Day: January 30, 2023

Simple and efficient one-pot synthesis of 2-substituted benzoxazole and benzothiazole was written by Patil, Sachin S.;Bobade, Vivek D.. And the article was included in Synthetic Communications in 2010.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

2-Substituted benzoxazole and benzothiazole were synthesized from condensation of aldehyde and 2-aminophenol or 2-aminothiophenol via a one-pot process using di-Et bromophoshonate and tert-Bu hypochlorite. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Name: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Copper-Mediated Synthesis of Substituted 2-Aryl-N-benzylbenzimidazoles and 2-Arylbenzoxazoles via C-H Functionalization/C-N/C-O Bond Formation was written by Guru, Murali Mohan;Ali, Ashif Md.;Punniyamurthy, Tharmalingam. And the article was included in Journal of Organic Chemistry in 2011.Recommanded Product: 99586-31-9 This article mentions the following:

An efficient method for the transformation of N-benzyl bisarylhydrazones, e.g., I, and bisaryloxime ethers, e.g., II, to functionalized 2-aryl-N-benzylbenzimidazoles, e.g., III, and 2-arylbenzoxazoles, e.g., IV, is described. The protocol involves a copper(II)-mediated cascade C-H functionalization/C-N/C-O bond formation under neutral conditions. Substrates having either electron-donating or electron-withdrawing substituents undergo the cyclization to afford the target heterocycles at moderate temperature In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Recommanded Product: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Infrared behavior of heterocycles (bases for photographic sensitizers) according to the nature of the heteroatom and the substituents was written by Bassignana, P.;Cogrossi, C.;Gandino, M.. And the article was included in Chimie et Industrie (Paris) in 1963.Electric Literature of C9H9NO This article mentions the following:

A number of instances are given in which IR frequency shifts of the out-of-plane CH deformation of a 5-membered heterocyclic ring can be correlated with the electronegativity of the heteroatom. The successive introduction of functional groups R, electron donors and acceptors, into position 5 or 6 in the aromatic ring produces out-of-plane vibration displacements of the CH adjacent to the substituted C. A decrease of ν of the nearby CH groups corresponds to a decrease of electronegativity of the heteroatom. This is true of benzo- and 2-methylbenzo derivatives Changes occur when a 2nd heteroatom is introduced in a β position to that of the 1st hetero-atoms (oxazole, thiazole, selenazole). The vibrations then are influenced by the 2 heteroatoms. In keeping the same heteroatom (N) in the 3-position in the heterocyclic nucleus, and in changing the heteroatom in position 1, it is not possible to trace a straight line on a plot of frequency vs. electronegativity according to the Pauling electronegativity series. In effect, a broken line occurs, to which corresponds the min. value of the frequency of out-of-plane CH deformation when the 2nd heteroatom is N. An increase in CH frequency deformation with a decrease in-electronegativity is established (except when the 2nd heteroatom is N). In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Electric Literature of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Cobalt-catalyzed intramolecular C-N and C-O cross-coupling reactions: synthesis of benzimidazoles and benzoxazoles was written by Saha, Prasenjit;Ali, Ashif Md.;Ghosh, Pokhraj;Punniyamurthy, Tharmalingam. And the article was included in Organic & Biomolecular Chemistry in 2010.Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

Cobalt(II)-complex catalyzes efficiently the intramol. C-N and C-O cross-couplings of Z-N’-(2-halophenyl)-N-phenylamidines, e.g. I, and N-(2-bromophenyl)benzamides, e.g. II, to afford the corresponding substituted benzimidazoles and benzoxazoles, e.g. III [X = NPh, O], in the presence of K₂CO₃ at moderate temperature The protocol is general, air stable and affords the products selectively in moderate to high yield. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of benzoxazoles by an efficient Ullmann-type intramolecular C_(aryl)-O bond-forming coupling cyclization with a BINAM-copper(II) catalyst was written by Naidu, Ajay B.;Sekar, Govindasamy. And the article was included in Synthesis in 2010.Formula: C13H8BrNO This article mentions the following:

A wide range of 2-arylbenzoxazoles were synthesized from the corresponding N-(2-iodophenyl)benzamides through intramol. C_(aryl)-O bond formation via Ullmann-type coupling cyclization in the presence of a catalytic amount of an easily available BINAM-copper(II) complex under very mild reaction conditions (82 °C). Less reactive bromo and chloro analogs of the N-(2-halophenyl)benzamides were also successfully cyclized to produce benzoxazoles, without increasing the catalyst loading. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Formula: C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Nano CeO2 as a new green and recyclable catalyst for the synthesis of 2-aryl Benzoxazole was written by Baghernejad, Bita;Samaie, Reyhaneh. And the article was included in Asian Journal of Nanoscience and Materials in 2021.Category: benzoxazole This article mentions the following:

In this research, a simple method for the synthesis of high-efficiency 2-aryl benzoxazoles I [R¹ = H, Me, Cl; R² = H. Me, Cl] via reaction of aminophenols and aldehyde derivatives under solvent-free conditions in the presence of a catalytic amount of nano-CeO₂ was presented. Some of these derivatives I have anticoagulant, antispasmodic, diuretic, anti-cancer and anti-anaphylactin properties. The results revealed that this synthetic reaction was very simple and benzoxazole derivatives produced with good yields compared to other studies. Mild conditions, high speed and short reaction time, simplicity of product separation process, high efficiency and purity of synthesized derivatives were the advantages of the proposed method. Highest efficiency (95%) in a short time (15 min) was obtained in this study, which was very important compared to other previous methods presented. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Category: benzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Silica supported fluoroboric acid: an efficient and reusable heterogeneous catalyst for facile synthesis of 2-aliphatic benzothiazoles, benzoxazoles, benzimidazoles and imidazo[4,5-b]pyridines was written by Patil, Abasaheb V.;Bandgar, Babasaheb P.;Lee, Soo-Hyoung. And the article was included in Bulletin of the Korean Chemical Society in 2010.Category: benzoxazole This article mentions the following:

2-Substituted benzothiazoles, benzoxazoles, benzimidazoles and imidazo[4,5-b]pyridines were prepared by cyclization of aminophenols, aminothiophenols, phenylenediamines and a pyridinediamine with ortho esters using silica-supported tetrafluoroboric acid a catalyst. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Category: benzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

TiO₂-ZrO₂ composite: Synthesis, characterization and application as a facile, expeditious and recyclable catalyst for the synthesis of 2-aryl substituted benzoxazole derivatives was written by Patil, Mahadeo R.;Bhanushali, Jayesh T.;Nagaraja, Bhari Mallanna;Keri, Rangappa S.. And the article was included in Comptes Rendus Chimie in 2018.HPLC of Formula: 99586-31-9 This article mentions the following:

The activity of an efficient mesoporous TiO₂-ZrO₂ composite catalyst for the synthesis of 2-aryl substituted benzoxazole derivatives using 2-aminophenol and substituted benzaldehydes/heterocyclic aldehydes at moderate temperature was studied. The catalyst was prepared by a co-precipitation method and characterized by X-ray diffraction, BET surface area and SEM. The effect of temperature, solvents and catalyst concentration on the synthesis of benzoxazole derivatives was systematically investigated. Short reaction times, green-reaction profiles, good to excellent yields, reliable cost efficiency, simple workup conditions and reusability of an eco-friendly catalyst were the noteworthy highlights of the reported method. The catalyst could be easily recovered and reused several times without any significant loss in the yield. The use of the present catalytic system to mediate the title chem. synthesis in a synthetic operation was important for the development of new atom-economic strategies and this was efficient in building complex structures from simple starting materials in an environmentally benign fashion. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9HPLC of Formula: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.HPLC of Formula: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A Green and Efficient Protocol for the Synthesis of Quinoxaline, Benzoxazole and Benzimidazole Derivatives Using Heteropolyanion-Based Ionic Liquids: As a Recyclable Solid Catalyst was written by Vahdat, Seyed Mohammad;Baghery, Saeed. And the article was included in Combinatorial Chemistry & High Throughput Screening in 2013.Application In Synthesis of 2,5-Dimethylbenzoxazole This article mentions the following:

In this paper, the authors introduce two non-conventional ionic liquid compounds which are composed of propane sulfonate functionalized organic cations and heteropoly anions as green solid acid catalysts for the highly efficient and green synthesis of 2,3-disubstituted quinoxaline derivatives These ionic liquids are in the solid state at room temperature and the synthesis is carried out by a one-pot condensation reaction of various phenylenediamine derivatives with 1,2-diketone derivatives Benzoxazole and benzimidazole derivatives were also synthesized by these novel catalysts by a one-pot condensation from reaction orthoester with o-aminophenol (synthesis of benzoxazole derivatives) and phenylenediamine (synthesis of benzimidazole derivatives). All experiments successfully resulted in the desired products. The described novel synthesis method has several advantages of easy handling of reactants, mild reaction conditions, high yields, short reaction times, simplicity and easy workup compared to the traditional method of synthesis. The synthesis of the target compounds was achieved using as catalysts 1-methyl-3-(3-sulfopropyl)-1H-imidazolium tetracosa-μ-oxododecaoxo[μ₁₂-[phosphato(3-)-κO:κO:κO:κO‘:κO‘:κO‘:κO”:κO”:κO”:κO”’:κO”’:κO”’]]dodecatungstate(3-) (3:1) [1-methyl-3-(3-sulfopropyl)-1H-imidazolium tungstophosphate [PW₁₂O₄₀^3-]] and N,N,N-triethyl-3-sulfo-1-propanaminium tetracosa-μ-oxododecaoxo[μ₁₂-[phosphato(3-)-κO:κO:κO:κO‘:κO‘:κO‘:κO”:κO”:κO”:κO”’:κO”’:κO”’]]dodecatungstate(3-) (3:1) [1-methyl-3-sulfo-1-propanaminium tungstophosphate [PW₁₂O₄₀^3-]] as catalysts. The title compounds thus formed included 2,3-diphenylquinoxaline derivatives, 1H-benzimidazole derivatives, benzoxazole derivatives, dibenzo[a,c]phenazine, acenaphtho[1,2-b]quinoxaline, 2,5-dimethylbenzoxazole. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application In Synthesis of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Application In Synthesis of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem