Month: January 2023

Palladium-Catalyzed Regioselective C-H Bond Arylations of Benzoxazoles and Benzothiazoles at the C7 Position was written by Abdellaoui, Fatma;Youssef, Chiraz;Ben Ammar, Hamed;Roisnel, Thierry;Soule, Jean-Francois;Doucet, Henri. And the article was included in ACS Catalysis in 2016.Formula: C9H9NO This article mentions the following:

We report herein, a very simple catalytic system for the direct arylation of benzoxazole and benzothiazole derivatives at C7 position, namely, phosphine-free PdCl₂ associated with PivOK in NMP at 150°. (Thio)phenoxy chelation-assisted Pd-catalyzed C-H bond cleavage, from an opened intermediate, was proposed to explain this unique regioselectivity. This reaction allows the synthesis of 2-amino-6-arylphenols through the ring opening of the benzoxazole. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Cu-catalysed transamidation of unactivated aliphatic amides was written by Kumar, Vishal;Dhawan, Sanjeev;Bala, Renu;Mohite, Sachin Balaso;Singh, Parvesh;Karpoormath, Rajshekhar. And the article was included in Organic & Biomolecular Chemistry in 2022.COA of Formula: C9H9NO This article mentions the following:

Direct transamidation was gaining prominence as a ground-breaking technique that generates a wide variety of amides without the requirement of acid-amine coupling or other intermediate steps. However, transamidation of unactivated aliphatic amides, on the other hand, was a long-standing issue in comparison to transamidation of activated amides. Herein, a transamidation approach of an unactivated aliphatic amide using a copper catalyst and chlorotrimethylsilane as an additive was reprted. In addition, used transamidation as a tool for selective N-C(O) cleavage and O-C(O) formation to synthesize 2-substituted benzoxazoles and benzothiazoles. The reactions were carried out without using any solvents and offered wide substitution scope. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chemical composition and anti-inflammatory activity of the essential oil of Nigerian Psorospermum tenuifolium (Hook. F.) was written by Zubair, M. F.;Oladosu, I. A.;Olawore, N. O.;Fakunle, C. O.. And the article was included in International Journal of Essential Oil Therapeutics in 2009.Application In Synthesis of 2,5-Dimethylbenzoxazole This article mentions the following:

The chem. composition of the essential oils obtained by hydrodistillation from the leaves and roots of Psorospermum tenuifolium collected from North Central Nigeria were analyzed by GC and GC/MS. Twenty-nine compounds representing 93.54% of the leaf essential oil and thirteen compounds representing 83.63% of the root essential oil were determined The two types of oils were differentiated according to their main components. The major constituents of the leaf oil were linalool, α-terpineol,β-caryophyllene, 3-carene and α-gurjunene. The root oil was predominantly monoterpenes that included α-pinene, β-pinene, limonene and myrcene. The leaf essential oil was subjected to anti-inflammatory assay due to its higher number of compounds At 5.0 and 2.5 mg dose levels, the oil exhibited significant anti-inflammatory activity with an edema reduction of 92.3% and 76.9% resp., which was more effective than that demonstrated by a 0.25 mg dose of indomethacin. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application In Synthesis of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Application In Synthesis of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Nuclear magnetic resonance study of the benzoxazole derivatives was written by Okuda, Hisashi;Nagai, Makoto. And the article was included in Bulletin of the Chemical Society of Japan in 1967.HPLC of Formula: 5676-58-4 This article mentions the following:

The proton N.M.R. spectra of 2,5-dimethylbenzoxazole, 2,5,7-trimethylbenzoxazole, 2,5,6-trimethylbenzoxazole, 2 methyl-5-chlorobenzoxazole, and 2,4,5-trimethylbenzoxazole are recorded in CCl4 (or CDCl3) and in CF3COOH. In neutral solution, the chem. shifts are interpreted in terms of π-electronic charge ds., magnetic anisotropy of the O and N heteroatoms, and the elec. field effect. Protonation of the N heteroatom in acid solution shifts all of the protons to lower field. To account for the linear dependence of the chem. shifts, corrected for the elec. and anisotropy contributions, with calculated π-electron ds. a proportionality constant of 3.37 ppm./electron is needed. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mild and efficient synthesis of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines catalyzed by Bi(III) salts under solvent-free conditions was written by Mohammadpoor-Baltork, Iraj;Khosropour, Ahmad R.;Hojati, Seyedeh F.. And the article was included in Monatshefte fuer Chemie in 2007.Computed Properties of C9H9NO This article mentions the following:

A series of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines was efficiently synthesized from the reactions of o-aminophenols, o-aminothiophenol, o-phenylenediamines, and 2-amino-3-hydroxypyridine with orthoesters in the presence of catalytic amounts of Bi(III) salts, such as Bi(TFA)₃, Bi(OTf)₃, and BiOClO₄ · xH₂O under solvent-free conditions. The remarkable features of this new protocol are high conversion, very short reaction times, cleaner reaction profiles under solvent-free conditions, straightforward procedure, and use of relatively non-toxic catalysts. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Computed Properties of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Computed Properties of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Deep eutectic solvent-catalyzed arylation of benzoxazoles with aromatic aldehydes was written by Tran, Phuong Hoang;Thi Hang, Anh-Hung. And the article was included in RSC Advances in 2018.SDS of cas: 99586-31-9 This article mentions the following:

A novel and efficient methodol. for the arylation of benzoxazoles with aromatic aldehydes catalyzed by deep eutectic solvent has been developed. The reaction smoothly proceeded with a wide range of substrates to give the desired products in high yields within short reaction time. Deep eutectic solvents are easily recovered and reused without significant loss of catalytic activity. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9SDS of cas: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.SDS of cas: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Acid Catalyzed Direct-Amidation-Dehydrocyclization of 2-Hydroxy-acetophenones to Benzoxazoles by a One-Pot Sustainable Synthesis was written by Rancan, Elia;Arico, Fabio;Quartarone, Giuseppe;Ronchin, Lucio;Vavasori, Andrea. And the article was included in Catalysis Letters in 2015.Product Details of 5676-58-4 This article mentions the following:

A series of 2-methyl-benzoxazoles e. g., I, have been synthesized starting from 2-hydroxy-acetophenones via a one-pot three steps reaction. Hydroxylamonium salt has been used as amidation agent. The reaction occurs with different anions, but the best results is achieved with hydroxylamonium hydrchloride. Despite the number of consecutive stages, the reaction is highly selective. Mild reaction conditions and various solvents can be used, but trifluoroacetic acid is the preferred. Almost, complete recovery of the trifluoroacetic acid can be achieved by vacuum distillation The role of trifluoroacetic acid, as well as, of the hydroxylamonium salt suggests a cooperative effect leading to high selective formation of 2-methyl-benzoxazoles. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Product Details of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Product Details of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of Benzazoles through Electrochemical Oxidative Cyclization Reactions was written by An, Qi;He, Chaoyin;Fan, Xiaodong;Hou, Chuanfu;Zhao, Jian;Liu, Yue;Liu, Hao;Ma, Junjie;Sun, Zhizhong;Chu, Wenyi. And the article was included in ChemElectroChem in 2020.Synthetic Route of C13H8BrNO This article mentions the following:

An effective method for the synthesis of benzazoles through the electrochem. oxidative cyclization of o-aminophenol/o-aminothiophenol/o-phenylenediamine and aldehydes was developed. A series of benzazoles were efficiently synthesized by using this method in good yields. Furthermore, this method was applied to the synthesis of the drug thiabendazole in a gram-scale reaction, which proved the practicality of the method. This approach avoids using catalysts and oxidants and has the advantages of wide substrate range, mild reaction conditions and good tolerance of functional groups. Finally, the possible reaction mechanism was proposed and supported by cyclic voltammetry (CV) and control experiments In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Synthetic Route of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Synthetic Route of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Iodine Promoted One-Pot Synthesis of 2-Aryl Benzoxazoles from Amidoximes via Oxidative Cyclization and Ring Contraction was written by Zhang, Yong;Ji, Min. And the article was included in European Journal of Organic Chemistry in 2019.Recommanded Product: 99586-31-9 This article mentions the following:

A mol. I₂-promoted one-pot synthesis of 2-aryl benzoxazoles was developed by using amidoximes rather than the limited 2-aminophenols or 2-haloamides as substrates. The amidoxime substrates provided unique and efficient strategies for converting readily available aniline and benzaldehyde precursors into valuable chems. This transformation proceeded smoothly under transition-metal-free conditions through a sequential oxidative cyclization and ring contraction and provided a potential route for introducing certain groups at any site of the scaffold. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Efficient and divergent synthesis of benzoxazoles and 1,2-benzisoxazoles from o-hydroxyaryl ketoximes was written by Li, Zhenhua;Jin, Guoqiang;Qin, Jingjing;Tan, Zhiyong;He, Jiayu. And the article was included in Heterocycles in 2020.Recommanded Product: 5676-58-4 This article mentions the following:

A bis(trichloromethyl) carbonate (BTC) / triphenylphosphine oxide (TPPO) system promoting tunable cyclization of a variety of o-hydroxyaryl ketoximes to benzoxazoles and benzisoxazoles was developed. The synthetic switch was enabled by base-free or the use of Et₃N. Under base-free conditions, o-hydroxyaryl ketoximes were treated with BTC/TPPO giving corresponding 2-substituted benzoxazoles via cascaded Beckmann rearrangement and intramol. oxa-cyclization. Analogously, the 3-substituted benzisoxazoles were obtained via intramol. nucleophilic substitution reactions in the presence of Et₃N. This process features mild reaction conditions, high chemoselectivity and good functional groups tolerance. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem