by Kummari, Vijaya Babu;Chiranjeevi, Kalavakuntla;Suman Kumar, Alleni;Aravind Kumar, Rathod;Yadav, Jhillu Singh. And the article was included in Synthetic Communications in 2019.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

An efficient method for the synthesis of benzoxazoles and benzothiazoles I [R = Cl, Me, NO₂, t-Bu; R¹ = Me, Et, i-Pr; X = O, S] via montmorillonite KSF clay catalyzed condensation reaction of β-diketones and 2-aminophenols or 2-aminothiophenols resp. was reported. The efficiency of the reaction reflected from the wide substrate scope with electronic differentiation on aryls. The reaction was metal free and proceeded without the exclusion of air or moisture, and further the catalyst could be recycled up to 3-5 catalytic cycles. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Name: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Thermochemistry of 2-methylbenzoxazole and 2,5-dimethylbenzoxazole: an experimental and computational study was written by Silva, Ana L. R.;Cimas, Alvaro;Ribeiro da Silva, Maria D. M. C.. And the article was included in Structural Chemistry in 2013.Formula: C9H9NO This article mentions the following:

The standard (p^o = 0.1 MPa) molar energies of combustion of 2-methylbenzoxazole and 2,5-dimethylbenzoxazole were measured by static-bomb combustion calorimetry. The standard molar enthalpies of vaporization, at T = 298.15 K, were obtained from high-temperature Calvet microcalorimetry. The exptl. results enable the calculation of the standard molar enthalpies of formation in the gaseous state, at T = 298.15 K, for both compounds, with the results discussed in terms of structural and energetic contributions. The theor. estimated gas-phase enthalpies of formation were calculated from high-level ab initio MO calculations at the G3(MP2)//B3LYP level of theory. The computed values compare very well with the exptl. results obtained in this work and show that the 2,5-dimethylbenzoxazole is enthalpically the most stable compound Furthermore, this composite approach was also used to obtain information about the gas-phase basicities, proton and electron affinities, and adiabatic ionization enthalpies. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Facile synthesis of 3-arylpyridine derivatives by palladacycle-catalyzed Stille cross-coupling reaction was written by Ma, Gaizhi;Leng, Yuting;Wu, Yusheng;Wu, Yangjie. And the article was included in Tetrahedron in 2013.Electric Literature of C13H8BrNO This article mentions the following:

The Stille cross-coupling reaction of a variety of aryl halides (X = Cl, Br, I) with 3- or 2-(trialkylstannyl)pyridines was catalyzed by cyclopalladated ferrocenylimine. This reaction allows formation of arylpyridine derivatives in moderate to excellent yields. Functional groups on the aryl halides, such as amino, hydroxyl, keto, and formyl, are tolerated and the reactions with arylbenzoxazole substrates also proceeded well. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Electric Literature of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Electric Literature of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1,3-Dibromo-5,5-dimethylhydantoin as an efficient homogeneous catalyst for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines was written by Hojati, Seyedeh Fatemeh;Maleki, Behrooz;Beykzadeh, Zahra. And the article was included in Monatshefte fuer Chemie in 2011.HPLC of Formula: 5676-58-4 This article mentions the following:

A simple and highly efficient method for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines was described. Condensation of orthoesters with o-substituted anilines or 2-amino-3-hydroxypyridine was performed in the presence of catalytic amounts of com. available, inexpensive, and moisture-stable 1,3-dibromo-5,5-dimethylhydantoin under solvent-free conditions. The corresponding heterocycles were obtained in good to excellent yields. The main advantages of the present procedure are mild reaction conditions, short reaction times, high yields of products, easy work-up, and absence of solvent. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

ZrOCl₂.8H₂O as an efficient, environmentally friendly and reusable catalyst for synthesis of benzoxazoles, benzothiazoles, benzimidazoles and oxazolo[4,5-b]pyridines under solvent-free conditions was written by Mohammadpoor-Baltork, Iraj;Khosropour, Ahmad Reza;Hojati, Seyedeh Fatemeh. And the article was included in Catalysis Communications in 2007.Electric Literature of C9H9NO This article mentions the following:

A new and efficient method for the preparation of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines from reactions of orthoesters with o-substituted aminoaroms. and 2-amino-3-hydroxypyridine in the presence of catalytic amounts of the moisture stable, inexpensive ZrOCl₂.8H₂O under solvent-free conditions was presented. This new protocol had the advantages of easy availability, easy handling, stability, reusability and eco-friendly of the catalyst, high yields, very short reaction times, solvent-free reaction conditions, simple exptl. and work-up procedure. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Electric Literature of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem