Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Quality Control of Benzo[d]oxazol-2-amine. Introducing a new discovery about 4570-41-6, Name is Benzo[d]oxazol-2-amine
1,2,4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38alpha MAP kinase inhibition, anti-inflammatory activity and molecular docking studies
Novel N-(benzothiazol/oxazol-2-yl)-2-[(5-(phenoxymethyl)-4-aryl-4H-1,2,4-triazol-3-yl)thio] acetamide derivatives (5a-n) were synthesized and investigated for in vitro anti-inflammatory activity and p38alpha MAP kinase inhibition. Compounds showing good in vitro activities (5a, 5b, 5d, 5e, 5i, 5k and 5l) were studied for their in vivo anti-inflammatory activity using carrageenan induced rat paw edema model. Compound 5b emerged as the most active compound with an edema inhibition of 84.43%. It also showed improved GI safety profile with lower ulcer severity index and lipid peroxidation potential. Also, p38alpha MAP kinase assay of 5b showed superior inhibitory potency (IC50:0.031 ¡À 0.14 muM) than the standard SB 203580 (IC50:0.043 ¡À 0.14 muM). To predict their binding mode compounds were also docked against p38alpha MAP kinase enzyme. Compound 5b and SB 203580 showed hinge region interaction with MET 109.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of Benzo[d]oxazol-2-amine, you can also check out more blogs about4570-41-6
Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem