Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Felouat, Abdellah, once mentioned the application of 6825-20-3, Name is 3,6-Dibromo-9H-carbazole, molecular formula is C12H7Br2N, molecular weight is 325, MDL number is MFCD00004961, category is benzoxazole. Now introduce a scientific discovery about this category, Recommanded Product: 6825-20-3.
Oligo(ethylene glycol) (OEG) functionalized 2-(2 ‘-Hydroxy benzofuranyl) benzoxazole (HBBO) derivatives: Synthesis, photophysical properties and biomolecules binding studies
Two molecular fluorophores based on a 2-(2’-Hydroxybenzofuranyl) benzoxazole (HBBO) scaffold and presenting an Excited-State Intramolecular Proton Transfer (ESIPT) process are reported herein. These dyes incorporate strongly electrodonating aromatic amino groups on the benzofuranyl side, enabling the appearance of a dual fluorescence emission corresponding to the radiative decay of the excited enol (E*) and keto (K*) tautomers at high and low energy respectively. It was previously demonstrated that dual E*/K* emission could originate from a beneficial decrease of phenolic acidity upon absorption of light leading to a thermodynamic stabilization of the first excited-state. The innovation within these dyes lies in the double functionalization of the aniline moiety with 2-(2-methoxyethoxy)ethyl units which allowed a better solubilization in protic solvents, as compared to their butyl analogs while keeping strong electrodonating capacity. Their intrinsic amphiphilic character leads to a good vectorization in a wide range of solvents from toluene to PBS buffer. The investigation of the photophysical properties of these dyes in solution showed a clear dual emission in apolar solvents with the E* band gradually red-shifting along with the dipole moment of the solvent. Dual emission is also observed in the solid-state when these dyes are doped as 1% wt in PMMA or PS films. Finally, the interactions of one dye with calf-thymus (ct)-DNA and Bovine Serum Albumin (BSA) have been explored and reveal pronounced modifications of the UV-Vis profile of the dye. Additionally, a gradual hypsofluorochromic shift and narrowing of the K* band along with the appearance of the E* fluorescence band upon addition of ct-DNA or BSA is also observed, presumably evidencing an intercalation mode of binding.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem