Month: January 2023

Modified palladium-catalyzed regioselective ortho-arylation of sp² C-H bond substrates with a low catalyst loading was written by Yang, Fan;Wu, Yangjie;Li, Yanan;Wang, Biao;Zhang, Junli. And the article was included in Tetrahedron in 2009.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A novel and generally applicable system for ortho-arylation of a broad range of sp² C-H bond substrates such as arylated benzoxazoles, acylated anilines, and pyridines has been developed. The arylation was performed in trifluoroacetic acid (TFA) under air by using PdCl₂ as the catalyst with a low catalyst loading of 1 mol %. And it was found for the first time that the addition of weak base K₃PO₄ to the acidic solvent could remarkably enhance the reaction rate. The arylated products were isolated in moderate to good yields with high regioselectivity for the substrates containing a meta-substituent. This arylation is tolerant with various functional groups such as CH₃, CH₃O, CH₃CO, Br, and Cl. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

In-vitro anti-cancer assay and apoptotic cell pathway of newly synthesized benzoxazole-N-heterocyclic hybrids as potent tyrosine kinase inhibitors was written by Desai, Sulaksha;Desai, Vidya;Shingade, Sunil. And the article was included in Bioorganic Chemistry in 2020.Name: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A series of benzoxazole-N-heterocyclic hybrids I [R¹ = H, Br; Ar = 4-BrC₆H₄, 4-O₂NC₆H₄, quinoxalin-2-yl, etc.] was synthesized by a one-pot strategy. The mol. docking studies showed that compounds I to be inhibitors of tyrosine kinase enzyme which triggered growth of cancer cells. The cytotoxicity study of compounds I [R¹ = H, Ar = quinoxalin-2-yl, 2-chloro-3-quinolyl; R¹ = Br, Ar = 4-BrC₆H₄, 4-O₂NC₆H₄, quinoxalin-2-yl, 2-chloro-3-quinolyl] showed better potency against breast cancer cell lines MCF-7 and MDA-MB-231 in contrast to oral and lung cancer cell lines KB and A549. The tyrosine kinase activity was measured using universal tyrosine kinase assay kit using horseradish peroxide (HRP)-conjugated anti-phosphotyrosine kinase solution as a substrate. The compound I [R¹ = Br, Ar = quinoxalin-2-yl] exhibited maximum inhibition in activity of enzyme tyrosine kinase with IC₅₀ value 0.10 ± 0.16μM, than other compounds I which were studied and thus proved to be inhibitors of enzyme tyrosine kinase. The selective index of compounds I [R¹ = H, Ar = quinoxalin-2-yl, 2-chloro-3-quinolyl; R¹ = Br, Ar = 4-BrC₆H₄, 4-O₂NC₆H₄, quinoxalin-2-yl, 2-chloro-3-quinolyl] indicated non-toxic behavior, i.e. good anti-cancer activity. Further, fluorescence microscopic study helped to characterize the mode of cell death, which was found to be late apoptosis as indicated by orange fluorescence. The SAR anal. was also carried out. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Name: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A cationic iridium-catalyzed C(sp³)-H silylation of 2-Alkyl-1,3-azoles at the α-position in the 2-alkyl group leading to 2-(1-Silylalkyl)-1,3-azoles was written by Hirano, Masaya;Fukumoto, Yoshiya;Matsubara, Nao;Chatani, Naoto. And the article was included in Chemistry Letters in 2018.Safety of 2,5-Dimethylbenzoxazole This article mentions the following:

The regioselective silylation of the α-C(sp³)-H bond in the 2-alkyl group in 2-alkyl-1,3-azole derivatives with hydrosilanes, catalyzed by the combination of (POCOP^tBu)IrHCl and NaBAr^F₄, leading to the production of 2-(1-silylalkyl)-1,3-azoles is described. The presence of 3,5-dimethylpyridine is required for the reaction to proceed. Although the reaction takes place both in the presence and absence of a hydrogen acceptor, the addition of an acceptor gave better results, in terms of the efficiency of the reaction. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Safety of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Safety of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Multicatalytic Beckmann rearrangement of 2-hydroxylarylketone oxime: Switchable synthesis of benzo[d]oxazoles and N-(2-hydroxylaryl)amides was written by Li, Zhen;Fang, Chengtao;Zheng, Yannan;Qiu, Guanyinsheng;Li, Xiaofang;Zhou, Hongwei. And the article was included in Tetrahedron Letters in 2018.Application of 5676-58-4 This article mentions the following:

A switchable synthesis route was developed for benzo[d]oxazole derivatives and (2-hydroxylaryl)benzamide from 2-hydroxylbenzeneketoxime using organomols. (BOP-Cl, and CNC) and Lewis acid cocatalyzed Beckmann rearrangement (BR) reaction. Further, this reaction was switched using different organocatalysts. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Application of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Absorption and fluorescence characteristics of some 2-alkyl- and 2-arylbenzoxazoles in different solvents and at various acid concentrations was written by Dey, Joy Krishna;Dogra, Sneh K.. And the article was included in Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical in 1990.Recommanded Product: 2,5-Dimethylbenzoxazole This article mentions the following:

Absorption and fluorescence spectral characteristics of some 2-alkyl- and 2-arylbenzoxazoles have been studied in different solvents and at various acid concentrations Dual fluorescence observed in the monocations of 2-alkylbenzoxazoles is due to π^* → π and charge transfer (CT) transitions, indicating the near degeneracy of excited single states. 2-Arylbenzoxazoles and the corresponding monocations exhibit only a single fluorescence band due to π^* → π transition. PK_a values for the monocation-neutral equilibrium in both S₀ and S₁ states of the mols. have been determined PPP method for all the mols. and CNDO/S method for 2-methyl-, and 2-phenylbenzoxazoles have been employed to calculate transition energies, transition polarization and charge densities at different atoms in the S₀ and S₁ states to substantiate exptl. data and, hence, to verify the applicability of the methods for heterocycles containing two hetero atoms. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Recommanded Product: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A comparative study of symmetrical and unsymmetrical trimethine cyanine dyes bearing benzoxazolyl and benzothiazolyl groups was written by Shi, Quan-Quan;Sun, Ru;Ge, Jian-Feng;Xu, Qing-Feng;Li, Na-Jun;Lu, Jian-Mei. And the article was included in Dyes and Pigments in 2012.Recommanded Product: 2,5-Dimethylbenzoxazole This article mentions the following:

Six sym. and unsym. trimethine cyanine dyes bearing benzothiazolyl and benzoxazolyl groups were synthesized. Their linear optical properties were studied. The variation of hetero atoms play an important role in the spectral properties of the dyes. Sequential replacement of the oxygen atom by the sulfur atom resulted in a change in shade from yellow to purple. In order to understand the relation between the mol. structures and the spectral properties of these dyes, theor. calculations were made using the Gaussian program. Key parameters related to absorption and emission spectra were reported and discussed. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles was written by Saha, Prasenjit;Ramana, Tamminana;Purkait, Nibadita;Ali, Ashif Md;Paul, Rajesh;Punniyamurthy, Tharmalingam. And the article was included in Journal of Organic Chemistry in 2009.COA of Formula: C13H8BrNO This article mentions the following:

The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramol. cyclization of o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. E.g., cyclization of o-bromoaryl amidine I gave 95% benzimidazoles II. The procedure is exptl. simple, general, efficient, and free from addition of external chelating ligands. It is a heterogeneous process and the copper(II) oxide nanoparticles can be recovered and recycled without loss of activity. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9COA of Formula: C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.COA of Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Silica-sulfuric acid catalyzed microwave-assisted synthesis of substituted benzoxazoles and their antimicrobial activity was written by Anand, M.;Ranjitha, A.;Himaja, M.. And the article was included in International Research Journal of Pharmacy in 2011.COA of Formula: C9H9NO This article mentions the following:

Benzoxazole derivatives were designed for a study of their biol. activity, the synthesis of the target compounds was achieved by a microwave-mediated method using sulfated silica (solid acid) as catalyst and ortho esters and 2-aminophenol derivatives as starting materials and the products thus obtained were confirmed by ¹H-NMR and MS. The title compounds were screened against Staphylococcus aureus, Escherichia coli, Candida albicans and Candida glabrata (yeast) and it was discovered that these compounds displayed antimicrobial activity in comparison with Trimethoprim and Miconazole. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Application of nano SnO₂ as a green and recyclable catalyst for the synthesis of 2-aryl or alkylbenzoxazole derivatives under ambient temperature was written by Vahdat, Seyed Mohammad;Raz, Shima Ghafouri;Baghery, Saeed. And the article was included in Journal of Chemical Sciences (Bangalore, India) in 2014.Synthetic Route of C9H9NO This article mentions the following:

Application of nano-SnO₂ as an efficient and environmentally benign catalyst was explored for the synthesis of 2-arylbenzoxalzole derivatives I [R = Ph, 2-HOC₆H₄, 2-MeOC₆H₄, 2-furyl, 3-Cl, 2-thienyl, etc., R¹ = H, Me, Cl, NO₂] or 2-alkylbenzoxazole derivatives I [R = H, Me, Et, R¹ = H, Me, Cl] via condensation reaction of 2-aminophenols with aryl aldehydes or orthoesters, resp. The SnO₂ nanocatalyst is reusable, cheap and eco-friendly. This catalyst offers several advantages including mild reaction conditions, high yield of products, lower catalyst loading and shorter reaction times with simple exptl. and isolation procedures. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Synthetic Route of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Synthetic Route of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Expeditious and efficient synthesis of benzoxazoles, benzothiazoles, benzimidazoles catalyzed by Ga(OTf)₃ under solvent-free conditions was written by Liu, Juyan;Liu, Qian;Xu, Wei;Wang, Weilu. And the article was included in Chinese Journal of Chemistry in 2011.Application In Synthesis of 2,5-Dimethylbenzoxazole This article mentions the following:

A new and efficient method for the synthesis of benzoxazoles, benzothiazoles, benzimidazoles by cyclocondensation of o-substituted aminoaroms. with ortho esters in the presence of catalytic amounts of Ga(OTf)₃ under solvent-free conditions is presented. The remarkable features of this new protocol are high conversion, very short reaction times, cleaner reaction profiles under solvent-free conditions, straightforward procedure, and use of a relatively non-toxic catalyst. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application In Synthesis of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Application In Synthesis of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem