New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. In an article, author is Kaur, Avneet, once mentioned the application of 348-54-9, Category: benzoxazole, Name is 2-Fluoroaniline, molecular formula is C6H6FN, molecular weight is 111.1169, category is benzoxazole. Now introduce a scientific discovery about this category.
A series of N-(2-(3,4,5-trimethoxybenzy1)-benzoxazole-5-yObenzamide derivatives (3a-3n) was synthesized and evaluated for its in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50 < 1 mu M), were evaluated in vivo for their anti-inflammatory and ulcerogenic potential. Out of the fourteen newly synthesized compounds; 3b, 3d, 3e, 3h, 31 and 3m were found to be most potent COX-2 inhibitors in in vitro enzymatic assay with IC 50 in the range of 0.14-0.69 mu M. In vivo anti-inflammatory activity of these six compounds (3b, 3d, 3e, 3h, 31 and 3m) was assessed by carrageenan induced rat paw edema method. The compound 3b (79.54%), 31 (75.00%), 3m (72.72%) and 3d (68.18%) exhibited significant anti-inflammatory activity than standard drug ibuprofen (65.90%). Ulcerogenic activity with histopathological studies was performed, and the screened compounds demonstrated significant gastric tolerance than ibuprofen. Molecular Docking study was also performed with resolved crystal structure of COX-2 to understand the interacting mechanisms of newly synthesized inhibitors with the active site of COX-2 enzyme and the results were found to be in line with the biological evaluation studies of the compounds. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 348-54-9 is helpful to your research. Category: benzoxazole.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem