Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of 2-(4-Fluorophenyl)acetic acid, 405-50-5, Name is 2-(4-Fluorophenyl)acetic acid, molecular formula is C8H7FO2, belongs to benzoxazole compound. In a document, author is Vodnala, Nagaraju, introduce the new discover.
Facile Protocols towards C2-Arylated Benzoxazoles using Fe(III)-Catalyzed C(sp(2)-H) Functionalization and Metal-Free Domino Approach
Considering their growing attention in the field of medicinal chemistry and drug-discovery research, the facile and convenient approaches towards the preparation of 2-aryl benzoxazole derivatives have been described. The transformation is accomplished by using Fe(III)-catalyzed C-H activation of benzoxazoles with boronic acids to obtain a wide range of C2-arylated benzoxazoles in high yields. The developed method excludes the formation of self-coupling compounds as side products. On the other hand, the synthesis of the products is also achieved via a metal-free domino protocol by the reaction between 1-nitroso-2-naphthol and acetophenones using catalytic amounts of CBr4 in the presence of Cs2CO3 as base. The devised tandem method avoids the use of pre-activated alpha-haloketones as substrates. Due to their immense impact in marketed drugs and molecules under clinical trial, the described method can be a powerful tool for their synthesis which restricts the use of precious metals as catalyst.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 405-50-5. Application In Synthesis of 2-(4-Fluorophenyl)acetic acid.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem