New research progress on 367-11-3 in 2021.Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 367-11-3, Name is 1,2-Difluorobenzene, molecular formula is , belongs to benzoxazole compound. In a document, author is Li, Zhengyu, SDS of cas: 367-11-3.
A one-pot strategy for the diversified synthesis of 3-difluoromethyl benzoxazole-2-thiones is reported. The reaction of 2-aminophenol, sodium chlorodifluoroacetate, and elemental sulfur in the presence of NaOt-Bu gives exclusively 3-difluoromethyl benzoxazole-2-thiones in good yield (up to 98%). The mechanism of this reaction presumably involves first cyclization of 2-aminophenols with thiocarbonyl fluoride, followed by N-difluoromethylation with difluorocarbene. The developed synthetic procedures are versatile, robust, and easily scalable for the synthesis of 3-difluoromethyl benzoxazole-2-thione derivatives, some of which have shown insecticidal activities.
If you are hungry for even more, make sure to check my other article about 367-11-3, SDS of cas: 367-11-3.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem