Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 5535-48-8, Name is (Vinylsulfonyl)benzene, SMILES is O=S(C1=CC=CC=C1)(C=C)=O, belongs to benzoxazole compound. In a document, author is Angajala, Gangadhara, introduce the new discover, COA of Formula: C8H8O2S.
Microwave assisted amberlite-IRA-402 (OH) ion exchange resin catalyzed synthesis of new benzoxazole scaffolds derived from antiinflammatory drugs aceclofenac and mefenamic acid as potential therapeutic agents for inflammation
An efficient microwave assisted synthesis of 2-substituted benzoxazole derivatives from antiinflammatory drugs aceclofenac and mefenamic acid using amberlite-IRA-402 (OH) ion exchange resin as a base catalyst were reported. The synthesized compounds were purified and characterized by H-1 NMR, C-13 NMR and Mass spectroscopy. In silico molecular docking studies were carried out to predict the binding affinity of the synthesized benzoxazole derivatives with COX-2 protein. Molecular Docking analysis showed that compounds 4 and 7 possess excellent binding affinity towards COX-2 with a docking score of -11.6 and -10.4 kcaL/mol respectively. The results obtained from in vitro antiinflammatory studies towards membrane stabilization and proteinase inhibitory activities showed that the synthesized benzoxazole compounds 4 and 7 possess better efficacy when compared to that of standards aceclofenac and etodolac with a percentage inhibition of 74.22 +/- 0.15, 70.64 +/- 0.24 for membrane stabilization and 75.19 +/- 0.12, 71.80 +/- 0.49 for proteinase enzyme assay at 100 mu moL/L. The synthesized compounds 4 and 7 were also evaluated for antioxidant activity which showed good inhibition (70.16 +/- 0.31 and 68.25 +/- 0.49) at 100 mu moL/L which was on Par to that of standard ascorbic acid. (C) 2019 Elsevier B.V. All rights reserved.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5535-48-8 is helpful to your research. COA of Formula: C8H8O2S.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem