Related Products of 3621-81-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 3621-81-6, Name is 2,5-Dichlorobenzooxazole,introducing its new discovery.
Novel benzoxazole inhibitors of mPGES-1
A novel series of potent benzoxazole mPGES-1 inhibitors has been derived from a hit from a high throughput screen. Compound 37 displays mPGES-1 inhibition in an enzyme assay (0.018 muM) and PGE-2 inhibition in a cell-based assay (0.034 muM). It demonstrates 500- and 2500-fold selectivity for mPGES-1 over COX-2 and 6-keto PGF-1alpha, respectively. In vivo PK studies in dogs demonstrate 55% oral bioavailability and an 7 h half-life.
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem