Month: February 2023

Zheng, Jun et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2019 | CAS: 132227-03-3

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Recommanded Product: 132227-03-3

Palladium-catalyzed trisallylation of benzoxazoles and 2-aryl-1,3,4-oxadiazoles with alkyne was written by Zheng, Jun;Hosseini-Eshbala, Fereshteh;Dong, Ya-Xi;Breit, Bernhard. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Recommanded Product: 132227-03-3 This article mentions the following:

A Pd-catalyzed direct C-H trisallylation of azoles with alkyne has been described. A consecutive C(sp2)-H allylation/olefin isomerization/double C(sp3)-H allylation of azoles and alkyne via a palladium catalysis system proceeds efficiently to afford the corresponding C2-alkenylated azoles containing an all quaternary carbon center. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Recommanded Product: 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Recommanded Product: 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Vijaykumar, Gonela et al. published their research in Organometallics in 2017 | CAS: 132227-03-3

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Category: benzoxazole

Abnormal-NHC-Supported Nickel Catalysts for Hydroheteroarylation of Vinylarenes was written by Vijaykumar, Gonela;Jose, Anex;Vardhanapu, Pavan K.;P, Sreejyothi;Mandal, Swadhin K.. And the article was included in Organometallics in 2017.Category: benzoxazole This article mentions the following:

Herein the authors report the hydroheteroarylation of vinylarenes with benzoxazole in the presence of a free abnormal N-heterocyclic carbene and Ni(COD)2, resulting in 1,1-diarylethane products exclusively. In an attempt to understand the mechanism of this catalytic reaction, two abnormal-NHC (aNHC)-coordinated Ni(II) cyclooctenyl complexes were isolated and their solid-state structures were determined by x-ray crystallog. studies. These Ni(II) cyclooctenyl complexes act as active catalyst precursors to generate in situ aNHC-Ni(0) species, which undergo oxidative addition with heteroarene to form Ni(II) hydride intermediates. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Category: benzoxazole).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Yang, Jin et al. published their research in Tetrahedron in 2019 | CAS: 132227-03-3

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Computed Properties of C8H7NO2

Mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes as precatalysts for direct arylation of azoles with aryl bromides was written by Yang, Jin. And the article was included in Tetrahedron in 2019.Computed Properties of C8H7NO2 This article mentions the following:

A series of mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes with general formula [(NHC)Pd(η3-allyl)]2(μ2-N-heterocycles)(BF4)2 were prepared in one pot based on anion metathesis of (NHC)Pd(η3-allyl)Cl complexes and then ligand replacement with N-heterocycles [N-heterocycles = pyrazine (pyz), 4,4′-bipyridine (bpy) and trans-4,4′-bipyridylethylene (bpe)]. The solid-state structures showed dinuclear structures with two palladium(II) centers holding together by bridged N-heterocycles. Initially investigation of the obtained complexes as precatalysts for direct C-H bond arylation of azoles with aryl bromides was carried out. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Computed Properties of C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Computed Properties of C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Wang, Jian et al. published their research in Chemistry Letters in 2022 | CAS: 132227-03-3

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.HPLC of Formula: 132227-03-3

TEMPO/PhI(OAc)2-mediated Direct Sulfoximination of Benzoxazoles under Metal-free Conditions was written by Wang, Jian;Tu, Changqing;Feng, Mei-Lin;Li, Nan. And the article was included in Chemistry Letters in 2022.HPLC of Formula: 132227-03-3 This article mentions the following:

A metal-free reaction system consisting of TEMPO and PhI(OAc)2 for the oxidative C-N coupling of benzoxazoles with NH-sulfoximines had been developed to obtain arylsulfoximines I [R1 = H, 5-Cl, 7-Br, etc.; R2 = Me, Et, n-Bu, Bn; R3 = Ph, 4-FC6H4, 2-BrC6H4, etc.]. The reaction could proceed under ambient atm. without any metal catalyst at room temperature to afford the corresponding 2-iminoazoles in moderate to high yields. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3HPLC of Formula: 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.HPLC of Formula: 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chen, Wei et al. published their research in Journal of Coordination Chemistry in 2018 | CAS: 132227-03-3

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Electric Literature of C8H7NO2

Heteroleptic palladium(II) complexes containing N-heterocyclic carbenes and 4-phenyl-1H-1,2,3-triazole: Synthesis, characterization, and catalytic application was written by Chen, Wei;Yang, Jin. And the article was included in Journal of Coordination Chemistry in 2018.Electric Literature of C8H7NO2 This article mentions the following:

Reaction of the dimeric N-heterocyclic carbene (NHC) palladium compounds [Pd(μ-Cl)(Cl)(NHC)]2 with 4-phenyl-1H-1,2,3-triazole gave four mono- and dinuclear complexes 1–4. Mononuclear complexes 1 and 2 [(NHC)PdCl2(4-phenyl-1H-1,2,3-triazole)] were obtained when the reactions were performed in CH2Cl2, whereas dinuclear complexes 3 and 4 [Pd2(μ-Cl)(μ-4-phenyl-1H-1,2,3-triazole)Cl2(NHC)2] were obtained when the reactions were performed in THF in reflux with Et3N as the base. Further explorations of the catalytic properties of for Pd-catalyzed transformations were performed and these complexes exhibited moderate to high catalytic activities for Suzuki-Miyaura coupling and arylation of benzoxazoles with aryl bromides. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Electric Literature of C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Electric Literature of C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Guo, Qiang et al. published their research in Henan Shifan Daxue Xuebao, Ziran Kexueban in 2013 | CAS: 99586-31-9

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Reference of 99586-31-9

Microwave irradiation promoted synthesis of 2-substituted benzoxazole compound was written by Guo, Qiang;Yang, Yafen;Cheng, Biao;Zhang, Fengtao;Fan, Xuesen. And the article was included in Henan Shifan Daxue Xuebao, Ziran Kexueban in 2013.Reference of 99586-31-9 This article mentions the following:

A clean and efficient synthesis of 2-substituted benzoxazole compound through tandem reactions of 2-aminophenol and aldehydes mediated with [bmim][BF4] under MWI has been developed. Compared with literature methods toward 2-substituted benzoxazole compound, the synthetic strategy presented in the paper has such advantages as enhanced reaction rate, high yield and environmental protection. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Reference of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Reference of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Connelly, Stephen et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 99586-31-9

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole

Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors was written by Connelly, Stephen;Mortenson, David E.;Choi, Sungwook;Wilson, Ian A.;Powers, Evan T.;Kelly, Jeffery W.;Johnson, Steven M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

Rate-limiting dissociation of the tetrameric protein transthyretin (TTR), followed by monomer misfolding and misassembly, appears to cause degenerative diseases in humans known as the transthyretin amyloidoses, based on human genetic, biochem. and pharmacol. evidence. Small mols. that bind to the generally unoccupied thyroxine binding pockets in the native TTR tetramer kinetically stabilize the tetramer, slowing subunit dissociation proportional to the extent that the mols. stabilize the native state over the dissociative transition state-thereby inhibiting amyloidogenesis. Herein, the authors use previously reported structure-activity relationship data to develop two semi-quant. algorithms for identifying the structures of potent and selective transthyretin kinetic stabilizers/amyloidogenesis inhibitors. The viability of these prediction algorithms, in particular the more robust in silico docking model, is perhaps best validated by the clin. success of tafamidis, the first-in-class drug approved in Europe, Japan, South America, and elsewhere for treating transthyretin aggregation-associated familial amyloid polyneuropathy. Tafamidis is also being evaluated in a fully-enrolled placebo-controlled clin. trial for its efficacy against TTR cardiomyopathy. These prediction algorithms will be useful for identifying second generation TTR kinetic stabilizers, should these be needed to ameliorate the central nervous system or ophthalmol. pathol. caused by TTR aggregation in organs not accessed by oral tafamidis administration. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Quality Control of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Bhagat, Saket B. et al. published their research in Journal of Chemical Sciences (Berlin, Germany) in 2018 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Electric Literature of C9H9NO

Sodium dichloroiodate promoted C-C bond cleavage: An efficient synthesis of 1,3-benzazoles via condensation of o-amino/mercapto/hydroxyanilines with β-diketones was written by Bhagat, Saket B.;Ghodse, Shrikant M.;Telvekar, Vikas N.. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2018.Electric Literature of C9H9NO This article mentions the following:

An efficient aqueous sodium dichloroiodate (NaICl2) mediated protocol is developed for the synthesis of benzo-fused azoles I (R1 = H, Me, Cl; R2 = Me, Et, i-Pr, Ph; X = NH, O, S) by the cyclization of 2-amino-substituted anilines, thiophenols or phenols 2-HX-5-R1C6H3NH2 with β-diketone compounds R2C(O)CH2C(O)R3 (R3 = Me, Et, i-Pr, Ph). The reactions gave moderate to good yield of the corresponding 2-substituted benzimidazoles, benzothiazoles or benzoxazoles, resp., under mild conditions. This tandem process involved a C-C bond cleavage and C-N bond formation. The reaction provides a rapid access to 1,3-benzazoles I in good yields, thus speeding up the drug discovery process. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Electric Literature of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Gu, Lijun et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2013 | CAS: 99586-31-9

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Name: 2-(3-Bromophenyl)benzo[d]oxazole

A novel strategy for the construction of substituted benzoxazoles via a tandem oxidative process was written by Gu, Lijun;Jin, Cheng;Guo, Junming;Zhang, Lizhu;Wang, Wei. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2013.Name: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A practical and simple synthesis of benzoxazoles from easily available substrates was developed. The protocol is triggered by an iron-catalyzed tandem oxidative process from simple toluene derivatives and 2-aminophenols. This method represents a straightforward approach to access substituted benzoxazoles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Name: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

George, Smitha et al. published their research in Applied Organometallic Chemistry in 2021 | CAS: 99586-31-9

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Heterogeneous palladium (II)-complexed dendronized polymer: A rare palladium catalyst for the one-pot synthesis of 2-arylbenzoxazoles was written by George, Smitha;Sreekumar, Krishnapillai. And the article was included in Applied Organometallic Chemistry in 2021.Name: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

The palladium complex of dendronized amine polymer (EG-Gn-Pd, n = 0, 1 and 2) having ethylene glycol-initiated polyepichlorohydrin as core was synthesized on a Merrifield resin support and was well characterized. Generally, palladium catalysts are known for carbon-carbon coupling reactions. Here, a developed catalyst was found to be good for benzoxazole synthesis. Higher generation dendronized polymer (EG-G2-Pd) was found to be better catalyst over lower generation dendronized polymers. Moreover, dendronized polymers were found to be a better catalyst over dendrigraft polymers. The catalyst reusability was checked and good yield was obtained for five cycles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Name: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem