Day: February 22, 2023

Copper and cobalt co-catalyzed aerobic oxidative cross-dehydrogenative coupling reaction of (benzo)azoles was written by Li, Yanrong;Qian, Fen;Ge, Xia;Liu, Tao;Jalani, Hitesh B.;Lu, Hongjian;Li, Guigen. And the article was included in Green Chemistry in 2019.Name: 5-Methoxybenzo[d]oxazole This article mentions the following:

The dehydrogenative cross-coupling (CDC) reaction of diversely substituted azoles, e.g., benzoxazole synergistically catalyzed by copper and cobalt, is reported. This protocol represents the first example of the use of air as an oxidant to carry out this chem. reaction. The process provides a convenient and economical method for the construction of valuable unsym. bis-heteroaryl compounds, e.g., 2-(benzo[d]thiazol-2-yl)benzo[d]oxazole including bis-benzoazole compounds that are not obtained in previous catalytic CDC reactions. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Name: 5-Methoxybenzo[d]oxazole).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Name: 5-Methoxybenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A new 5-HT₃ receptor ligand. II. Structure-activity analysis of 5-HT₃ receptor agonist action in the gut was written by Yamada, Megumi;Sato, Yasuo;Kobayashi, Kazuko;Konno, Fukio;Soneda, Tomoko;Watanabe, Takashi. And the article was included in Chemical & Pharmaceutical Bulletin in 1998.Category: benzoxazole This article mentions the following:

Several modified 2-piperazinyl benzoxazole derivatives, which exhibit an agonistic effect on gastrointestinal motility, were synthesized and their effects on the contraction of guinea-pig ileum were examined The quaternary piperazinyl benzoxazole structure has a restricted conformation and stereostructure compared to those of the other 5-HT₃ receptor agonists, serotonin and meta-chlorophenylbiguanide. The mutual positions of the aromatic ring, N atom and terminal amine are considered to form the pharmacophore of the 5-HT₃ receptor agonist in the gut. In the serotonin-evoked reflex bradycardia [Bezold-Jarisch (B-J) reflex] inhibition test using rats the B-J reflex-inducing ratio was different for each synthesized compound Probably in these 5-HT₃ receptor agonists, the substituents of the benzoxazole ring influence the B-J reflex-inducing activity in rats. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Category: benzoxazole).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Nickel-catalyzed C-H arylation of benzoxazoles and oxazoles: Benchmarking the influence of electronic, steric and leaving group variations in phenolic electrophiles was written by Steinberg, Deborah F.;Turk, Morgan C.;Kalyani, Dipannita. And the article was included in Tetrahedron in 2017.Application of 132227-03-3 This article mentions the following:

Electronic, steric and leaving group effects for Ni-catalyzed direct arylations using C-O electrophiles were benchmarked. The scope of arylations with pivalates was general with respect to both the electronics on the electrophile and the azoles. Furthermore, the arylation of azoles with tosylates, mesylates and carbamates with varying electronics was explored, and showed electronic trends similar to those of the pivalate reactions. Finally, the relative rate of arylation of 5-Me benzoxazole with two electronically-similar electrophiles bearing different leaving groups was established. The results from these studies implicate the following order of relative reactivity: mesylates>pivalates>carbamates. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Application of 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Application of 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Palladium-Catalyzed Direct Cyclopropylation of Heterocycles was written by Wu, Xiaojin;Lei, Chuanhu;Yue, Guizhou;Zhou, Jianrong. And the article was included in Angewandte Chemie, International Edition in 2015.Application of 132227-03-3 This article mentions the following:

Variously substituted 1,3-azoles (oxazole, benzoxazole, 4-methylthiazole, caffeine, etc.) and 2- and 3-cyanothiophenes were directly cyclopropylated with cyclopropyl iodides in the presence of a simple palladium catalyst. The relative configuration on the three-membered rings was retained in the products. In this process, the cyclopropyl-halide bond underwent concerted oxidative addition to palladium(0), and cyclopropyl radicals were not involved in the productive pathway. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Application of 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Application of 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy was written by Siebenbuerger, Lorenz;Hernandez-Olmos, Victor;Abdelsamie, Ahmed S.;Frotscher, Martin;van Koppen, Chris J.;Marchais-Oberwinkler, Sandrine;Scheuer, Claudia;Laschke, Matthias W.;Menger, Michael D.;Boerger, Carsten;Hartmann, Rolf W.. And the article was included in Journal of Medicinal Chemistry in 2018.Recommanded Product: 936902-12-4 This article mentions the following:

Intracellular elevation of E2 levels in bone by inhibition of 17β hydroxysteroid dehydrogenase type 2 (17β-HSD2) without affecting systemic E2 levels is an attractive approach for a targeted therapy against osteoporosis, a disease which is characterized by loss of bone mineral d. Previously identified inhibitor A shows high potency on human and mouse 17β-HSD2, but poor pharmacokinetic properties when applied perorally in mice. A combinatorial chem. approach was utilized to synthesize truncated derivatives of A, leading to highly potent compounds with activities in the low nanomolar to picomolar range. Compound 33, comparable to A in terms of inhibitor potency against both human and mouse enzymes, displays high in vitro metabolic stability in human and mouse liver S9 fraction as well as low toxicity and moderate hepatic CYP inhibition. Thus, compound 33 showed a highly improved peroral pharmacokinetic profile in comparison to A, making 33 a promising candidate for further development. In the experiment, the researchers used many compounds, for example, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (cas: 936902-12-4Recommanded Product: 936902-12-4).

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (cas: 936902-12-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Recommanded Product: 936902-12-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

An environmentally benign procedure for the synthesis of substituted 2-thiobenzothiazoles, 2-thiobenzoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols was written by Deligeorgiev, Todor G.;Kaloyanova, Stefka S.;Lesev, Nedyalko Y.;Vaquero, Juan J.. And the article was included in Monatshefte fuer Chemie in 2011.Recommanded Product: 6-Methyl-1,3-benzoxazole-2-thiol This article mentions the following:

An improved environmentally benign procedure for the synthesis of substituted 2-thiobenzothiaoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols, e.g., I, by cyclization of 2-aminophenols, 2-aminothiophenols, 1,2-phenylenediamines, or 2-amino-3-hydroxypyridines with potassium O-ethyldithiocarbonate in PEG 400 or glycerol under directed microwave irradiation is described. The method can be applied to the synthesis of a variety of derivatives In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Recommanded Product: 6-Methyl-1,3-benzoxazole-2-thiol).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 6-Methyl-1,3-benzoxazole-2-thiol

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Regioselective Thiolation of Arenes and Heteroarenes: C-H Functionalization Strategy for C-S Bond Formation was written by Varun, Begur Vasanthkumar;Prabhu, Kandikere Ramaiah. And the article was included in Journal of Organic Chemistry in 2014.Formula: C8H7NOS This article mentions the following:

A facile transition-metal-free oxidative cross-dehydrogenative coupling reaction involving selective formation of a C-S bond leading to the synthesis of arylthiobenzoxazoles, heteroarylthiobenzoxazoles, and arylthiobenzothiazoles has been described. This highly regioselective C-H functionalization reaction with electron-rich aromatic systems including heteroaromatics is achieved by reversing the reactivity of sulfur in the presence of a suitable oxidant and strong acid. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Formula: C8H7NOS).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Formula: C8H7NOS

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of 2-(benzylthio)benzimidazole, 2-[(benzimidazol-2-yl)methylthio]benzimidazole and structural analogues against Haemonchus contortus was written by Akpa, Sagne Jacques;Say, Martial Venance;Zoakouma, Roger Simplice Pepin;Fante, Bamba;Sissouma, Drissa;Adjou, Ane. And the article was included in African Journal of Pharmacy and Pharmacology in 2016.Synthetic Route of C8H7NOS This article mentions the following:

The coupling of 2-mercaptobenzimidazoles with (chloromethyl)benzene derivatives gave 2-(benzylthio)benzimidazoles I (R¹ = H, NO₂, C₆H₅CO; R² = H, 4-Cl, 3-NO₂, 2,4-Cl) on one hand, and coupling with the 2-(chloromethyl)benzimidazoles on the other gave 2-[(benzimidazolyl)methylthio]benzimidazoles and analogs II (R⁴ = H, 6-CH₃, 5-NO₂, etc.; R³ = H, NO₂, C₆H₅CO; X = NH, S, O). The evaluation of the anthelmintic activities of these mols. on Haemonchus contortus showed that the introduction of the nitro group (NO₂) in the structure causes a significant increase of the activity. Among the mols. evaluated in vitro for their anti-infectious activity, compounds I (R¹ = H; R² = 3-NO₂) and II (R¹ = 5-NO₂, 5-C₆H₅CO; R² = H, NO₂, C₆H₄CO) revealed an activity which is comparable to that of the reference mols. (ivermectin and fenbendazole). In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Synthetic Route of C8H7NOS).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Synthetic Route of C8H7NOS

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

New flowsheet for the treatment of complex sulfide ores using synthetic collectors was written by Belardi, G.;Alesse, V.;Marabini, A. M.. And the article was included in Minerals & Metallurgical Processing in 1995.COA of Formula: C8H7NOS This article mentions the following:

An alternative flowsheet was designed for the flotation treatment of a complex sulfide ore from the Sotiel Mine in Spain. The ore contains 0.71% Cu, 2.24% Pb and 5.63% Zn. Two specially developed synthetic collectors, methylmercapto-benzoxazole (MMBO) and 6n-propoxy-mercaptobenzo-thiazole (PMBT), were examined MMBO exerts a specific action on copper and zinc minerals after treatment with copper sulfate, and PMBT exerts a specific action on Pb minerals. Flotation operating variables (pH, frother type, frother quantity and feed particle size) were examined by means of rougher flotation tests to determine the optimum conditions for the new collectors. Once the optimum conditions were determined, a series of open flotation circuits were run on feeds of various particle sizes (obtained by different types of grinding). The objective was to obtain high-grade Cu and zn concentrates The results of the open-circuit tests demonstrated that a Cu concentrate grading from 18% to 23% Cu and a Zn concentrate grading from 40% to 48% Zn can be produced. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0COA of Formula: C8H7NOS).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.COA of Formula: C8H7NOS

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

C-H Bond Functionalization of Benzoxazoles with Chromium(0) Fischer Carbene Complexes was written by Hu, Fangdong;Yang, Jinghui;Xia, Ying;Ma, Chen;Xia, Haiping;Zhang, Yan;Wang, Jianbo. And the article was included in Organometallics in 2016.Electric Literature of C8H7NO2 This article mentions the following:

An efficient C-H bond functionalization of benzoxazoles with chromium(0) Fischer carbene complexes under catalyst-free conditions has been developed. A series of benzoxazoles and chromium(0) carbene complexes are compatible with the reaction. This transformation provides an alternative way for C-H bond alkylation of benzoxazoles. In the reaction mechanism the elimination of the Cr(CO)₅ fragment seems more favored than the elimination of an alkoxy group, which is in sharp contrast to the previous reports on the reaction of organolithium reagents with chromium(0) Fischer carbene complexes. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Electric Literature of C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Electric Literature of C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem