Day: January 30, 2023

Palladium-Catalyzed Regioselective C-H Bond Arylations of Benzoxazoles and Benzothiazoles at the C7 Position was written by Abdellaoui, Fatma;Youssef, Chiraz;Ben Ammar, Hamed;Roisnel, Thierry;Soule, Jean-Francois;Doucet, Henri. And the article was included in ACS Catalysis in 2016.Formula: C9H9NO This article mentions the following:

We report herein, a very simple catalytic system for the direct arylation of benzoxazole and benzothiazole derivatives at C7 position, namely, phosphine-free PdCl₂ associated with PivOK in NMP at 150°. (Thio)phenoxy chelation-assisted Pd-catalyzed C-H bond cleavage, from an opened intermediate, was proposed to explain this unique regioselectivity. This reaction allows the synthesis of 2-amino-6-arylphenols through the ring opening of the benzoxazole. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Cu-catalysed transamidation of unactivated aliphatic amides was written by Kumar, Vishal;Dhawan, Sanjeev;Bala, Renu;Mohite, Sachin Balaso;Singh, Parvesh;Karpoormath, Rajshekhar. And the article was included in Organic & Biomolecular Chemistry in 2022.COA of Formula: C9H9NO This article mentions the following:

Direct transamidation was gaining prominence as a ground-breaking technique that generates a wide variety of amides without the requirement of acid-amine coupling or other intermediate steps. However, transamidation of unactivated aliphatic amides, on the other hand, was a long-standing issue in comparison to transamidation of activated amides. Herein, a transamidation approach of an unactivated aliphatic amide using a copper catalyst and chlorotrimethylsilane as an additive was reprted. In addition, used transamidation as a tool for selective N-C(O) cleavage and O-C(O) formation to synthesize 2-substituted benzoxazoles and benzothiazoles. The reactions were carried out without using any solvents and offered wide substitution scope. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chemical composition and anti-inflammatory activity of the essential oil of Nigerian Psorospermum tenuifolium (Hook. F.) was written by Zubair, M. F.;Oladosu, I. A.;Olawore, N. O.;Fakunle, C. O.. And the article was included in International Journal of Essential Oil Therapeutics in 2009.Application In Synthesis of 2,5-Dimethylbenzoxazole This article mentions the following:

The chem. composition of the essential oils obtained by hydrodistillation from the leaves and roots of Psorospermum tenuifolium collected from North Central Nigeria were analyzed by GC and GC/MS. Twenty-nine compounds representing 93.54% of the leaf essential oil and thirteen compounds representing 83.63% of the root essential oil were determined The two types of oils were differentiated according to their main components. The major constituents of the leaf oil were linalool, α-terpineol,β-caryophyllene, 3-carene and α-gurjunene. The root oil was predominantly monoterpenes that included α-pinene, β-pinene, limonene and myrcene. The leaf essential oil was subjected to anti-inflammatory assay due to its higher number of compounds At 5.0 and 2.5 mg dose levels, the oil exhibited significant anti-inflammatory activity with an edema reduction of 92.3% and 76.9% resp., which was more effective than that demonstrated by a 0.25 mg dose of indomethacin. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application In Synthesis of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Application In Synthesis of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Nuclear magnetic resonance study of the benzoxazole derivatives was written by Okuda, Hisashi;Nagai, Makoto. And the article was included in Bulletin of the Chemical Society of Japan in 1967.HPLC of Formula: 5676-58-4 This article mentions the following:

The proton N.M.R. spectra of 2,5-dimethylbenzoxazole, 2,5,7-trimethylbenzoxazole, 2,5,6-trimethylbenzoxazole, 2 methyl-5-chlorobenzoxazole, and 2,4,5-trimethylbenzoxazole are recorded in CCl4 (or CDCl3) and in CF3COOH. In neutral solution, the chem. shifts are interpreted in terms of π-electronic charge ds., magnetic anisotropy of the O and N heteroatoms, and the elec. field effect. Protonation of the N heteroatom in acid solution shifts all of the protons to lower field. To account for the linear dependence of the chem. shifts, corrected for the elec. and anisotropy contributions, with calculated π-electron ds. a proportionality constant of 3.37 ppm./electron is needed. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem