Chemistry is traditionally divided into organic and inorganic chemistry. SDS of cas: 3621-81-6, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 3621-81-6
Practical synthesis of an enantiomerically pure trans-4,5-disubstituted 2-pyrrolidinone via enzymatic resolution. Preparation of the LTB4 inhibitor BIRZ-227
A practical synthesis of the enantiomerically pure BIRZ-227 (1), a LTB4 inhibitor, has been developed. The key steps include the effective synthesis of the trans-diarylpyrrolidinone (¡À)-8 and the enzymatic resolution of N- acetoxymethyl pyrrolidinone (¡À)-10 by immobilized Lipase Novozym 435. Reduction of pyrrolidinone (+)-8 with borane and subsequent coupling with chlorobenzoxazole 2 furnished BIRZ-227 in high enantiomeric purity (99% ee). The overall process described herein required no chromatographic separation and is amenable to the preparation of multikilogram quantities of the desired drug candidate in a cost-effective manner.
If you are interested in 3621-81-6, you can contact me at any time and look forward to more communication. SDS of cas: 3621-81-6
Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem