Chemistry, like all the natural sciences, Formula: C6H8O2, begins with the direct observation of nature¡ª in this case, of matter.504-02-9, Name is Cyclohexane-1,3-dione, SMILES is O=C1CC(CCC1)=O, belongs to benzoxazole compound. In a document, author is Ghani, Usman, introduce the new discover.
Carbazoles and Hydrazone-Bridged Thiazole-Pyrrole Derivatives as New Inhibitors of alpha-Glucosidase
Carbazoles and hydrazone-bridged thiazole-pyrrole derivatives are known to exhibit a wide range of biological activities including antimicrobial activity. This work is a further extension of their biological activities that identifies a total of 13 of these derivatives as new alpha-glucosidase inhibitors. The carbazole derivatives exhibited noncompetitive inhibition of the enzyme with the inhibitor possessing the 2-benzoimidazole substitution being the most potent in the series. Compounds possessing the 2-benzothiazole, 2-benzoxazole and quinoline groups were also found to be promising for enzyme inhibition. The hydrazone-bridged thiazole-pyrrole derivatives showed competitive enzyme inhibition with a number of groups responsible for potent enzyme inhibition including 4-nitrophenyl, 4-bromophenyl, and 4-methoxyphenyl groups. Moreover, the hydrazone derivatives with unsubstituted pyrrole ring were found to be more favorable to alpha-glucosidase inhibition than the ones possessing the methyl-substituted ring. The current work may provide new structural and functional diversity to drug discovery of promising alpha-glucosidase inhibitors as anti-diabetic drugs.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 504-02-9. Formula: C6H8O2.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem