One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of Benzo[d]oxazol-2-amine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4570-41-6, Name is Benzo[d]oxazol-2-amine, molecular formula is C7H6N2O
2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1delta/epsilon
In this study we identified two heterocyclic compounds (5 and 6) as potent and specific inhibitors of CK1delta (IC50 = 0.040 and 0.042 muM, respectively). Whereas compound 5 exhibited fivefold higher affinity towards CK1delta than to CK1epsilon (IC50 CK1epsilon = 0.199 muM), compound 6 also inhibited CK1epsilon (IC50 = 0.0326 muM) in the same range as CK1delta. Selected compound 5 was screened over 442 kinases identifying 5 as Ahighly potent and selective inhibitor of CK1delta. X-ray analysis of 5 bound to CK1delta demonstrated its binding mode. In addition, characterization of 5 and 6 in Acell biological approach revealed the ability of both compounds to inhibit proliferation of tumor cell lines in Adose and cell line specific manner. In summary, our optimizations lead to the development of new highly selective CK1delta and epsilon specific inhibitors with biological activity.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of Benzo[d]oxazol-2-amine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4570-41-6, in my other articles.
Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem