Day: February 9, 2023

Microwave irradiation promoted synthesis of 2-substituted benzoxazole compound was written by Guo, Qiang;Yang, Yafen;Cheng, Biao;Zhang, Fengtao;Fan, Xuesen. And the article was included in Henan Shifan Daxue Xuebao, Ziran Kexueban in 2013.Reference of 99586-31-9 This article mentions the following:

A clean and efficient synthesis of 2-substituted benzoxazole compound through tandem reactions of 2-aminophenol and aldehydes mediated with [bmim][BF₄] under MWI has been developed. Compared with literature methods toward 2-substituted benzoxazole compound, the synthetic strategy presented in the paper has such advantages as enhanced reaction rate, high yield and environmental protection. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Reference of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Reference of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors was written by Connelly, Stephen;Mortenson, David E.;Choi, Sungwook;Wilson, Ian A.;Powers, Evan T.;Kelly, Jeffery W.;Johnson, Steven M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

Rate-limiting dissociation of the tetrameric protein transthyretin (TTR), followed by monomer misfolding and misassembly, appears to cause degenerative diseases in humans known as the transthyretin amyloidoses, based on human genetic, biochem. and pharmacol. evidence. Small mols. that bind to the generally unoccupied thyroxine binding pockets in the native TTR tetramer kinetically stabilize the tetramer, slowing subunit dissociation proportional to the extent that the mols. stabilize the native state over the dissociative transition state-thereby inhibiting amyloidogenesis. Herein, the authors use previously reported structure-activity relationship data to develop two semi-quant. algorithms for identifying the structures of potent and selective transthyretin kinetic stabilizers/amyloidogenesis inhibitors. The viability of these prediction algorithms, in particular the more robust in silico docking model, is perhaps best validated by the clin. success of tafamidis, the first-in-class drug approved in Europe, Japan, South America, and elsewhere for treating transthyretin aggregation-associated familial amyloid polyneuropathy. Tafamidis is also being evaluated in a fully-enrolled placebo-controlled clin. trial for its efficacy against TTR cardiomyopathy. These prediction algorithms will be useful for identifying second generation TTR kinetic stabilizers, should these be needed to ameliorate the central nervous system or ophthalmol. pathol. caused by TTR aggregation in organs not accessed by oral tafamidis administration. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Sodium dichloroiodate promoted C-C bond cleavage: An efficient synthesis of 1,3-benzazoles via condensation of o-amino/mercapto/hydroxyanilines with β-diketones was written by Bhagat, Saket B.;Ghodse, Shrikant M.;Telvekar, Vikas N.. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2018.Electric Literature of C9H9NO This article mentions the following:

An efficient aqueous sodium dichloroiodate (NaICl₂) mediated protocol is developed for the synthesis of benzo-fused azoles I (R¹ = H, Me, Cl; R² = Me, Et, i-Pr, Ph; X = NH, O, S) by the cyclization of 2-amino-substituted anilines, thiophenols or phenols 2-HX-5-R¹C₆H₃NH₂ with β-diketone compounds R²C(O)CH₂C(O)R³ (R³ = Me, Et, i-Pr, Ph). The reactions gave moderate to good yield of the corresponding 2-substituted benzimidazoles, benzothiazoles or benzoxazoles, resp., under mild conditions. This tandem process involved a C-C bond cleavage and C-N bond formation. The reaction provides a rapid access to 1,3-benzazoles I in good yields, thus speeding up the drug discovery process. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Electric Literature of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A novel strategy for the construction of substituted benzoxazoles via a tandem oxidative process was written by Gu, Lijun;Jin, Cheng;Guo, Junming;Zhang, Lizhu;Wang, Wei. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2013.Name: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A practical and simple synthesis of benzoxazoles from easily available substrates was developed. The protocol is triggered by an iron-catalyzed tandem oxidative process from simple toluene derivatives and 2-aminophenols. This method represents a straightforward approach to access substituted benzoxazoles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Name: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Heterogeneous palladium (II)-complexed dendronized polymer: A rare palladium catalyst for the one-pot synthesis of 2-arylbenzoxazoles was written by George, Smitha;Sreekumar, Krishnapillai. And the article was included in Applied Organometallic Chemistry in 2021.Name: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

The palladium complex of dendronized amine polymer (EG-Gn-Pd, n = 0, 1 and 2) having ethylene glycol-initiated polyepichlorohydrin as core was synthesized on a Merrifield resin support and was well characterized. Generally, palladium catalysts are known for carbon-carbon coupling reactions. Here, a developed catalyst was found to be good for benzoxazole synthesis. Higher generation dendronized polymer (EG-G2-Pd) was found to be better catalyst over lower generation dendronized polymers. Moreover, dendronized polymers were found to be a better catalyst over dendrigraft polymers. The catalyst reusability was checked and good yield was obtained for five cycles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Name: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Research on benzoxazole compounds. I. Synthesis and photophysical properties was written by Shen, Yongjia;Ren, Shengwu;Wang, Bingkui. And the article was included in Huadong Huagong Xueyuan Xuebao in 1990.SDS of cas: 5676-58-4 This article mentions the following:

Benzoxazoles I (R = H, Me, Cl, Ph; Z = CH:CHC₆H₄, CH:CHC₆H₄CH:CH, C₆H₄CH:CHC₆H₄) and II (R¹ = H, Me, Cl) were prepared E.g. condensation of 2-HOC₆H₄NH₂ with 4-(ClCO)C₆H₄CH:CHCOCl gave I (R = H, Z = CH:CHC₆H₄). IR, UV, fluorescence, and laser emission spectra of I–II were reported. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.SDS of cas: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Aggregation of unsymmetrical anionic carbocyanine. I. Preparation and aggregation of sodium salt of 1′-ethyl-3,3′-bis-(3-sulfopropyl)-5-methoxy-5′,6′-dichlorobenzimidazolooxacarbocyanine was written by Huang, Guangtuan;Lu, Minghu;Huang, Deyin. And the article was included in Huadong Ligong Daxue Xuebao in 1998.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

The anionic carbocyanine dye, sodium salt of 1′-ethyl-3, 3′-bis-(3-sulfopropyl)-5-methoxy-5′,6′-dichloro-benzimidazolo-oxa-carbocyanine and its intermediates were synthesized. Its structure has been characterized by IR, ¹H-NMR and MS. UV-Vis spectra of this dye in Me alc., water, 1,2-dichloroethane, chlorobenzene and bromobenzene have been determined This dye could not form J-aggregate when its concentration was 1 x 10^-5 mol/L in Me alc. and water. When it was dissolved in 1,2-dichloroethane, chlorobenzene and bromobenzene, it tended to form J-aggregate. The process of aggregation has also been studied for the solution of this dye dissolved in chloroform. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Name: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Regioselective Syntheses of 2- and 4-Formylpyrido[2,1-b]benzoxazoles was written by Li, Ke-Lai;Du, Zong-Bo;Guo, Can-Cheng;Chen, Qing-Yun. And the article was included in Journal of Organic Chemistry in 2009.Electric Literature of C9H9NO This article mentions the following:

O-Acetaminophenols I (R = H, Cl, Me, t-Bu, NO₂, OMe, Ph) reacted with Vilsmeier reagent under Meth-Cohn conditions to yield 2-formylpyrido[2,1-b]benzoxazoles II unexpectedly besides the known compounds III. Refluxing III in acetic anhydride gave 4-formylpyrido[2,1-b]benzoxazoles IV, the regioisomers of II. II (R = H) and IV (R = H) were structurally characterized by X-ray crystallog. A mechanism for the formation of II involving sequential chlorination, dimerization, intramol. elimination of HCl to form the oxazole ring, formylation twice, and regioselective intramol. nucleophilic cyclization to construct the pyridone ring is proposed. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Electric Literature of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Reaction of oximes of 2-hydroxyacetophenone, chalcone, flavanone, and flavone was written by Bagade, M. B.;Ghiya, B. J.. And the article was included in Asian Journal of Chemistry in 1991.SDS of cas: 5676-58-4 This article mentions the following:

Oximes of 2-hydroxyacetophenone, chalcone, flavanone, and flavone were prepared by the action of hydroxylamine hydrochloride on the resp. compounds The oximes gave back the starting material by the action of HCl, nitrous acid or CrO₃ in AcOH. 2-Hydroxy-5-methylacetophenone oxime (I), with POCl₃, cyclized to give benzoxazole II. I also condensed with RCHO (R = Ph, 4-MeOC₆H₄) to give chalcone oxime III. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.SDS of cas: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

One-pot synthesis of benzoxazoles via the metal-free ortho-C-H functionalization of phenols with nitroalkanes was written by Aksenov, Nicolai A.;Aksenov, Alexander V.;Nadein, Oleg N.;Aksenov, Dmitrii A.;Smirnov, Alexander N.;Rubin, Michael. And the article was included in RSC Advances in 2015.Recommanded Product: 2,5-Dimethylbenzoxazole This article mentions the following:

A one-pot cascade transformation involving metal-free and oxidant-free direct ortho-C-H functionalization, followed by Beckman rearrangement and intramol. cyclocondensation to produce benzoxazoles I [R¹ = H, Me, Et, i-Pr, OH; R² = H, Me, OH, F; R³ = H, Me; R⁴ = CH₃, CH₂CH₃, (CH₂)₄CH₃, C₆H₅, C₆H₅CH₂] and benzobisoxazoles II (R⁵ = CH₃, C₆H₅CH₂; R⁶ = H, Me) directly from easily available phenols and PPA-activated nitroalkanes. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Recommanded Product: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem