The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 392-56-3, Name is Hexafluorobenzene, SMILES is FC1=C(F)C(F)=C(F)C(F)=C1F, in an article , author is Srivastava, Pavan, once mentioned of 392-56-3, COA of Formula: C6F6.
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory
Based on the Gaussian-based quantitative structure-activity relationship (QSAR) and virtual screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEls) having antioxidant potential were designed synthesized, characterized, and evaluated for their ability to enhance learning and memory. The synthesized phenyl benzoxazole derivatives exhibited significant antioxidant potential and AChE inhibitory activity, whereas the antioxidant potential of compound 34 (49.6%) was observed significantly better than standard donepezil (<10%) and parallel to ascorbic acid (56.6%). Enzyme kinetics study of most potent compound 34 (AChE IC50 = 0.363 +/- 0.017 mu M; Ki = 0.19 +/- 0.03 mu M) revealed the true nature and competitive type of inhibition on AChE. The compound 34 was further assessed for in vivo and ex vivo studies and the results showed the significant reversal of cognitive deficits and antioxidant potential at the dose of 5 mg/kg comparable to standard drug donepezil. (C) 2018 Elsevier Masson SAS. All rights reserved. Interested yet? Read on for other articles about 392-56-3, you can contact me at any time and look forward to more communication. COA of Formula: C6F6.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem