Day: January 5, 2023

Cyclopalladated ferrocenylimine catalyzed ortho-arylation of sp² C-H bond substrates containing the directing group was written by Li, Ya-Nan;Yang, Fan;Wu, Yang-Jie. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2008.Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A novel and efficient catalytic system for ortho-arylation of sp² C-H bond substrates containing the directing group using cyclopalladated ferrocenylimine as catalyst was developed. The arylation showed high regioselectivity and only occurred on the less sterically hindered ortho-C-H bond. The reaction could be compatible to diverse functional groups such as CH₃, CH₃O, and CH₃CO, as well as Br and Cl substituents, which would permit to be functionalized further to construct new compounds with more complicated structures. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Biochemical and Structural Evaluation of Highly Selective 2-Arylbenzoxazole-Based Transthyretin Amyloidogenesis Inhibitors was written by Johnson, Steven M.;Connelly, Stephen;Wilson, Ian A.;Kelly, Jeffery W.. And the article was included in Journal of Medicinal Chemistry in 2008.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

To develop potent transthyretin (TTR) amyloidogenesis inhibitors that also display high binding selectivity in blood, it proves useful to systematically optimize each of the three substructural elements that comprise a typical inhibitor: the two aryl rings and the linker joining them. In the first study, described herein, structural modifications to one aryl ring were evaluated by screening a library of 2-arylbenzoxazoles bearing thyroid hormone-like aryl substituents on the 2-aryl ring. Several potent and highly selective amyloidogenesis inhibitors were identified that exhibit minimal thyroid hormone nuclear receptor and COX-1 binding. High resolution crystal structures (1.3-1.5 A) of three inhibitors (I, II, and III) in complex with TTR were obtained to characterize their binding orientation. Collectively, the results demonstrate that thyroid hormone-like substitution patterns on one aryl ring lead to potent and highly selective TTR amyloidogenesis inhibitors that lack undesirable thyroid hormone receptor or COX-1 binding. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Studies on the synthesis and photochemical properties of chain linked bisheteroarylethenes was written by Zhang, Wen-Qin;Wang, Shu-Li;Zhao, Hai-Tao;Zhuang, Jun-Peng;Sun, Hao;Zhao, Shu-Na;Zheng, Yan;Li, Chun-Bao. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2000.Quality Control of 2,5-Dimethylbenzoxazole This article mentions the following:

1,3-Bis[trans-4-[2-[2-(5-methylbenzoxazolyl)]ethenyl]phenoxy]propane, 1,4-Bis[trans-4-[2-[2-(5-methylbenzoxazolyl)]ethenyl]phenoxy]butane, 1,6-Bis[trans-4-[2-[2-(5-methylbenzoxazolyl)]ethenyl]phenoxy]hexane, and 2,2′-bis[trans-4-[2-[2-(5-methylbenzoxazolyl)]ethenyl]phenoxy]ethyl ether were synthesized. Their structures were identified by elemental anal., IR, UV, ¹H NMR, ¹³C NMR and MS. The UV spectra were used to illustrate the change of title compounds under the irradiation of high-pressure-mercury-lamp. It was found that these compounds undergo two kinds of reactions, the trans-cis isomerization and intramol. photodimerization. The former is fast and reversible, and the latter is slow and irreversible. The speed of intramol. photodimerization will increase with increasing the length of the carbon chain between the two 2-[[2-(5-methylbenzoxazolyl)]ethenyl]phenyl group. The fact that the photodimerization is not affected by oxygen shows that the reaction proceeds through an excited singlet state. It is also revealed that title compounds undergo [2+2] photolysis easily when irradiated under short UV light. That the intramol. photodimerization and photolysis of these compounds can repeat many times indicate that these compounds have a high photostability. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Quality Control of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Quality Control of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Tungstate sulfuric acid as an efficient catalyst for the synthesis of benzoxazoles and benzothiazoles under solvent-free conditions was written by Farahi, Mahnaz;Karami, Bahador;Azari, Masume. And the article was included in Comptes Rendus Chimie in 2013.Formula: C9H9NO This article mentions the following:

Tungstate sulfuric acid (TSA) was found to be an efficient and reusable catalyst for the synthesis of benzoxazole and benzothiazole derivatives via reactions of ortho esters with o-aminophenols or o-aminothiophenols in high yields. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Palladium (II) Complex Supported on Magnetic Nanoparticles Modified with Phenanthroline: A Highly Active Reusable Nanocatalyst for the Synthesis of Benzoxazoles, Benzothiazoles and Cyanation of Aryl Halides was written by Cai, Yuan;Yuan, Hailong;Gao, Qiang;Wu, Lili;Xue, Lijun;Feng, Nengjie;Sun, Yuan. And the article was included in Catalysis Letters.Application of 99586-31-9 This article mentions the following:

A well dispersed magnetically separable palladium complex (MNPs-phenanthroline-Pd) has been synthesized via the immobilization of palladium (II) complex on the surface of silica-coated magnetic nanoparticles modified with phenanthroline ligand. The SEM and TEM images of MNPs-phenanthroline-Pd at different magnification show that the catalyst is formed of nanometer-sized particles. The MNPs-phenanthroline-Pd nanocomposite was found to be an efficient catalyst for the synthesis of benzoxazoles, benzothiazoles and cyanation of aryl halides. The high efficiency and the ability to be recovered and reused for at least up to seven consecutive runs are some superior properties of the catalyst. SEM images of reused catalyst confirmed that there was no significant change in the morphol. and dispersion of the particles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Application of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem