8-Sep-2021 News Awesome and Easy Science Experiments about C2BF2LiO4

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 409071-16-5. Application In Synthesis of Lithium difluoro(oxalato)borate.

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals. In an article, author is Labib, Madlen B., once mentioned the application of 409071-16-5, Application In Synthesis of Lithium difluoro(oxalato)borate, Name is Lithium difluoro(oxalato)borate, molecular formula is C2BF2LiO4, molecular weight is 143.7678, MDL number is MFCD27952543, category is benzoxazole. Now introduce a scientific discovery about this category.

In this research, three series of azole-hydrazone derivatives namely, benzimidazole, benzoxazole and benzothiazole were designed and synthesized. Their structures were confirmed by elemental analysis and spectroscopic techniques. Stereochemical configuration of the synthesized compounds (Z/E) was determined. The new derivatives were tested in vitro against both human breast adenocarcinoma (MCF-7) and human hepatic adenocarcinoma (HepG2) cell lines. The most active compounds 3h (IC50 = 0.067 mu M against MCF-7) and 3l (IC50 = 0.027 mu M against HepG2) were further tested for Epidermal Growth Factor Receptor (EGFR) inhibitory activity. The most active 3h on EGFR was then screened for HER2 and VEGFR enzymes. Caspase-3/9 protein level expression were measured for the two compounds 3h and 3l. Cell cycle analysis showed pre G1 apoptosis and cell cycle arrest at G2/M phase. Up-regulation of Bax and down-regulation of Bcl-2 protein expression level confirmed apoptosis. Molecular docking analysis was performed for all the synthesized compounds inside the active site of EGFR. (C) 2017 Elsevier Inc. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 409071-16-5. Application In Synthesis of Lithium difluoro(oxalato)borate.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem