Month: January 2023

Biochemical and Structural Evaluation of Highly Selective 2-Arylbenzoxazole-Based Transthyretin Amyloidogenesis Inhibitors was written by Johnson, Steven M.;Connelly, Stephen;Wilson, Ian A.;Kelly, Jeffery W.. And the article was included in Journal of Medicinal Chemistry in 2008.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

To develop potent transthyretin (TTR) amyloidogenesis inhibitors that also display high binding selectivity in blood, it proves useful to systematically optimize each of the three substructural elements that comprise a typical inhibitor: the two aryl rings and the linker joining them. In the first study, described herein, structural modifications to one aryl ring were evaluated by screening a library of 2-arylbenzoxazoles bearing thyroid hormone-like aryl substituents on the 2-aryl ring. Several potent and highly selective amyloidogenesis inhibitors were identified that exhibit minimal thyroid hormone nuclear receptor and COX-1 binding. High resolution crystal structures (1.3-1.5 A) of three inhibitors (I, II, and III) in complex with TTR were obtained to characterize their binding orientation. Collectively, the results demonstrate that thyroid hormone-like substitution patterns on one aryl ring lead to potent and highly selective TTR amyloidogenesis inhibitors that lack undesirable thyroid hormone receptor or COX-1 binding. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Studies on the synthesis and photochemical properties of chain linked bisheteroarylethenes was written by Zhang, Wen-Qin;Wang, Shu-Li;Zhao, Hai-Tao;Zhuang, Jun-Peng;Sun, Hao;Zhao, Shu-Na;Zheng, Yan;Li, Chun-Bao. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2000.Quality Control of 2,5-Dimethylbenzoxazole This article mentions the following:

1,3-Bis[trans-4-[2-[2-(5-methylbenzoxazolyl)]ethenyl]phenoxy]propane, 1,4-Bis[trans-4-[2-[2-(5-methylbenzoxazolyl)]ethenyl]phenoxy]butane, 1,6-Bis[trans-4-[2-[2-(5-methylbenzoxazolyl)]ethenyl]phenoxy]hexane, and 2,2′-bis[trans-4-[2-[2-(5-methylbenzoxazolyl)]ethenyl]phenoxy]ethyl ether were synthesized. Their structures were identified by elemental anal., IR, UV, ¹H NMR, ¹³C NMR and MS. The UV spectra were used to illustrate the change of title compounds under the irradiation of high-pressure-mercury-lamp. It was found that these compounds undergo two kinds of reactions, the trans-cis isomerization and intramol. photodimerization. The former is fast and reversible, and the latter is slow and irreversible. The speed of intramol. photodimerization will increase with increasing the length of the carbon chain between the two 2-[[2-(5-methylbenzoxazolyl)]ethenyl]phenyl group. The fact that the photodimerization is not affected by oxygen shows that the reaction proceeds through an excited singlet state. It is also revealed that title compounds undergo [2+2] photolysis easily when irradiated under short UV light. That the intramol. photodimerization and photolysis of these compounds can repeat many times indicate that these compounds have a high photostability. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Quality Control of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Quality Control of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Tungstate sulfuric acid as an efficient catalyst for the synthesis of benzoxazoles and benzothiazoles under solvent-free conditions was written by Farahi, Mahnaz;Karami, Bahador;Azari, Masume. And the article was included in Comptes Rendus Chimie in 2013.Formula: C9H9NO This article mentions the following:

Tungstate sulfuric acid (TSA) was found to be an efficient and reusable catalyst for the synthesis of benzoxazole and benzothiazole derivatives via reactions of ortho esters with o-aminophenols or o-aminothiophenols in high yields. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Palladium (II) Complex Supported on Magnetic Nanoparticles Modified with Phenanthroline: A Highly Active Reusable Nanocatalyst for the Synthesis of Benzoxazoles, Benzothiazoles and Cyanation of Aryl Halides was written by Cai, Yuan;Yuan, Hailong;Gao, Qiang;Wu, Lili;Xue, Lijun;Feng, Nengjie;Sun, Yuan. And the article was included in Catalysis Letters.Application of 99586-31-9 This article mentions the following:

A well dispersed magnetically separable palladium complex (MNPs-phenanthroline-Pd) has been synthesized via the immobilization of palladium (II) complex on the surface of silica-coated magnetic nanoparticles modified with phenanthroline ligand. The SEM and TEM images of MNPs-phenanthroline-Pd at different magnification show that the catalyst is formed of nanometer-sized particles. The MNPs-phenanthroline-Pd nanocomposite was found to be an efficient catalyst for the synthesis of benzoxazoles, benzothiazoles and cyanation of aryl halides. The high efficiency and the ability to be recovered and reused for at least up to seven consecutive runs are some superior properties of the catalyst. SEM images of reused catalyst confirmed that there was no significant change in the morphol. and dispersion of the particles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Application of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of diheteroarylacetylenes containing benzoxazole and pyridine groups was written by Liu, Jie;Zhuang, Jun-peng;Hao, Hai-jun;Zhang, Shu-guang;Niu, Jun-yu. And the article was included in Huaxue Shiji in 2015.Product Details of 5676-58-4 This article mentions the following:

Diheteroarylacetylenes containing benzoxazole and pryidine groups were synthesized from diheteroarylethenes in moderate yields by bromination with Br₂ in refluxing dichloromethane and then debromination with KOH-tBu in THF at room temperature Compared with the transition-metal-catalyzed methods, this procedure provided a metal-free, efficient and economical method with easily accessible starting materials form the synthesis of diheteroarylacetylenes. The UV and FL spectra were determined The photochem. determination showed that these diheteroarylethenes were photoinert to UV irradiation in organic solvent or in acidic aqueous solution In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Product Details of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Product Details of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Palladium catalyzed C_sp²-H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals was written by Seth, Kapileswar;Nautiyal, Manesh;Purohit, Priyank;Parikh, Naisargee;Chakraborti, Asit K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Name: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A novel strategy for direct aryl hydroxylation via Pd-catalyzed C_sp²-H activation through an unprecedented hydroxyl radical transfer from 1,4-dioxane, used as a solvent, is reported with bio relevant and sterically hindered heterocycles and various acyclic functionalities as versatile directing groups. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Name: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of triphenylamines via ligand-free selective ring-opening of benzoxazoles or benzothiazoles under superparamagnetic nanoparticle catalysis was written by Nguyen, Oanh T. K.;Nguyen, Long T.;Truong, Nhu K.;Nguyen, Viet D.;Nguyen, Anh T.;Le, Nhan T. H.;Le, Dung T.;Phan, Nam T. S.. And the article was included in RSC Advances in 2017.COA of Formula: C9H9NO This article mentions the following:

CuFe₂O₄ superparamagnetic nanoparticles were utilized as an effective recyclable heterogeneous catalyst for the synthesis of triphenylamines 2-HY-R-C₆H₃N(C₆H₄R¹)₂ (R = H, 5-Me; R¹ = H, 2-Me, 3-MeO, etc.; Y = S, O) via the ligand-free selective ring-opening reaction of benzoxazole, 2,5-dimethylbenzoxazole or benzothiazole with iodoarenes R¹C₆H₄X (X = I, Br, Cl). The nano CuFe₂O₄ demonstrated noticeably higher catalytic efficiency than a series of homogeneous catalysts and heterogeneous catalysts. It was possible to sep. the nano CuFe₂O₄ by using a magnet, and the recovered catalyst was reused many times while its activity could be maintained. This is the first example of heterogeneous catalysis for the transformation of benzoxazoles, and the transformation of benzothiazoles to triphenylamines has been reported. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Isolation and identification of new components in the ether-soluble portion of cigarette smoke condensate was written by Newell, Marjorie P.;Heckman, Robert A.;Moates, Robert F.;Green, Charles R.;Best, Freddie W.;Schumacher, J. N.. And the article was included in Tobacco Science in 1978.Synthetic Route of C9H9NO This article mentions the following:

Smoke condensates from 4 different 85-mm nonfiltered, uncased cigarettes smoked under standard conditions were partitioned between ether and water. The ether-soluble material, ∼60% of the total, was chromatographed on silicic acid with increasingly polar solvents to give 7 fractions. Further separation of the fractions by liquid-liquid partitions, column chromatog., and semi-preparative gas-liquid chromatog. led to the isolation and identification of 643 compounds, of which 173 were not previously reported as smoke components. Identification of individual isolates was accomplished by comparison of their IR, NMR, MS, and gas-liquid chromatog. retention times with those of authentic samples. The new isolates include 13 acids, 13 lactones, 2 aldehydes, 56 ketones, 4 alcs., 15 phenols, 19 N heterocyclics, 15 aliphatic hydrocarbons, 33 cyclic hydrocarbons, and 3 miscellaneous compounds A number of these new compounds are known to be in tobacco leaf. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Synthetic Route of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Synthetic Route of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Silica sulfuric acid catalyzed synthesis of benzoxazoles, benzimidazoles and oxazolo[4,5-b]pyridines under heterogeneous and solvent-free conditions was written by Mohammadpoor-Baltork, I.;Moghadam, M.;Tangestaninejad, S.;Mirkhani, V.;Zolfigol, M. A.;Hojati, S. F.. And the article was included in Journal of the Iranian Chemical Society in 2008.Reference of 5676-58-4 This article mentions the following:

A simple, rapid and efficient method for the preparation of benzoxazoles, benzimidazoles and oxazolo[4,5-b]pyridines from the reaction of orthoesters with o-aminophenols, o-phenylenediamine and 2-amino-3-hydroxypyridine in the presence of silica sulfuric acid under heterogeneous and solvent-free conditions is reported. The significant features of this method are short reaction times, high yields of the products, mild reaction conditions, solvent free reaction, cheapness, non-toxicity and reusability of the catalyst. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Reference of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Reference of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis and polymorphism of 2-(4′-nitrostyryl)benzoxazole and its derivatives was written by Shen, Yongjia;Han, Pingyang;Ren, Shengwu. And the article was included in Huadong Huagong Xueyuan Xuebao in 1990.Product Details of 5676-58-4 This article mentions the following:

2-(4′-Nitrostyryl)-benzoxazole and its 5-Me, nitro, acetamino, and Ph derivatives were synthesized. Their thermal behaviors and polymorphism were determined by DSC and x-ray diffraction. They have α, β modifications; the α-modification is thermo-unstable and can transform into the β-modification on heating. The ΔH_m, ΔS_m, and m.p. of the α-modification are lower than those of the β-modification. The melt of the α-modification is a supercooled liquid in contrast to the β-modification. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Product Details of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Product Details of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem