2382-96-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Benzo[d]oxazole-2-thiol, cas is 2382-96-9,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.
Example 1: Preparation of a benzoxazole sulfonamide compound A benzoxazole sulfonamide represented by compound c-6 in the below provided Scheme C, can be prepared as follows. The intermediate c-2 was prepared by adding 2-MERCAPTOBENZOXAZOLE (C-1 which is equal to compound of formula (1) above) (1200 g; 7.94 mol) to 8500 ml ethylacetate in a 20 L flask. Then 1420 g (10.29 mol) potassium carbonate was added at rt. iodomethane (1243 g; 8.76 mol) was added dropwise to this reaction mixture maintaining the internal temperature below 40C. This mixture was stirred for 24 hours while the internal temperature decreased to 20C. The reaction mixture was then treated with 4000 ml water and 138 G NH40H at rt for about 20 minutes. The organic layer was separated and filtered. The aqueous phase was extracted with 1200 ml ethylacetate. The organic layers were collected and washed with 1500 ml water. The organic phase was evaporated under reduced pressure until a final volume of about 2000ML. Magnesium sulphate was added and the mixture was filtered. The filtrate was evaporated under reduced pressure yielding 1288 g of the intermediate c-2 (98 % yield /HPLC purity 99.6 %).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Benzo[d]oxazole-2-thiol, 2382-96-9
Reference£º
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/30739; (2005); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem