Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. Reference of 637031-93-7, Name is 3,3-difluorocyclobutanamine hydrochloride, molecular formula is C4H8ClF2N, molecular weight is 143.56, category is benzoxazole. Now introduce a scientific discovery about this category.
Following on from ezutromid, the first-in-class benzoxazole utrophin modulator that progressed to Phase 2 clinical trials for the treatment of Duchenne muscular dystrophy, a new chemotype was designed to optimise its physicochemical and ADME profile. Herein we report the synthesis of SMT022357, a second generation utrophin modulator preclinical candidate, and an asymmetric synthesis of its constituent enantiomers. The pharmacological properties of both enantiomers were evaluated in vitro and in vivo. No significant difference in the activity or efficacy was observed between the two enantiomers; activity was found to be comparable to the racemic mixture. (C) 2019 The Authors. Published by Elsevier Ltd.
Reference of 637031-93-7, If you are interested in benzoxazole, please see other blog about C4H8ClF2N.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem