New discoveries in chemical research and development in 2021. As an important bridge between the micro, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Oshimoto, Kohei, once mentioned the application of 108-32-7, Safety of 4-Methyl-1,3-dioxolan-2-one, category is benzoxazole. Now introduce a scientific discovery about this category.
We describe herein the synthetic method to benzoxazole derivatives via the copper-catalyzed hydroamination of alkynones with 2-aminophenols. The method produced a wide variety of functionalized benzoxazole derivatives in good yields. Preliminary mechanistic experiments revealed that the reaction would proceed through the copper-catalyzed hydroamination of alkynones and the sequential intramolecular cyclization of beta-iminoketones/elimination of acetophenone promoted by the copper catalyst.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem