Month: February 2023

Facile synthesis of arylboronic esters by palladacycle-catalyzed bromination of 2-arylbenzoxazoles and subsequent borylation of the brominated products was written by Leng, Yuting;Yang, Fan;Zhu, Weiguo;Zou, Dapeng;Wu, Yangjie;Cai, Ranran. And the article was included in Tetrahedron in 2011.SDS of cas: 99586-31-9 This article mentions the following:

An efficient and facile synthesis of arylbenzoxazolyl pinacolboronates has been described using cyclopalladated ferrocenylimines as the catalysts. This reaction includes two steps (bromination of 2-arylbenzoxazoles and borylation of the arylbromobenzoxazoles) in succession. The regioselective bromination of benzoxazoles occurred by electrophilic substitution using NBS as the brominating reagent; the site of bromination was determined by HMBC (¹H-detected heteronuclear multiple bond correlation) spectra of the products. The subsequent borylation could be carried out only after removal of the solvent and addition of a second catalyst to afford the arylboronic esters in moderate to good yields. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9SDS of cas: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.SDS of cas: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis and characterization of amino glucose-functionalized silica-coated NiFe₂O₄ nanoparticles: A heterogeneous, new and magnetically separable catalyst for the solvent-free synthesis of 2,4,5-trisubstituted imidazoles, benzo[d]imidazoles, benzo[d] oxazoles and azo-linked benzo[d]oxazoles was written by Fekri, Leila Zare;Nikpassand, Mohammad;Shariati, Shahab;Aghazadeh, Behnaz;Zarkeshvari, Reza;Norouz pour, Nahid. And the article was included in Journal of Organometallic Chemistry in 2018.Synthetic Route of C13H8BrNO This article mentions the following:

Amino glucose-functionalized silica-coated NiFe₂O₄ nanoparticles (NiFe₂O₄@SiO₂@amino glucose) were chem. synthesized and characterized by transmission electron microscope (TEM), X-ray diffraction (XRD), thermal gravimetric anal. (TGA), energy dispersive X-ray anal. (EDX), vibrating sample magnetometer (VSM), Zetasizer and Fourier transform IR spectroscopy (FT-IR) instruments. NiFe₂O₄@SiO2@amino glucose supply an environmentally friendly procedure for the synthesis of 2,4,5-trisubstituted imidazoles through one-pot multicomponent condensation of benzil or benzoin, ammonium acetate with aryl aldehydes and for the synthesis of benzoxazoles using condensation reaction of 2-aminophenol with aryl aldehydes under solvent free condition. In the other study, this synthesized magnetically reusable catalyst was introduced as a new avenue for the synthesis of benzo[d]imidazoles using the reaction between aryl aldehydes and 1,2-diaminobenzene. These compounds were obtained in high yields and short reaction times. The catalyst could be easily recovered and reused for five cycles with almost consistent activity. Synthesized compounds were characterized by their phys. constant, comparison with authentic samples, FT-IR, ₁H NMR, ₁₃C NMR spectroscopy and elemental anal. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Synthetic Route of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Synthetic Route of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Inhibitors of hepatic mixed function oxidases. V. Inhibition of aminopyrine N-demethylation and enhancement of aniline hydroxylation by benzoxazole derivatives was written by Little, Peter J.;Ryan, Adrian J.. And the article was included in Biochemical Pharmacology in 1982.Recommanded Product: 5676-58-4 This article mentions the following:

All of a series of 12 benzoxazoles tested inhibited aminopyrine N-demethylase (I) activity of rat liver microsomes from phenobarbitone-treated rats, and there was an apparent relation between inhibitory potency and partition coefficient For the 2-alkylbenzoxazole series, inhibitory potency towards I activity increased as the number of C atoms in the alkyl side chain increased. Substitution of a Me group into the 2 or 5 position of the benzoxazole nucleus produced a 2- to 3-fold increase in inhibitory potential for each instance. Eleven of the benzoxazoles enhanced aniline p-hydroxylase activity in rat liver microsomes, whereas one, zoxazolamine, was inhibitory; no relation was apparent between physicochem. properties and degree of enhancement of aniline p-hydroxylase activity. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Recommanded Product: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1-(Hydroxymethyl)-1H-benzotriazole: An Efficient Ligand for Copper-Catalyzed Ullmann-Type Coupling Reaction Leading to Expeditious Synthesis of Diverse Benzoxazoles and Benzothiazoles was written by Singh, Mala;Bose, Priyanka;Singh, Anoop S.;Tiwari, Vinod K.. And the article was included in ChemistrySelect in 2019.Electric Literature of C13H8BrNO This article mentions the following:

Cu-Catalyzed Ullmann coupling of aryl bromides and amides/thioamides was performed for the facile synthesis of diverse benzoxazoles and benzothiazoles I [R = H, 2-Me, 4-Br, etc.; R¹ = H, Cl; R² = H, Br; X = O, S] in the presence of 1-(hydroxymethyl)-1H-benzotriazole as ligand and K₂CO₃ as base in anhydrous DMF at 120 °C. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Electric Literature of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Electric Literature of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Study on nonaqueous phase Maillard reaction of glucose/L-lysine model system was written by Yang, Ji;Yang, Liu;Gao, Tao;Wu, Yi-qin;Cao, Qiu-e. And the article was included in Yancao Keji in 2011.Category: benzoxazole This article mentions the following:

The thermogravimetric characteristics of glucose, L-lysine and their mixture were determined by thermogravimetry. The pyrolytic products of glucose and L-lysine mixture at 5 temperature ranges were analyzed by the combination of thermogravimetry, solid phase microextraction and gas chromatog.-mass spectrometry (TG-SPME-GC-MS). The effects of the proportion of glucose to L-lysine, and air flow on the yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine were investigated as well. The results showed that : (1) the activation energy of reaction of glucose/L-lysine model system was far lower than that of degradation on their own. There was an endothermic process at the early reaction stage. In the temperature range of 135 to 245°C weight loss started, the mixture lost about 40% of its weight (2) 39 Compounds were identified in pyrolytic products of the model system. Ketones and furfurals were the main products at 100 to 250°C. From 250 to 350°C, pyrazine, pyridine, pyrrole, oxazole, imidazole and other nitrogenous heterocyclic compounds were detected. And the important flavor compounds were produced started from 150°C. (3) The yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine culminated at air velocity of 200 mL/min and the mass ratio of glucose to L-lysine of 1:1. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Category: benzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Transfer of the substituent effect in series of cis- and transcinnamic acids was written by Zdanovich, V. I.;Parnes, Z. N.;Kursanov, D. N.. And the article was included in Doklady Akademii Nauk SSSR in 1965.Related Products of 5676-58-4 This article mentions the following:

Potentiometric determination of dissociation constants was performed for the cis- and trans-cinnamic acids and their benzoic acid analogs in 49% EtOH at 25°. The following K × 10⁶ were found for: benzoic acids, trans-cinnamic acid and cis-cinnamic acids, resp. with indicated substituents: H 1.25; 1.05 (m. 135.2-5.7°); 2.79 (m. 67-8°); p-O₂N 12.0; –; –; m-O₂N 13.7; 3.82 (m. 205-6°); 6.40 (m. 159-9.5°); p-Cl 2.38; 2.00 (m. 249.5-9.8°); 4.09 (m. 112.8-14°); p-Br 3.65; 1.92 (m. 264.7-5.5°); 4.02 (m. 127.6-8.5°); p-MeO 0.68; 0.70 (m. 188-8.2°); 1.78 (m. 68.8-9.7°); p-H₂N 0.17; –; –; p-Me₂N –; 0.32 (m. 118-20°); –. The following Hammett reaction constants were determined: ester hydrolysis trans isomer 0.540; cis isomers 0.461; dissociation of the acids trans isomers 0.539; cis isomers 0.422. Transfer of the substituent effects is more effective in trans-cinnamic acids than in the cis isomers. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Related Products of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Related Products of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

New Approach for Controllable Synthesis of N-MnO_x Micro-flowers and Their Superior Catalytic Performance for Benzoxazole Synthesis was written by Tang, Jun;Cao, Yali;Ruan, Fei;Li, Fengfeng;Jin, Yangxin;Ha, Minh Ngoc;Han, Xinya;Ke, Qingping. And the article was included in Industrial & Engineering Chemistry Research in 2020.Related Products of 99586-31-9 This article mentions the following:

Herein, the novel approach for controlled synthesis of nitrogen doped MnO_x (denoted as N-MnO₂, N-Mn₅O₈ and N-Mn₃O₄) by adjusting the heteroatom nitrogen amount is reported. It was shown that N-MnO₂ catalyst is a sustainable and cost-effective heterogeneous catalyst for condensation of 2-aminophenols and o-phenylenediamine with alcs. to afford the corresponding benzoxazoles and benzimidazole, resp. The N-MnO₂ catalyst displayed >99.9% yield for benzoxazole synthesis under room temperature and no decay (10 cycles), compared with the negligible activity (∼0%) for MnO₂ catalysts. X-ray absorption spectroscopies and exptl. studies uncovered that oxygen vacancies, generated by heteroatom N doping, act as the key role for promoting intramol. oxidative dehydrogenation of alc. and 2-aminophenol derivatives to directly yield desired products. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Related Products of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Related Products of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Hypervalent iodine-mediated synthesis of benzoxazoles and benzimidazoles via an oxidative rearrangement was written by Zhang, Xiaohui;Huang, Ruofeng;Marrot, Jerome;Coeffard, Vincent;Xiong, Yan. And the article was included in Tetrahedron in 2015.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

A Beckmann-type rearrangement of o-hydroxy and o-aminoaryl N-H ketimines was developed to prepare benzoxazoles and N-Ts benzimidazoles, resp. The ketimine derivatives were easily prepared by condensation of ammonia with the corresponding ketones and (diacetoxyiodo)benzene acts as an efficient oxidant to trigger the [1,2]-aryl migration towards the formation of the desired heterocycles. Depending on the substitution pattern, the results revealed another mechanistic pathway through which benzisoxazoles or 1H-indazoles could be formed. The Beckmann-type rearrangement strategy was applied to the synthesis of benzimidazole-containing biorelevant targets such as chlormidazole and clemizole. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Name: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Copper-catalyzed an efficient synthesis, characterization of 2-substituted benzoxazoles, 2-substituted benzothiazoles derivatives and their anti-fungal activity was written by Sirgamalla, Rambabu;Kommakula, Ashok;Konduru, Sumalatha;Ponakanti, Ravindar;Devaram, J.;Boda, Sakram. And the article was included in Chemical Data Collections in 2020.Formula: C13H8BrNO This article mentions the following:

An efficient synthesis of 2-substituted benzoxazoles, (I) (R = H, Me, Cl, NO₂; R1 = 3-F, 2-OH, 4-Me, 4-OMe, etc.) and 2-substituted benzothiazole (I) (R = H, Me, Cl, NO₂; R1 = 4-F, 4-Me, 4-OMe, 4-NO₂, etc.) from condensation of 2-aminophenol, and 2-aminothiophenol react with various aldehydes in Cu₂O in the presence of DMSO oxidant system has been developed. This reaction is operationally simple, proceeds with copper catalysts, tolerates a wide range of functionalities, and provides elemental anal. (C, H, N) providing desired products in good to excellent yields. All the synthesized compounds were screened for anti-fungal activity. Among all the compounds shows good activity I (R = H, R₁= 4-OMe; R = Me, R₁= 4-OMe; R = Cl, R₁= 4-OMe; R = Cl, R₁= 4-OH), (III) and (II) (R = H, R₁= 4-F; R = H, R₁= 4-OMe) shows equal to reference drug. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Formula: C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Gold(I) complexes of azoles was written by Matovic, Zoran D.;Radanovic, Dusan J.;Ponticelli, G.;Scano, P.;Efimenko, I. A.. And the article was included in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994.COA of Formula: C9H9NO This article mentions the following:

(Di-Me sulfide)AuCl reacts with azoles to give adducts [LAuX]₂ [L = N-methylimidazole (N-MeIm), N-ethylimidazole (N-EtIm), N-propylimidazole (N-PrIm), 2-methylbenzoxazole (2-MeBO) and 2,5-dimethylbanzoxazole (2,5-diMeBO); X = Cl or Br] which were characterized analy. and spectroscopically, including ¹H-n.m.r.I.r. and Raman studies showed that the compounds were binuclear with bridging halogen atoms. A nitrogen-containing ligand was coordinated to nitrogen N(3) atom of the azole ring in monodentate fashion. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem