Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5535-48-8, Name is (Vinylsulfonyl)benzene, molecular formula is C8H8O2S. In an article, author is Kim, Taejung,once mentioned of 5535-48-8, SDS of cas: 5535-48-8.
Synthesis, Structure Revision, and Cytotoxicity of Nocarbenzoxazole G
The total synthesis of nocarbenzoxazoles F (1) and G (2), originally obtained from the marine-derived halophilic bacterial strain Nocardiopsis lucentensis DSM 44048, was achieved via a simple and versatile route involving microwave-assisted construction of a benzoxazole skeleton, followed by carbon-carbon bond formation with the corresponding aryl bromides. Unfortunately, the H-1 and C-13 NMR spectra of natural nocarbenzoxazole G did not agree with those of the synthesized compound. In particular, the spectra of the isolated and synthesized compounds showed considerable differences in the signals from the protons and carbons in the aryl group. The revised structure was validated by the total synthesis of the actual nocarbenzoxazole G (8c) molecule, which is a regioisomer of the compound that was reported earlier as nocarbenzoxazole G. The synthesized derivatives showed specific cytotoxicity to the human cervical carcinoma cell line, HeLa, but did not have any remarkable effect on the other cell lines.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem