Day: February 9, 2023

Palladium-catalyzed ortho-nitration of 2-arylbenzoxazoles was written by Qiao, Hui-Jie;Yang, Fan;Wang, Shi-Wei;Leng, Yu-Ting;Wu, Yang-Jie. And the article was included in Tetrahedron in 2015.Computed Properties of C13H8BrNO This article mentions the following:

An efficient and general protocol for palladium-catalyzed chelation-assisted ortho-nitration of 2-arylbenzoxazoles has been developed. This nitration exhibits high regioselectivity for the substrates, and the reaction could tolerate many functional groups such as F, Cl, Br, CH₃, CH₃O, affording ortho-nitration products in moderate to good yields. Moreover, some 2-arylbenzoxazole heterocyclic analogs proceed well under this catalytic system. Further studies have been performed to obtain insight into the mechanism. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Computed Properties of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Computed Properties of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Phosphonium acidic ionic liquid: an efficient and recyclable homogeneous catalyst for the synthesis of 2-arylbenzoxazoles, 2-arylbenzimidazoles and 2-arylbenzothiazoles was written by Nguyen, Quang The;Hang, Anh-Hung Thi;Nguyen, Thuy-Linh Ho;Chau, Duy-Khiem Nguyen;Tran, Phuong Hoang. And the article was included in RSC Advances in 2018.SDS of cas: 99586-31-9 This article mentions the following:

A highly efficient and green strategy was developed for the synthesis of 2-arylbenzoxazoles, 2-arylbenzimidazoles and 2-arylbenzothiazoles I [R = H, Me, Cl, NO₂; Ar = Ph, 4-FC₆H₄, 4-pyridyl, etc.; X = NH, O, S] via phosphonium acidic ionic liquid catalyzed condensation of o-aminophenols, o-phenylenediamine and o-aminothiophenol, resp. with aryl aldehydes. Triphenyl(butyl-3-sulfonyl)phosphonium toluenesulfonate catalyst was easily obtained from cheap and available starting materials through a one-pot synthesis and its structure was identified by ¹H NMR, ¹³C NMR, ³¹P NMR, and FT-IR techniques. Other properties including thermal stability and acidity were determined by TGA and Hammett acidity function method. The merits of this protocol were good yield, short reaction time, broad substrate scope, mild conditions and recyclability of catalyst. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9SDS of cas: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.SDS of cas: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Correlation of N.M.R. chemical shifts of 2-methyl protons of substituted benzazoles with Hammett’s substituents constants was written by Modica, Gaetano Di;Barni, Ermanno;Gasco, Alberto. And the article was included in Journal of Heterocyclic Chemistry in 1965.Recommanded Product: 2,5-Dimethylbenzoxazole This article mentions the following:

The chem. shifts of 2-methyl protons of twenty-one 5- and 6-substituted benzazoles determined in carbon tetrachloride solution, were plotted against the Hammett substituent constants using σ_m for groups in the 5- position and σ_p for groups in the 6-position, obtaining satisfactory linear correlations. These results are taken to indicate that electronic effects are transmitted to the 2-position predominantly through the N atom and that virtually no transmission occurs through the hetero atom. The deshielding effect of the hetero atom is opposite to the electronegativity and this may be qual. explained in terms of different aromaticity of these heterocycles. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Recommanded Product: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem